Recent Advances in Cell‐Mediated Drug Delivery Systems for Nanomedicine and Imaging DOI
Li Li, Zhi Qi

Published: Oct. 26, 2021

Therapeutic delivery systems have been developed and used to carry therapeutic agents such as drugs, proteins, genes targeted disease sites enhance drug efficacy reduce toxicity. However, off-target immunogenicity remain the major challenges for systems. To overcome these problems, various cell-mediated platforms explored specifically efficiently deliver into owing their unique properties. This chapter summarizes recent advances in application. The cell types functions delivery, responsive application treatment imaging well clinical applications discussed.

Language: Английский

Erythrocytes as Carriers: From Drug Delivery to Biosensors DOI Creative Commons
L. D. Koleva, Elizaveta Bovt, Фазоил И. Атауллаханов

et al.

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(3), P. 276 - 276

Published: March 18, 2020

Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Such erythrocytes can act as carriers that prolong the drug's action due to its gradual release from carrier; bioreactors with encapsulated enzymes performing necessary reactions, while remaining inaccessible immune system and plasma proteases; or tool for targeted drug target organs, primarily cells of reticuloendothelial system, liver spleen. To date, have been studied wide range drugs, such enzymes, antibiotics, anti-inflammatory, antiviral etc., diagnostic purposes (e.g. magnetic resonance imaging). The review focuses only on drugs loaded inside defines main lines research bioactive substances, well advantages limitations their application. Particular attention paid in vivo studies, opening-up potential clinical use into erythrocytes.

Language: Английский

Citations

92
Synthesis of Metal–Organic Framework Nanosheets with High Relaxation Rate and Singlet Oxygen Yield DOI
Yuewu Zhao, Ye Kuang, Min Liu

et al.

Chemistry of Materials, Journal Year: 2018, Volume and Issue: 30(21), P. 7511 - 7520

Published: Oct. 23, 2018

A novel gadolinium–porphyrin metal–organic framework (MOF) nanosheet was synthesized by coordination chelation between gadolinium(III) ions and 4,4,4,4-(porphine-5,10,15,20-tetrayl) tetrakis (benzoic acid) (TCPP). The mechanism molecular structure of the prepared Gd-TCPP products were analyzed through comparison (benzenesulfonic (TPPS) TCPP. MOF nanosheets exhibit a high relaxation rate 40.8 mM–1 s–1, which is better than rates for most reported contrast agents. In addition, photosensitive activity enhanced compared to TCPP owing special periodic porous MOF, indicating that could produce singlet oxygen (1O2) more effectively under irradiation visible light. Performance enhancement observed both metal organic ligands in nanosheets. This study presents new concept development bifunctional nanomaterials with performance magnetic resonance imaging photodynamic therapy.

Language: Английский

Citations

90
Red Blood Cells for Drug Delivery DOI
Junjie Yan, Jicheng Yu, Chao Wang

et al.

Small Methods, Journal Year: 2017, Volume and Issue: 1(12)

Published: Nov. 14, 2017

Abstract Red blood cells (RBCs), or erythrocytes, have been promising endogenous candidates for drug delivery more than four decades. Armed with a better understanding of the diverse mechanisms and paths delivery, researchers achieved great progress in manufacturing RBC‐based carriers, from both scientific clinical viewpoints. Here, loading methods therapeutics by RBC carriers are surveyed, recent advances design stimuli‐triggered highlighted. Key developing trends challenges, also discussed, an outlook is presented.

Language: Английский

Citations

85
Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances DOI
Endong Zhang,

Philana Phan,

Hanan Ahmed Algarni

et al.

Pharmaceutical Research, Journal Year: 2022, Volume and Issue: 39(11), P. 2673 - 2698

Published: July 7, 2022

Language: Английский

Citations

30
Engineered gadolinium-based nanomaterials as cancer imaging agents DOI
Yujun Zeng, Haonan Li, Zhiqian Li

et al.

Applied Materials Today, Journal Year: 2020, Volume and Issue: 20, P. 100686 - 100686

Published: May 26, 2020

Language: Английский

Citations

44
Recent Progress in Red Blood Cells-Derived Particles as Novel Bioinspired Drug Delivery Systems: Challenges and Strategies for Clinical Translation DOI Creative Commons

Antony Vincy,

Sarmistha Mazumder,

Amrita Amrita

et al.

Frontiers in Chemistry, Journal Year: 2022, Volume and Issue: 10

Published: April 27, 2022

Red Blood Cells (RBCs)-derived particles are an emerging group of novel drug delivery systems. The natural attributes RBCs make them potential candidates for use as a carrier or nanoparticle camouflaging material they innately biocompatible. have been studied multiple decades in applications but their evolution the clinical arena considerably slower. They garnering attention unique capability conserving membrane proteins post fabrication that help to stay non-immunogenic biological environment prolonging circulation time and improving therapeutic efficiency. In this review, we discuss about synthesis, significance, various biomedical above-mentioned classes engineered RBCs. This article is focused on current state translation analysis hindrances associated with transition from lab clinic applications.

Language: Английский

Citations

27
Nanotechnology-based cell-mediated delivery systems for cancer therapy and diagnosis DOI
Vahid Alimardani,

Zahra Rahiminezhad,

Mahvash Dehghankhold

et al.

Drug Delivery and Translational Research, Journal Year: 2022, Volume and Issue: 13(1), P. 189 - 221

Published: Sept. 8, 2022

Language: Английский

Citations

26
Erythrocyte‐Inspired Functional Materials for Biomedical Applications DOI Creative Commons
Zhiqiang Luo, Lingyu Sun, Feika Bian

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 10(6)

Published: Dec. 29, 2022

Abstract Erythrocytes are the most abundant cells in blood. As results of long‐term natural selection, their specific biconcave discoid morphology and cellular composition responsible for gaining excellent biological performance. Inspired by intrinsic features erythrocytes, various artificial biomaterials emerge find broad prospects biomedical applications such as therapeutic delivery, bioimaging, tissue engineering. Here, a comprehensive review from fabrication to erythrocyte‐inspired functional materials is given. After summarizing mimicking functions synthesis strategies particles with morphologies presented. The emphasis on practical these bioinspired materials. perspectives future possibilities advanced also discussed. It hoped that summary existing studies can inspire researchers develop novel biomaterials; thus, accelerating progress toward clinical applications.

Language: Английский

Citations

18
Red blood cells based nanotheranostics: A smart biomimetic approach for fighting against cancer DOI
Ranjita Misra,

Naomi Sanjana Sharath

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 661, P. 124401 - 124401

Published: July 8, 2024

Language: Английский

Citations

2
Recent Advances in Cell‐Mediated Drug Delivery Systems for Nanomedicine and Imaging DOI
Li Li, Zhi Qi

Published: Oct. 26, 2021

Therapeutic delivery systems have been developed and used to carry therapeutic agents such as drugs, proteins, genes targeted disease sites enhance drug efficacy reduce toxicity. However, off-target immunogenicity remain the major challenges for systems. To overcome these problems, various cell-mediated platforms explored specifically efficiently deliver into owing their unique properties. This chapter summarizes recent advances in application. The cell types functions delivery, responsive application treatment imaging well clinical applications discussed.

Language: Английский

Citations

1