3d Transition Metals for C–H Activation

Chemical Reviews, Journal Year: 2018, Volume and Issue: 119(4), P. 2192 - 2452

Published: Nov. 27, 2018

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these functionalizations required precious 4d or 5d transition metal catalysts. Given cost-effective sustainable nature earth-abundant first row metals, development less toxic, inexpensive 3d catalysts gained considerable recent momentum a significantly more environmentally-benign economically-attractive alternative. Herein, we provide comprehensive overview on until summer 2018.

Language: Английский

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Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

Chemical Reviews, Journal Year: 2018, Volume and Issue: 119(3), P. 1855 - 1969

Published: Dec. 24, 2018

In this review, we summarize the origin and advancements of iridium-catalyzed asymmetric allylic substitution reactions during past two decades. Since first report in 1997, Ir-catalyzed have attracted intense attention due to their exceptionally high regio- enantioselectivities. been significantly developed recent years many respects, including ligand development, mechanistic understanding, substrate scope, application synthesis complex functional molecules. an explicit outline ligands, mechanism, scope nucleophiles, applications is presented.

Language: Английский

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Organic synthesis with the most abundant transition metal–iron: from rust to multitasking catalysts

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(1), P. 243 - 472

Published: Jan. 1, 2021

The promising aspects of iron in synthetic chemistry are being explored for three-four decades as a green and eco-friendly alternative to late transition metals. This present review unveils these rich iron-chemistry towards different transformations.

Language: Английский

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Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6307 - 6416

Published: Jan. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Language: Английский

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Transition Metal‐Catalyzed Intermolecular Cascade C−H Activation/Annulation Processes for the Synthesis of Polycycles

Chemistry - A European Journal, Journal Year: 2020, Volume and Issue: 27(1), P. 121 - 144

Published: June 12, 2020

Abstract Polycycles are abundantly present in numerous advanced chemicals, functional materials, bioactive molecules and natural products. However, the strategies for synthesis of polycycles limited to classical reactions transition metal‐catalyzed cross‐coupling reactions, requiring pre‐functionalized starting materials lengthy synthetic operations. The emergence novel approaches shows great promise fields organic/medicinal/materials chemistry. Among them, C−H activation followed by intermolecular annulation prevail, due their straightforward manner with high atom‐ step‐economy, providing rapid, concise efficient methods construction diverse polycycles. Several have been developed polycycles, relying on sequential multiple activation/annulation, or combination activation/annulation further interaction a proximal group, merger cycloaddition reaction, situ formation directing group. These attractive, efficient, step‐ atom‐economic from commercially available materials. This Minireview will provide an introduction helping researchers discover indirect connections reveal hidden opportunities. It also promote discovery activation.

Language: Английский

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C–H Functionalization of Aromatic Amides

Advanced Synthesis & Catalysis, Journal Year: 2019, Volume and Issue: 362(7), P. 1406 - 1446

Published: Dec. 9, 2019

Abstract Since the beginning of 21 st century, significant progress has been made in transition metal‐catalyzed C–H functionalization aromatic amides. The achievements this field have mainly focused on ortho (proximal) functionalization, there far fewer reports remote and para‐ meta‐ selective functionalizations remain a major challenge. Interestingly, are few related comments field. In published cases, scope report is relatively narrow, either to comment specific directing group or summarize reaction site. Herein, for first time, we comprehensively summarized This review divided into three parts: ortho‐ , amides, subdivided according type catalyst. groups, types, conditions, mechanism applications corresponding reactions discussed detail. magnified image

Language: Английский

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Photoinduced C–H arylation of 1,3-azoles via copper/photoredox dual catalysis

Chemical Science, Journal Year: 2024, Volume and Issue: 15(19), P. 7293 - 7299

Published: Jan. 1, 2024

The photo-induced azole C–H arylation was realized with a dual-catalytic copper-based system. Exceedingly mild reaction conditions at ambient temperature and visible light irradiation enabled broad scope high functional group tolerance.

Language: Английский

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Recent Development on Cp*Ir(III)‐Catalyzed C−H Bond Functionalization

ChemCatChem, Journal Year: 2019, Volume and Issue: 12(9), P. 2358 - 2384

Published: Dec. 18, 2019

Abstract Selective functionalization of ubiquitous C−H bonds molecules would provide novel retrosynthetic insights and powerful tools for the rapid construction molecular complexity. In this context, Cp*Ir(III) complexes have exhibited versatile reactivity towards selective conversion bonds, with key features that include use readily transformable raw materials, great selectivity (chemo‐, stereo‐ regio‐), high efficiency, mild reaction conditions they enable late‐stage modification complex molecules. Recently, catalysis has achieved a broad range reactions such as multiple dehydrogenations stereoselective C−X bond formations. These advancements are valuable to organometallic chemists efficient synthesis functionalized architectures.

Language: Английский

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Hydroxyl Group‐Prompted and Iridium(III)‐Catalyzed Regioselective C−H Annulation of N‐phenoxyacetamides with Propargyl Alcohols

Advanced Synthesis & Catalysis, Journal Year: 2018, Volume and Issue: 360(13), P. 2470 - 2475

Published: April 27, 2018

Abstract An efficient, mild and redox‐neutral iridium(III)‐catalyzed C−H annulation of N ‐phenoxyacetamides for the regioselective synthesis benzofurans has been developed by employing tertiary propargyl alcohols as versatile coupling partners. The computed results together with experimental data revealed that hydroxyl group acts key factor in controlling regioselectivity tuning reactivity. magnified image

Language: Английский

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Applications of Transition‐Metal‐Catalyzed Asymmetric Allylic Substitution in Total Synthesis of Natural Products: An Update

The Chemical Record, Journal Year: 2020, Volume and Issue: 21(1), P. 29 - 68

Published: Nov. 18, 2020

Abstract Metal‐catalyzed asymmetric allylic substitution (AAS) reaction is one of the most synthetically useful reactions catalyzed by metal complexes for formation carbon‐carbon and carbon‐heteroatom bonds. It comprises substrates with a wide range nucleophiles or S N 2′‐type substitution, which results in above‐mentioned bonds high levels enantioselective induction. AAS tolerates broad functional groups, thus has been successfully applied synthesis optically pure compounds. This extensively used total several complex molecules, especially natural products. In this review, we try to highlight applications (Pd, Ir, Mo, Cu)‐catalyzed biologically active products, as key step, updating subject from 2003 till date.

Language: Английский

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