Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 38 - 71

Published: Nov. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Language: Английский

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Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

Advanced Science, Journal Year: 2018, Volume and Issue: 5(10)

Published: July 19, 2018

Great and interdisciplinary research efforts have been devoted to the biomedical applications of 2D materials because their unique planar structure prominent physiochemical properties. Generally, ceramic-based biomaterials, fabricated by high-temperature solid-phase reactions, are preferred as bone scaffolds in hard tissue engineering controllable biocompatibility satisfactory mechanical property, but potential disease theranostics paid much less attention, mainly due lack related material functionalities for possibly entering circulating within vascular system. The emerging MXenes, a family ultrathin atomic nanosheet derived from MAX phase ceramics, currently booming novel inorganic nanosystems biologic applications. metallic conductivity, hydrophilic nature, other performances make it possible MXenes meet strict requirements biomedicine. This work introduces very recent progress paradigms state-of-the-art applications, focusing on design/synthesis strategies, therapeutic modalities, diagnostic imaging, biosensing, antimicrobial, biosafety issues. It is highly expected that elaborately engineered nanosheets will become one most attractive biocompatible nanoplatforms multiple extensive profit clinical translation nanomedicine.

Language: Английский

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Porphyrin‐Based Metal–Organic Frameworks for Biomedical Applications

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(10), P. 5010 - 5035

Published: Jan. 28, 2020

Abstract Porphyrins and porphyrin derivatives have been widely explored for various applications owing to their excellent photophysical electrochemical properties. However, inherent shortcomings, such as instability self‐quenching under physiological conditions, limit biomedical applications. In recent years, metal–organic frameworks (MOFs) received increasing attention. The construction of porphyrin‐based MOFs by introducing molecules into or using porphyrins organic linkers form can combine the unique features well overcome limitations porphyrins. This Review summarizes important synthesis strategies including porphyrin@MOFs, porphyrinic MOFs, composite highlights achievements progress in development tumor therapy biosensing. Finally, challenges prospects presented this class emerging materials are discussed.

Language: Английский

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Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Small, Journal Year: 2018, Volume and Issue: 15(1)

Published: Nov. 20, 2018

Abstract Phototherapy including photothermal therapy (PTT) and photodynamic (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional include easy recognition immune system, rapid clearance from blood circulation, low accumulation in target sites. Cell‐membrane coating emerged as a potential way overcome these limitations, owing abundant proteins on surface of cell membranes that can be inherited membrane–camouflaged nanoparticles. This review summarizes recent advances development biomimetic nanoparticles phototherapy. Different sources used coat uisng different approaches. After cell‐membrane coating, photophysical properties original remain nearly unchanged; however, coated are equipped with additional physiological features escape, vivo prolonged circulation time, homologous targeting, depending sources. Moreover, membrane ablated under laser irradiation, leading drug release thus synergetic By combining other supplementary normalize tumor microenvironment, further enhance therapeutic efficacy against cancer.

Language: Английский

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A Novel Top‐Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging‐Guided Cancer Therapy

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(36)

Published: July 18, 2018

Abstract Single atom nonmetal 2D nanomaterials have shown considerable potential in cancer nanomedicines, owing to their intriguing properties and biocompatibility. Herein, ultrathin boron nanosheets (B NSs) are prepared through a novel top‐down approach by coupling thermal oxidation etching liquid exfoliation technologies, with controlled nanoscale thickness. Based on the PEGylated B NSs, new photonic drug delivery platform is developed, which exhibits multiple promising features for therapy imaging, including: i) efficient NIR‐light‐to‐heat conversion high photothermal efficiency of 42.5%, ii) drug‐loading capacity triggered release NIR light moderate acidic pH, iii) strong accumulation at tumor sites, iv) multimodal imaging (photoacoustic, photothermal, fluorescence imaging), v) complete ablation excellent As far as it known, this first report fabrication NSs combined exfoliation, well application imaging‐guided platform. The newly also expected provide robust useful nanoplatform various biomedical applications.

Language: Английский

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Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: April 20, 2020

Despite its growing promise in cancer treatment, ferrotherapy has low therapeutic efficacy due to compromised Fenton catalytic efficiency tumor milieu. We herein report a hybrid semiconducting nanozyme (HSN) with high photothermal conversion for photoacoustic (PA) imaging-guided second near-infrared ferrotherapy. HSN comprises an amphiphilic polymer as converter, PA emitter and iron-chelating catalyst. Upon photoirradiation, generates heat not only induce cytotoxicity but also enhance reaction. The increased ·OH generation promotes both ferroptosis apoptosis, oxidizes (42 nm) transforms it into tiny segments (1.7 elevated intratumoral permeability. non-invasive seamless synergism leads amplified effects including deep ablation depth (9 mm), reduced expression of metastasis-related proteins inhibition metastasis from primary distant organs. Thereby, our study provides generalized strategy compensate phototherapeutics complete regression.

Language: Английский

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Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy

ACS Nano, Journal Year: 2016, Volume and Issue: 10(11), P. 10245 - 10257

Published: Oct. 24, 2016

Photothermal therapy (PTT) is attracting increasing interest and becoming more widely used for skin cancer in the clinic, as a result of its noninvasiveness low systemic adverse effects. However, there an urgent need to develop biocompatible PTT agents, which enable accurate imaging, monitoring, diagnosis. Herein, Gd-integrated CuS nanotheranostic agent (Gd:CuS@BSA) was synthesized via facile environmentally friendly biomimetic strategy, using bovine serum albumin (BSA) biotemplate at physiological temperature. The as-prepared Gd:CuS@BSA nanoparticles (NPs) with ultrasmall sizes (ca. 9 nm) exhibited high photothermal conversion efficiency good photostability under near-infrared (NIR) laser irradiation. With doped Gd species strong tunable NIR absorbance, NPs demonstrate prominent tumor-contrasted imaging performance both on photoacoustic magnetic resonance modalities. subsequent Gd:CuS@BSA-mediated shows efficacy their potent absorption efficiency. immune response triggered by preliminarily explored. In addition, toxicity studies vitro vivo verify that qualify agents. A biodistribution study demonstrated can undergo hepatic clearance from body. This highlights practicality versatility albumin-mediated mineralization also suggests bioinspired possess promising guidance effective tumor ablation properties, spatial resolution deep tissue penetration.

Language: Английский

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Entry of nanoparticles into cells: the importance of nanoparticle properties

Polymer Chemistry, Journal Year: 2017, Volume and Issue: 9(3), P. 259 - 272

Published: Dec. 18, 2017

Knowledge of the interactions between nanoparticles (NPs) and cell membranes is great importance for design safe efficient nanomedicines.

Language: Английский

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Engineering Persistent Luminescence Nanoparticles for Biological Applications: From Biosensing/Bioimaging to Theranostics

Accounts of Chemical Research, Journal Year: 2018, Volume and Issue: 51(5), P. 1131 - 1143

Published: April 17, 2018

ConspectusPersistent luminescence nanoparticles (PLNPs) are unique optical materials emitting long-lasting after ceasing excitation. Such a feature allows detection without constant external illumination to avoid the interferences of autofluorescence and scattering light from biological fluids tissues. Besides, near-infrared (NIR) PLNPs have advantages deep penetration reactivation persistent (PL) by red or NIR light. These features make application NIR-emitting in long-term bioimaging no longer limited lifetime PL. To take full advantage for applications, versatile strategies bridging system become increasingly significant design PLNPs-based nanoprobes.In this Account, we summarize our systematic achievements applications biosensing/bioimaging theranostics with emphasizing engineering fabricating specific nanoprobes. We surface manipulating energy transfer as major principles various nanoprobes based on nature interactions between targets. developed target-induced formation interruption fluorescence resonance systems autofluorescence-free biosensing imaging cancer biomarkers. decorated single dual targeting ligands tumor-targeted imaging, integrated other modal agents into multimodal imaging. also employed functionalization biomedical including chemotherapy, photodynamic therapy, photothermal stem cells tracking PL imaging-guided gene therapy. modified multiple functional units achieve challenging metastatic tumor theranostics. The proposed principle comprehensive show great potential guiding promoting further development fields science medicine.We conclude Account outlining future directions promote practical PLNPs. novel protocols synthesis small-size, monodisperse, water-soluble high intensity superlong afterglow vibrant In-depth theories evidence mechanism highly desired improvement their performance. Furthermore, irradiations tissue penetrating depth limit, such X-ray, encouraged use storage re-excitation PLNPs, enabling vivo integrating X-ray sensitized theranostic techniques computed tomography radiotherapy. Last but not least, brand new hybrids nanomaterials bright prospect accurate diagnosis efficient treatment diseases besides tumors.

Language: Английский

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