Dual-template molecularly surface imprinted polymer on fluorescent metal-organic frameworks functionalized with carbon dots for ascorbic acid and uric acid detection

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2023, Volume and Issue: 291, P. 122340 - 122340

Published: Jan. 8, 2023

Language: Английский

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Recent Advances in Molecularly Imprinted Polymers for Antibiotic Analysis

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 335 - 335

Published: Jan. 1, 2023

The abuse and residues of antibiotics have a great impact on the environment organisms, their determination has become very important. Due to low contents, varieties complex matrices, effective recognition, separation enrichment are usually required prior determination. Molecularly imprinted polymers (MIPs), kind highly selective polymer prepared via molecular imprinting technology (MIT), used widely in analytical detection antibiotics, as adsorbents solid-phase extraction (SPE) recognition elements sensors. Herein, recent advances MIPs for antibiotic residue analysis reviewed. Firstly, several new preparation techniques detecting briefly introduced, including surface imprinting, nanoimprinting, living/controlled radical polymerization, multi-template multi-functional monomer dummy template imprinting. Secondly, SPE modes based summarized, namely packed SPE, magnetic dispersive matrix extraction, microextraction, stir-bar sorptive pipette-tip SPE. Thirdly, basic principles MIP-based sensors three sensing modes, electrochemical sensing, optical mass also outlined. Fourthly, research progress molecularly SPEs (MISPEs) electrochemical/optical/mass various environmental food samples since 2018 comprehensively reviewed, sulfonamides, quinolones, β-lactams so on. Finally, application prospects

Language: Английский

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Recent Development of Copper‐Based Nanozymes for Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Language: Английский

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Molecular Imprinting-Based SERS Detection Strategy for the Large-Size Protein Quantitation and Curbing Non-Specific Recognition

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(16), P. 6417 - 6425

Published: April 12, 2024

Molecular imprinting-based surface-enhanced Raman scattering (MI-SERS) sensors have shown remarkable potential from an academic standpoint. However, their practical applications, especially in the detection of large-size protein (≥10 nm), face challenges due to lack versatile sensing strategies and nonspecific fouling matrix species. Herein, we propose a reporter inspector mechanism (RRIM) implemented on protein-imprinted polydopamine (PDA) layer coated SERS active substrate. In RRIM, after recognition, permeability PDA imprinted cavities undergoes changes that are scrutinized by molecules. Target proteins can specifically bind fully occupy cavities, whereas species cannot. Then, molecules with suitable size introduced serve as both inspectors recognition status inducers signal, which only penetrate through vacant nonspecifically filled cavities. Consequently, signal exclusively originate specific binding target proteins, while is curbed. The RRIM enables reproducible quantitation cyanobacteria-specific model phycocyanin, at level down 2.6 × 10

Language: Английский

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Chiral Memory in Dynamic Transformation from Porous Organic Cages to Covalent Organic Frameworks for Enantiorecognition Analysis

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(11), P. 7594 - 7604

Published: March 11, 2024

The preservation of chirality during a transformation process, known as the "chiral memory" effect, has garnered significant attention across multiple research disciplines. Here, we first report retention original chiral structure dynamic covalent chemistry (DCC)-induced structural from porous organic cages into frameworks (COFs). A total six two-dimensional COFs constructed by entirely achiral building blocks were obtained through DCC-induced substitution linkers in homochiral cage (CC3-R or -S) using amine monomers. Homochirality these resulted construction 3-fold-symmetric benzene-1,3,5-methanimine cores with propeller-like configuration one single-handedness throughout cage-to-COF transformation. can be further utilized fluorescence sensors stationary phases for gas chromatography high enantioselectivity. present study thus highlighted great potential to expand scope functional materials via crystal-to-crystal memory effect.

Language: Английский

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Synergetic Multichiral Covalent Organic Framework for Enantioselective Recognition and Separation

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(3), P. 1380 - 1389

Published: Jan. 10, 2024

In enantiomer recognition and separation, a highly enantioselective approach with universal applicability is urgently desired but hard to realize, especially in the case of chiral molecules. To resolve trade-off between enantioselectivity universality, glutathione (GSH) methylated cyclodextrins (MCD)-functionalized covalent organic framework (GSH-MCD COF) porosity abundant surfaces presented that was designed synthesized for separation various enantiomers. As expected, GSH-MCD COF can be used as stationary phases enantiomers, including aromatic alcohols, acids, amides, amino performance versatility even superior some widely commercial chromatographic columns. Furthermore, shows high rapid identification enantiomers metabolites when coupling Raman spectroscopy. Molecular simulations suggest provides confined microenvironment peptides dictates capability. This work strategy synthesize synergetic multichiral achieve separations recognitions complex samples.

Language: Английский

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Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.

Language: Английский

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Emerging trends in sensors based on molecular imprinting technology: Harnessing smartphones for portable detection and recognition

Talanta, Journal Year: 2023, Volume and Issue: 268, P. 125283 - 125283

Published: Oct. 14, 2023

Language: Английский

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Advances and opportunities of polydopamine coating in biosensing: Preparation, functionality, and applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215564 - 215564

Published: Dec. 1, 2023

Language: Английский

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Assessing the greenification potential of cyclodextrin-based molecularly imprinted polymers for pesticides detection

Food Chemistry, Journal Year: 2023, Volume and Issue: 429, P. 136822 - 136822

Published: July 8, 2023

Language: Английский

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