Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer

ACS Nano, Journal Year: 2017, Volume and Issue: 11(5), P. 4463 - 4474

Published: March 31, 2017

While immunotherapy has become a highly promising paradigm for cancer treatment in recent years, it long been recognized that photodynamic therapy (PDT) the ability to trigger antitumor immune responses. However, conventional PDT triggered by visible light limited penetration depth, and its generated responses may not be robust enough eliminate tumors. Herein, upconversion nanoparticles (UCNPs) are simultaneously loaded with chlorin e6 (Ce6), photosensitizer, imiquimod (R837), Toll-like-receptor-7 agonist. The obtained multitasking UCNP-Ce6-R837 under near-infrared (NIR) irradiation enhanced tissue depth would enable effective destruction of tumors generate pool tumor-associated antigens, which presence those R837-containing as adjuvant able promote strong More significantly, combination cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) checkpoint blockade only shows excellent efficacy eliminating exposed NIR laser but also results immunities inhibit growth distant left behind after treatment. Furthermore, such strategy long-term memory function protect treated mice from tumor cell rechallenge. This work presents an immune-stimulating UCNP-based CTLA-4 effectively destroy primary exposure, can hardly reached light, prevent reoccurrence via effect.

Language: Английский

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Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(25), P. 9868 - 9886

Published: March 4, 2020

Abstract The concept of aggregation‐induced emission (AIE) has opened new opportunities in many research fields. Motivated by the unique feature AIE fluorogens (AIEgens), during past decade, molecular probes and nanoparticle (NP) have been developed for sensing, imaging theranostic applications with excellent performance outperforming conventional fluorescent probes. This Review summarizes latest advancement NP their emerging biomedical applications. Special focus is to reveal how are evolved development multifunctional AIEgens, strategies overcome limitations traditional more translational via fluorescence imaging, photoacoustic image‐guided photodynamic/photothermal therapy. outlook discusses challenges future AIEgens advance field.

Language: Английский

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Advances in nanomaterials for photodynamic therapy applications: Status and challenges

Biomaterials, Journal Year: 2020, Volume and Issue: 237, P. 119827 - 119827

Published: Jan. 27, 2020

Language: Английский

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Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

ACS Nano, Journal Year: 2019, Volume and Issue: 13(4), P. 4267 - 4277

Published: March 22, 2019

The integration of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) holds great promise for enhanced anticancer effects. Herein, we report biodegradable cancer cell membrane-coated mesoporous copper/manganese silicate nanospheres (mCMSNs) with homotypic targeting ability to the lines ROS generation through singlet (1O2) production glutathione (GSH)-activated Fenton reaction, showing excellent CDT/PDT synergistic therapeutic We demonstrate that mCMSNs are able relieve tumor hypoxia microenvironment by catalytic decomposition endogenous H2O2 O2 further react produce toxic 1O2 a 635 nm laser irradiation. GSH-triggered biodegradation can simultaneously generate Fenton-like Cu+ Mn2+ ions deplete GSH efficient hydroxyl radical (•OH) production. specific recognition cells were also revealed. Notably, relieving depletion disrupts (TME) cellular antioxidant defense system, achieving exceptional cancer-targeting effects in vitro vivo. growth was significantly inhibited. Moreover, released act as an advanced contrast agent magnetic resonance imaging (MRI). Thus, together photosensitizers, provider MRI along modulating TME allow realize MRI-monitored therapy. It provides paradigm rationally design TME-responsive ROS-involved strategies based on single polymetallic nanomaterial

Language: Английский

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Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

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Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Aug. 14, 2018

Reactive oxygen species (ROS)-induced apoptosis is a promising treatment strategy for malignant neoplasms. However, current systems are highly dependent on status and/or external stimuli to generate ROS, which greatly limit their therapeutic efficacy particularly in hypoxic tumors. Herein, we develop biomimetic nanoflower based self-assembly of nanozymes that can catalyze cascade intracellular biochemical reactions produce ROS both normoxic and conditions without any stimuli. In our formulation, PtCo nanoparticles firstly synthesized used direct the growth MnO2. By adjusting ratio reactants, highly-ordered MnO2@PtCo nanoflowers with excellent catalytic efficiency obtained, where behaves as oxidase mimic MnO2 functions catalase mimic. this way, well-defined not only relieve condition but also induce cell significantly through ROS-mediated mechanism, thereby resulting remarkable specific inhibition tumor growth.

Language: Английский

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Near-Infrared Light-Initiated Molecular Superoxide Radical Generator: Rejuvenating Photodynamic Therapy against Hypoxic Tumors

Journal of the American Chemical Society, Journal Year: 2018, Volume and Issue: 140(44), P. 14851 - 14859

Published: Oct. 17, 2018

Hypoxia, a quite universal feature in most solid tumors, has been considered as the "Achilles' heel" of traditional photodynamic therapy (PDT) and substantially impairs overall therapeutic efficacy. Herein, we develop near-infrared (NIR) light-triggered molecular superoxide radical (O2-•) generator (ENBS-B) to surmount this intractable issue, also reveal its detailed O2-• action mechanism underlying antihypoxia effects, confirm application for vivo targeted hypoxic tumor ablation. Photomediated generation study shows that, even under severe environment (2% O2), ENBS-B can generate considerable through type I photoreactions, partial is transformed high toxic OH· SOD-mediated cascade reactions. These radicals synergistically damage intracellular lysosomes, which subsequently trigger cancer cell apoptosis, presenting robust PDT potency. In vitro coculture model benefiting from biotin ligand, achieves 87-fold higher cellular uptake cells than normal cells, offering opportunities personalized medicine. Following intravenous administration, able specifically target neoplastic tissues completely suppresses growth at low light-dose irradiation. As such, postulated work will extend options excellent agents clinical therapy.

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(21)

Published: March 25, 2019

Abstract Over the past 3 years, glucose oxidase (GOx) has aroused great research interest in context of cancer treatment due to its inherent biocompatibility and biodegradability, unique catalytic properties against β‐ d ‐glucose. GOx can effectively catalyze oxidation into gluconic acid hydrogen peroxide. This process depletes oxygen levels, resulting elevated acidity, hypoxia, oxidative stress tumor microenvironment. All these changes be readily harnessed develop a multimodal synergistic therapy by combining with other therapeutic approaches. Herein, representative studies GOx‐instructed are introduced, their mechanisms discussed systematically. The current challenges future prospects advance development GOx‐based nanomedicines this cutting‐edge area highlighted.

Language: Английский

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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Theranostics, Journal Year: 2020, Volume and Issue: 10(10), P. 4557 - 4588

Published: Jan. 1, 2020

In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors diseased regions increase specificity of drug delivery. Currently, numerous nanocarriers have engineered with changes responding external stimuli, such as ultrasound, thermal, light magnetic field, well internal including pH, redox potential, hypoxia enzyme, etc. Nanocarriers respond stimuli tumor microenvironments or inside cancer cells for on-demanded delivery accumulation, controlled release, activation bioactive compounds, probes targeting ligands, size, charge conformation conversion, etc., leading sensing signaling, overcoming multidrug resistance, accurate diagnosis precision therapy. This review summarized general strategies developing advances, presented their applications delivery, imaging, therapy theranostics, illustrated clinical translation made prospects.

Language: Английский

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