Skin Pigmentation‐Inspired Polydopamine Sunscreens

Advanced Functional Materials, Journal Year: 2018, Volume and Issue: 28(33)

Published: June 12, 2018

Abstract Commercial sunscreens usually rely on multiple component formulas against solar irradiation, including UV filters, antioxidants, and nanomaterial matrices. While many efforts are devoted, concern has arisen that the effectiveness safety issues of most largely limited by their complex formulations, photostability, toxicity. Inspired skin pigmentation as primary photoprotective mechanism in human body, novel sunscreen products based polydopamine (PDA) gels, with a bioinspired protection concept improved capacities, were rationally designed facilely prepared. The diverse formula those gels can be achieved use PDA nanoparticle, kind naturally melanin mimics, to complex/conjugate different polymers. resulting bioadhesive, water resistant, nonskin penetration, yet directly removed towel wiping. They also perform promising features superior shielding properties, high vitro vivo efficiencies, nonphototoxicity, nonirritating nature. These materials an initial proof‐of‐concept study described it is proposed this class will useful for incident where simple, safe, efficient still highly desirable.

Language: Английский

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Conversion of oxybenzone sunscreen to phototoxic glucoside conjugates by sea anemones and corals

Science, Journal Year: 2022, Volume and Issue: 376(6593), P. 644 - 648

Published: May 5, 2022

The reported toxicity of oxybenzone-based sunscreens to corals has raised concerns about the impacts ecotourist-shed on already weakened by global stressors. However, oxybenzone’s mechanism(s) are not understood, hampering development safer sunscreens. We found that oxybenzone caused high mortality a sea anemone under simulated sunlight including ultraviolet (UV) radiation (290 370 nanometers). Although itself protected against UV-induced photo-oxidation, both and mushroom coral formed oxybenzone–glucoside conjugates were strong photo-oxidants. Algal symbionts sequestered these conjugates, correlated with conjugate concentrations in animal cytoplasm. Higher anemones lacked suggests an enhanced risk from bleached rising temperatures. Because many commercial contain structurally related chemicals, understanding metabolite phototoxicity should facilitate coral-safe products.

Language: Английский

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Polyphenolic sunscreens for photoprotection

Green Chemistry, Journal Year: 2022, Volume and Issue: 24(9), P. 3605 - 3622

Published: Jan. 1, 2022

This paper strives to summarize the recent advances and current highlights of photoprotective polyphenolic sunscreens including structural functional relationships, design principle, UV-protection mechanism evaluation system.

Language: Английский

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Endogenous Photosensitizers in Human Skin

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(16), P. 9720 - 9785

Published: July 17, 2023

Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced transformations biological systems. Understanding their mode of action is essential for advancing fields such as photomedicine, photoredox catalysis, environmental science, the development sun care products. This review offers comprehensive analysis endogenous human skin, investigating connections between electronic excitation subsequent activation or damage organic biomolecules. We gather physicochemical photochemical properties key examine relationships chemical reactivity, location within primary biochemical events following solar radiation exposure, along with influence on skin physiology pathology. An important take-home message this that photosensitization allows visible light UV-A to have large effects skin. The presented here unveils potential causes continuous increase global cancer cases emphasizes limitations current protection approaches.

Language: Английский

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Materials Science Challenges in Skin UV Protection: A Review

Photochemistry and Photobiology, Journal Year: 2019, Volume and Issue: 96(4), P. 779 - 797

Published: Dec. 30, 2019

UV radiation is one of the critical environmental stress factors for human skin, which can trigger various problems such as pruritus, burning, erythema, premature skin aging and cancer. Hence, protection has become an indispensable daily routine use topical sunscreen products rapidly increasing. However, there are emerging concerns over efficiency safety existing chemical physical filters used in consumer products. Furthermore, no universally approved method assessing sun regardless immediate end user need to develop safer that afford broad-spectrum photoprotection. It evident current organic inorganic have significant unfavorable impacts on human, environmental, marine safety. Therefore, effective alternative should be established. This article comprehensively reviews properties, safety, health ecological including TiO2 ZnO nanoparticles well limitations testing protocols guidelines provided by major regulatory bodies. The photoreactivity remains a challenge, it crucial new ingredients, not only protect consumer, but also environment.

Language: Английский

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Natural components in sunscreens: Topical formulations with sun protection factor (SPF)

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 134, P. 111161 - 111161

Published: Dec. 24, 2020

Artificial sunscreens are already gaining traction in order to protect the skin from sunburns, photoaging and photocarcinogenesis. However, efficacy safety of most artificial sunscreen constituents hindered by their photostability, toxicity damage marine ecosystems. Natural selection evolution have ensured that plants animals developed effective protective mechanisms against deleterious side effects oxidative stress ultraviolet radiation (UV). Hence, natural antioxidants such as sun blockers drawing considerable attention. The exact mechanism which components act molecules has not been clearly established. conjugated π system is reported play an important role protecting vital genetic material within organism. Compared sunscreens, with strong UV absorptive capacities largely limited low specific extinction value inability spread large-scale cosmetic applications. Previous studies documented exert photoprotective (such improved elasticity hydration, texture, wrinkles) through antioxidant effects, regulation UV-induced inflammation, barrier impairment aging. This review focuses on topical formulations protection factor (SPF). Lignin, melanin, silymarin other ingredients added high nature without any physical or chemical filters. paper also provides a reference for adopting novel technical measures (extracting content components, changing type solution, optimizing formulation, applying Nano technology, et al) design prepare equated commercial formulations. Another strategy add plants, animals, microorganisms organisms special enhancer modifier reinforce SPF values. Although established, elucidated.

Language: Английский

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Bioinspired Lignin-Polydopamine Nanocapsules with Strong Bioadhesion for Long-Acting and High-Performance Natural Sunscreens

Biomacromolecules, Journal Year: 2020, Volume and Issue: 21(8), P. 3231 - 3241

Published: July 14, 2020

UV filters that contain one or two aromatic rings in conventional sunscreens generally have a poor photo- and thermal stability can easily penetrate through stratum corneum dermis into the blood vessel, thus causing potential health-threatening issues. Herein, series of bioinspired photostable biocompatible polydopamine-grafted lignin (AL-PDA) with strong bioadhesion been synthesized free radical addition dopamine (DA) alkali (AL). AL-PDA was used to emulsify organic further cross-linked form nanocapsules ultrasonic cavitation. The retention rate optimal on skin surface reached 87% after thorough rinse water negligible penetration observed, which demonstrates their excellent property. Force measurements using atomic force microscopy (AFM) quantitatively revealed adhesion between skin. An average DA grafting number 4 would be required endow suitable water-penetration resistance. were as sole active ingredient for formulating sunscreen, whose sun protection factor (SPF) value could reach 195.33 dosage ∼10 wt % lasting over 8 h under radiation. as-prepared possess antioxidant capacity biocompatibility, ensuring superior performance safe use sunscreen. This work provides new insights development biomass advanced function materials high-end products.

Language: Английский

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Mussel-inspired biocompatible polydopamine/carboxymethyl cellulose/polyacrylic acid adhesive hydrogels with UV-shielding capacity

Cellulose, Journal Year: 2021, Volume and Issue: 28(3), P. 1527 - 1540

Published: Jan. 2, 2021

Language: Английский

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Sunscreens and their usefulness: have we made any progress in the last two decades?

Photochemical & Photobiological Sciences, Journal Year: 2021, Volume and Issue: 20(2), P. 189 - 244

Published: Feb. 1, 2021

Language: Английский

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Role Evaluation of Active Groups in Lignin on UV-Shielding Performance

ACS Sustainable Chemistry & Engineering, Journal Year: 2022, Volume and Issue: 10(36), P. 11856 - 11866

Published: Aug. 30, 2022

The contribution of the active groups in lignin to ultraviolet (UV)-shielding performance still remains unclear. In this study, we employed 16 model compounds and theoretical calculations ascertain different functional UV-shielding performance. These results showed that order on was −C═C–CHO > −C═C–COOH −C═C–CH2OH −C═C quinone −COOH −OCH3 ≈ −OH. Moreover, synergism between para-substituted electron-donating group −OH electron-withdrawing allyl aromatic ring played a major role models, whereas additive effect meta/ortho-substituted secondary role. Furthermore, found hydrophile–lipophile balance (HLB) value models also greatly affected sunscreen protection factor (SPF) model-based sunscreens. A closer HLB 8.89 corresponded with higher SPF sunscreen. commercial photoprotective ingredient ethylhexyl methoxycinnamate (EHMC) had synergistic caused by π–π stacking interaction parallel-displaced stacked rings EHMC. Additionally, UV irradiation test these sunscreens prepared using EHMC exhibited good photostability.

Language: Английский

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