Advanced Materials,
Journal Year:
2017,
Volume and Issue:
29(33)
Published: July 3, 2017
Photodynamic
therapy
(PDT),
which
relies
on
photosensitizers
(PS)
and
light
to
generate
reactive
oxygen
species
kill
cancer
cells
or
bacteria,
has
attracted
much
attention
in
recent
years.
PSs
with
both
bright
emission
efficient
singlet
generation
have
also
been
used
for
image-guided
PDT.
However,
simultaneously
achieving
effective
1
O2
generation,
long
wavelength
absorption,
stable
near-infrared
(NIR)
low
dark
toxicity
a
single
PS
remains
challenging.
In
addition,
it
is
well
known
that
when
traditional
are
made
into
nanoparticles,
they
encounter
quenched
fluorescence
reduced
production.
this
contribution,
these
challenging
issues
successfully
addressed
through
designing
the
first
photostable
photosensitizer
aggregation-induced
NIR
very
aggregate
state.
The
yielded
nanoparticles
show
centered
at
820
nm,
excellent
photostability,
good
biocompatibility,
negligible
vivo
toxicity.
Both
vitro
experiments
prove
candidates
photodynamic
anticancer
therapy.
Chemical Reviews,
Journal Year:
2019,
Volume and Issue:
119(8), P. 4881 - 4985
Published: April 11, 2019
Reactive
oxygen
species
(ROS)
play
an
essential
role
in
regulating
various
physiological
functions
of
living
organisms.
The
intrinsic
biochemical
properties
ROS,
which
underlie
the
mechanisms
necessary
for
growth,
fitness,
or
aging
organisms,
have
been
driving
researchers
to
take
full
advantage
these
active
chemical
contributing
medical
advances.
Thanks
remarkable
advances
nanotechnology,
great
varieties
nanomaterials
with
unique
ROS-regulating
explored
guide
temporospatial
dynamic
behaviors
ROS
biological
milieu,
contributes
emergence
a
new-generation
therapeutic
methodology,
i.e.,
nanomaterial-guided
vivo
evolution
therapy.
interdependent
relationship
between
and
their
corresponding
chemistry,
biology,
nanotherapy
leads
us
propose
concept
"ROS
science",
is
believed
be
emerging
scientific
discipline
that
studies
mechanisms,
effects,
nanotherapeutic
applications
ROS.
In
this
review,
state-of-art
concerning
recent
progresses
on
ROS-based
nanotherapies
summarized
detail,
emphasis
underlying
material
chemistry
by
are
generated
scavenged
improved
outcomes.
Furthermore,
key
issues
cross-disciplinary
fields
also
discussed,
aiming
unlock
innate
powers
optimized
efficacies.
We
expect
our
demonstration
evolving
field
will
beneficial
further
development
fundamental
researches
clinical
applications.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(21), P. 13454 - 13619
Published: Sept. 28, 2021
This
review
presents
a
robust
strategy
to
design
photosensitizers
(PSs)
for
various
species.
Photodynamic
therapy
(PDT)
is
photochemical-based
treatment
approach
that
involves
the
use
of
light
combined
with
light-activated
chemical,
referred
as
PS.
Attractively,
PDT
one
alternatives
conventional
cancer
due
its
noninvasive
nature,
high
cure
rates,
and
low
side
effects.
PSs
play
an
important
factor
in
photoinduced
reactive
oxygen
species
(ROS)
generation.
Although
concept
photosensitizer-based
photodynamic
has
been
widely
adopted
clinical
trials
bioimaging,
until
now,
our
surprise,
there
no
relevant
article
on
rational
designs
organic
PDT.
Furthermore,
most
published
articles
focused
nanomaterials
nanotechnology
based
traditional
PSs.
Therefore,
this
aimed
at
reporting
recent
strategies
develop
innovative
enhanced
therapy,
each
example
described
detail
instead
providing
only
general
overview,
typically
done
previous
reviews
PDT,
provide
intuitive,
vivid,
specific
insights
readers.
Angewandte Chemie International Edition,
Journal Year:
2018,
Volume and Issue:
57(36), P. 11522 - 11531
Published: May 29, 2018
Despite
its
clinical
promise,
photodynamic
therapy
(PDT)
suffers
from
a
key
drawback
associated
with
oxygen-dependent
nature,
which
limits
effective
use
against
hypoxic
tumors.
Moreover,
both
PDT-mediated
oxygen
consumption
and
microvascular
damage
further
increase
tumor
hypoxia
and,
thus,
impede
therapeutic
outcomes.
In
recent
years,
numerous
investigations
have
focused
on
strategies
for
overcoming
this
of
PDT.
These
efforts,
are
summarized
in
review,
produced
many
innovative
methods
to
avoid
the
PDT
hypoxia.
Journal of the American Chemical Society,
Journal Year:
2018,
Volume and Issue:
141(2), P. 849 - 857
Published: Dec. 13, 2018
Nanoformulations
that
can
respond
to
the
specific
tumor
microenvironment
(TME),
such
as
a
weakly
acidic
pH,
low
oxygen,
and
high
glutathione
(GSH),
show
promise
for
killing
cancer
cells
with
minimal
invasiveness
specificity.
In
this
study,
we
demonstrate
self-assembled
copper-amino
acid
mercaptide
nanoparticles
(Cu-Cys
NPs)
in
situ
glutathione-activated
H2O2-reinforced
chemodynamic
therapy
drug-resistant
breast
cancer.
After
endocytosis
into
cells,
Cu-Cys
NPs
could
first
react
local
GSH,
induce
GSH
depletion,
reduce
Cu2+
Cu+.
Subsequently,
generated
Cu+
would
H2O2
generate
toxic
hydroxyl
radicals
(·OH)
via
Fenton-like
reaction,
which
has
fast
reaction
rate
TME,
are
responsible
tumor-cell
apoptosis.
Due
concentration
sequentially
triggers
redox
reactions,
exhibited
relatively
cytotoxicity
whereas
normal
were
left
alive.
The
vivo
results
also
proved
efficiently
inhibited
without
causing
obvious
systemic
toxicity.
As
novel
copper
nanoformulation
responsive
these
may
have
great
potential
therapy.
Advanced Healthcare Materials,
Journal Year:
2019,
Volume and Issue:
8(13)
Published: May 8, 2019
Abstract
As
an
emerging
clinical
modality
for
cancer
treatment,
photodynamic
therapy
(PDT)
takes
advantage
of
the
cytotoxic
activity
reactive
oxygen
species
(ROS)
that
are
generated
by
light
irradiating
photosensitizers
(PSs)
in
presence
(O
2
).
However,
further
advancements
including
tumor
selectivity
and
ROS
generation
efficiency
still
required.
Substantial
efforts
devoted
to
design
synthesize
smart
PSs
with
optimized
properties
achieving
a
desirable
therapeutic
efficacy.
This
review
summarizes
recent
progress
developing
intelligent
efficient
PDT,
ranging
from
single
molecules
delicate
nanomaterials.
The
strategies
improve
through
optimizing
photoinduced
electron
transfer
energy
processes
highlighted.
Moreover,
approaches
combine
PDT
other
therapeutics
(e.g.,
chemotherapy,
photothermal
therapy,
radiotherapy)
targeted
delivery
cells
or
tissue
introduced.
main
challenges
application
also
discussed.
Chemical Society Reviews,
Journal Year:
2017,
Volume and Issue:
46(12), P. 3830 - 3852
Published: Jan. 1, 2017
Nanovehicles
can
efficiently
carry
and
deliver
anticancer
agents
to
tumour
sites.
Compared
with
normal
tissue,
the
microenvironment
has
some
unique
properties,
such
as
vascular
abnormalities,
hypoxia
acidic
pH.
There
are
many
types
of
cells,
including
macrophages,
immune
fibroblast
fed
by
defective
blood
vessels
in
solid
tumour.
Exploiting
benefit
design
nanoparticles
for
enhanced
therapeutic
effectiveness.
In
this
review
article,
we
summarized
recent
progress
various
nanoformulations
cancer
therapy,
a
special
emphasis
on
stimuli-responsive
ones.
Numerous
modulation
strategies
promising
efficacy
have
also
been
highlighted.
Future
challenges
opportunities
consideration
discussed
detail.
We
believe
that
these
offer
good
chance
practical
translation
nanoparticle
formulas
into
clinic.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(45)
Published: July 31, 2018
Photodynamic
therapy
is
arising
as
a
noninvasive
treatment
modality
for
cancer
and
other
diseases.
One
of
the
key
factors
to
determine
therapeutic
function
efficiency
photosensitizers
(PSs).
Opposed
traditional
PSs,
which
show
quenched
fluorescence
reduced
singlet
oxygen
production
in
aggregate
state,
PSs
with
aggregation-induced
emission
(AIE)
exhibit
enhanced
strong
photosensitization
ability
nanoparticles.
Here,
design
principles
AIE
their
biomedical
applications
are
discussed
detail,
starting
summary
followed
by
comparison
between
highlight
various
strategies
unique
features
latter.
Subsequently,
photodynamic
cell
ablation,
bacteria
killing,
image-guided
using
charged
PS
molecular
probes,
nanoparticles
examples.
These
studies
have
demonstrated
great
potential
effective
theranostic
agents
treat
tumor
or
bacterial
infection.
This
review
hopefully
will
spur
more
research
interest
future
translational
research.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 1111 - 1137
Published: Nov. 27, 2020
This
review
summarizes
the
recent
development
of
second
near-infrared
photothermal
combinational
nanotheranostics
for
cancer,
infectious
diseases
and
regenerative
medicine.
