Molecularly Imprinted Nanoparticles for Biomedical Applications

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(3)

Published: May 15, 2019

Abstract Molecularly imprinted polymers (MIPs) are synthetic receptors with tailor‐made recognition sites for target molecules. Their high affinity and selectivity, excellent stability, easy preparation, low cost make them promising substitutes to biological in many applications where molecular is important. In particular, spherical MIP nanoparticles (or nanoMIPs) diameters typically below 200 nm have drawn great attention because of their surface‐area‐to‐volume ratio, removal templates, rapid binding kinetics, good dispersion handling ability, undemanding functionalization surface modification, compatibility various nanodevices vivo biomedical applications. Recent years witnessed significant progress made the preparation advanced functional nanoMIPs, which has eventually led expansion from traditional separation catalysis fields burgeoning areas. Here, a comprehensive overview key recent advances nanoMIPs important (including immunoassays, drug delivery, bioimaging, biomimetic nanomedicine) presented. The pros cons each strategy discussed present challenges future perspectives also highlighted.

Language: Английский

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Removal of emerging contaminants from wastewater using advanced treatments. A review

Environmental Chemistry Letters, Journal Year: 2022, Volume and Issue: 20(2), P. 1333 - 1375

Published: Jan. 12, 2022

Language: Английский

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Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 30, 2022

Abstract Chiral discrimination is critical in environmental and life sciences. However, an ideal chiral strategy has not yet been developed because of the inevitable nonspecific binding entity wrong enantiomers or insufficient intrinsic optical activities molecules. Here, we propose “inspector” recognition mechanism (IRM), which implemented on a imprinted polydopamine (PDA) layer coated surface-enhanced Raman scattering (SERS) tag layer. The IRM works based permeability change PDA after scrutiny by inspector molecule. Good enantiomer can specifically recognize fully fill cavities, whereas cannot. Then linear shape aminothiol molecule, as status introduced, only percolate through vacant nonspecifically occupied inducing SERS signal to decrease. Accordingly, chirality information exclusively stems from good specific binding, while curbed. benefits sensitivity versatility, enabling absolute wide variety molecules regardless size, functional groups, polarities, activities, scattering, number centers.

Language: Английский

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Molecularly Imprinted Polymer Based Sensors for Medical Applications

Sensors, Journal Year: 2019, Volume and Issue: 19(6), P. 1279 - 1279

Published: March 13, 2019

Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, real-time analysis. In recent years, efforts in sensor realm expanded promptly, it has already presented a broad range of applications the fields medical, pharmaceutical environmental applications, food safety, homeland security. particular, molecularly imprinted polymer based sensors created fascinating horizon for surface modification techniques by forming specific recognition cavities template molecules polymeric matrix. This method ensures versatility imprint variety biomolecules with different size, three dimensional structure, physical chemical features. contrast complex time-consuming laboratory methods, molecular imprinting offers rapid, sensitive, inexpensive, easy-to-use, highly selective approaches sensing, especially diagnosis, screening, theranostics. Due its robustness, stability, low-cost, reusability features, become very attractive modalities such minute structural changes structure biomolecules. review aims at discussing principle method, integration polymers tools, advances strategies methodologies, their future outlook on this concept.

Language: Английский

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Nanomaterials as sorbents for sample preparation in bioanalysis: A review

Analytica Chimica Acta, Journal Year: 2016, Volume and Issue: 958, P. 1 - 21

Published: Dec. 7, 2016

Language: Английский

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