Erythrocytes as Carriers: From Drug Delivery to Biosensors
Pharmaceutics,
Год журнала:
2020,
Номер
12(3), С. 276 - 276
Опубликована: Март 18, 2020
Drug
delivery
using
natural
biological
carriers,
especially
erythrocytes,
is
a
rapidly
developing
field.
Such
erythrocytes
can
act
as
carriers
that
prolong
the
drug's
action
due
to
its
gradual
release
from
carrier;
bioreactors
with
encapsulated
enzymes
performing
necessary
reactions,
while
remaining
inaccessible
immune
system
and
plasma
proteases;
or
tool
for
targeted
drug
target
organs,
primarily
cells
of
reticuloendothelial
system,
liver
spleen.
To
date,
have
been
studied
wide
range
drugs,
such
enzymes,
antibiotics,
anti-inflammatory,
antiviral
etc.,
diagnostic
purposes
(e.g.
magnetic
resonance
imaging).
The
review
focuses
only
on
drugs
loaded
inside
defines
main
lines
research
bioactive
substances,
well
advantages
limitations
their
application.
Particular
attention
paid
in
vivo
studies,
opening-up
potential
clinical
use
into
erythrocytes.
Язык: Английский
Synthesis of Metal–Organic Framework Nanosheets with High Relaxation Rate and Singlet Oxygen Yield
Chemistry of Materials,
Год журнала:
2018,
Номер
30(21), С. 7511 - 7520
Опубликована: Окт. 23, 2018
A
novel
gadolinium–porphyrin
metal–organic
framework
(MOF)
nanosheet
was
synthesized
by
coordination
chelation
between
gadolinium(III)
ions
and
4,4,4,4-(porphine-5,10,15,20-tetrayl)
tetrakis
(benzoic
acid)
(TCPP).
The
mechanism
molecular
structure
of
the
prepared
Gd-TCPP
products
were
analyzed
through
comparison
(benzenesulfonic
(TPPS)
TCPP.
MOF
nanosheets
exhibit
a
high
relaxation
rate
40.8
mM–1
s–1,
which
is
better
than
rates
for
most
reported
contrast
agents.
In
addition,
photosensitive
activity
enhanced
compared
to
TCPP
owing
special
periodic
porous
MOF,
indicating
that
could
produce
singlet
oxygen
(1O2)
more
effectively
under
irradiation
visible
light.
Performance
enhancement
observed
both
metal
organic
ligands
in
nanosheets.
This
study
presents
new
concept
development
bifunctional
nanomaterials
with
performance
magnetic
resonance
imaging
photodynamic
therapy.
Язык: Английский
Red Blood Cells for Drug Delivery
Small Methods,
Год журнала:
2017,
Номер
1(12)
Опубликована: Ноя. 14, 2017
Abstract
Red
blood
cells
(RBCs),
or
erythrocytes,
have
been
promising
endogenous
candidates
for
drug
delivery
more
than
four
decades.
Armed
with
a
better
understanding
of
the
diverse
mechanisms
and
paths
delivery,
researchers
achieved
great
progress
in
manufacturing
RBC‐based
carriers,
from
both
scientific
clinical
viewpoints.
Here,
loading
methods
therapeutics
by
RBC
carriers
are
surveyed,
recent
advances
design
stimuli‐triggered
highlighted.
Key
developing
trends
challenges,
also
discussed,
an
outlook
is
presented.
Язык: Английский
Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances
Pharmaceutical Research,
Год журнала:
2022,
Номер
39(11), С. 2673 - 2698
Опубликована: Июль 7, 2022
Язык: Английский
Engineered gadolinium-based nanomaterials as cancer imaging agents
Applied Materials Today,
Год журнала:
2020,
Номер
20, С. 100686 - 100686
Опубликована: Май 26, 2020
Язык: Английский
Recent Progress in Red Blood Cells-Derived Particles as Novel Bioinspired Drug Delivery Systems: Challenges and Strategies for Clinical Translation
Antony Vincy,
Sarmistha Mazumder,
Amrita Amrita
и другие.
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Апрель 27, 2022
Red
Blood
Cells
(RBCs)-derived
particles
are
an
emerging
group
of
novel
drug
delivery
systems.
The
natural
attributes
RBCs
make
them
potential
candidates
for
use
as
a
carrier
or
nanoparticle
camouflaging
material
they
innately
biocompatible.
have
been
studied
multiple
decades
in
applications
but
their
evolution
the
clinical
arena
considerably
slower.
They
garnering
attention
unique
capability
conserving
membrane
proteins
post
fabrication
that
help
to
stay
non-immunogenic
biological
environment
prolonging
circulation
time
and
improving
therapeutic
efficiency.
In
this
review,
we
discuss
about
synthesis,
significance,
various
biomedical
above-mentioned
classes
engineered
RBCs.
This
article
is
focused
on
current
state
translation
analysis
hindrances
associated
with
transition
from
lab
clinic
applications.
Язык: Английский
Nanotechnology-based cell-mediated delivery systems for cancer therapy and diagnosis
Drug Delivery and Translational Research,
Год журнала:
2022,
Номер
13(1), С. 189 - 221
Опубликована: Сен. 8, 2022
Язык: Английский
Erythrocyte‐Inspired Functional Materials for Biomedical Applications
Advanced Science,
Год журнала:
2022,
Номер
10(6)
Опубликована: Дек. 29, 2022
Abstract
Erythrocytes
are
the
most
abundant
cells
in
blood.
As
results
of
long‐term
natural
selection,
their
specific
biconcave
discoid
morphology
and
cellular
composition
responsible
for
gaining
excellent
biological
performance.
Inspired
by
intrinsic
features
erythrocytes,
various
artificial
biomaterials
emerge
find
broad
prospects
biomedical
applications
such
as
therapeutic
delivery,
bioimaging,
tissue
engineering.
Here,
a
comprehensive
review
from
fabrication
to
erythrocyte‐inspired
functional
materials
is
given.
After
summarizing
mimicking
functions
synthesis
strategies
particles
with
morphologies
presented.
The
emphasis
on
practical
these
bioinspired
materials.
perspectives
future
possibilities
advanced
also
discussed.
It
hoped
that
summary
existing
studies
can
inspire
researchers
develop
novel
biomaterials;
thus,
accelerating
progress
toward
clinical
applications.
Язык: Английский
Red blood cells based nanotheranostics: A smart biomimetic approach for fighting against cancer
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
661, С. 124401 - 124401
Опубликована: Июль 8, 2024
Язык: Английский
Recent Advances in Cell‐Mediated Drug Delivery Systems for Nanomedicine and Imaging
Опубликована: Окт. 26, 2021
Therapeutic
delivery
systems
have
been
developed
and
used
to
carry
therapeutic
agents
such
as
drugs,
proteins,
genes
targeted
disease
sites
enhance
drug
efficacy
reduce
toxicity.
However,
off-target
immunogenicity
remain
the
major
challenges
for
systems.
To
overcome
these
problems,
various
cell-mediated
platforms
explored
specifically
efficiently
deliver
into
owing
their
unique
properties.
This
chapter
summarizes
recent
advances
in
application.
The
cell
types
functions
delivery,
responsive
application
treatment
imaging
well
clinical
applications
discussed.
Язык: Английский