Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2024,
Volume and Issue:
23(3)
Published: May 1, 2024
Recently,
the
role
of
gut
microbiota
in
metabolic
health,
immunity,
behavioral
balance,
longevity,
and
intestine
comfort
has
been
object
several
studies
from
scientific
communities.
They
were
encouraged
by
a
growing
interest
food
industries
consumers
toward
novel
fermented
ingredients
formulations
with
powerful
biological
effects,
such
as
pre,
pro,
postbiotic
products.
Depending
on
selected
strains,
operating
conditions,
addition
suitable
reagents
or
enzymes,
equipment,
reactor
configurations,
functional
compounds
high
bioactivity,
short-chain
fatty
acids,
gamma-aminobutyric
acid,
bioactive
peptides,
serotonin,
can
be
enhanced
and/or
produced
through
fermentation
vegetable
matrices.
Otherwise,
their
formation
also
promoted
directly
after
dietary
intake
foods:
In
this
case,
will
aim
to
increase
content
precursor
substances,
indigestible
fibers,
polyphenols,
some
amino
resistant
starch,
which
potentially
metabolized
endogenous
microorganisms
converted
healthy
molecules.
This
review
provides
an
overview
main
components
currently
investigated
literature
associated
health
benefits.
The
current
state
art
about
technology
promising
functionalization
tool
promote
direct
indirect
gut-health-enhancing
was
deepened,
highlighting
importance
optimizing
microorganism
selection,
system
setups,
process
conditions
according
target
compound
interest.
collected
data
suggested
possibility
gaining
products
rich
molecules
without
performing
additional
extraction
purification
stages,
are
needed
when
conventional
culture
broths
used.
Molecules,
Journal Year:
2019,
Volume and Issue:
24(15), P. 2678 - 2678
Published: July 24, 2019
Gamma-aminobutyric
acid
(Gaba)
is
a
non-proteinogenic
amino
that
widely
present
in
microorganisms,
plants,
and
vertebrates.
So
far,
Gaba
well
known
as
main
inhibitory
neurotransmitter
the
central
nervous
system.
Its
physiological
roles
are
related
to
modulation
of
synaptic
transmission,
promotion
neuronal
development
relaxation,
prevention
sleeplessness
depression.
Besides,
various
pharmaceutical
properties
on
non-neuronal
peripheral
tissues
organs
were
also
reported
due
anti-hypertension,
anti-diabetes,
anti-cancer,
antioxidant,
anti-inflammation,
anti-microbial,
anti-allergy,
hepato-protection,
reno-protection,
intestinal
protection.
Therefore,
may
be
considered
potential
alternative
therapeutics
for
treatment
diseases.
Accordingly,
this
updated
review
was
mainly
focused
describe
emphasize
its
important
role
regarding
human
health.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: July 15, 2024
The
gut
microbial
ecosystem
communicates
bidirectionally
with
the
brain
in
what
is
known
as
gut-microbiome-brain
axis.
Bidirectional
signaling
occurs
through
several
pathways
including
via
vagus
nerve,
circulation
of
metabolites,
and
immune
activation.
Alterations
microbiota
are
implicated
Alzheimer's
disease
(AD),
a
progressive
neurodegenerative
disease.
Perturbations
communities
may
affect
within
axis
altered
production
metabolites
ɣ-aminobutyric
acid
(GABA),
primary
inhibitory
mammalian
neurotransmitter.
GABA
has
been
shown
to
act
on
integrity
modulation
mucins
tight
junction
proteins
be
involved
nerve
signal
inhibition.
GABAergic
pathway
dysregulated
AD,
responsive
interventions.
Gut
recent
interest
neurological
disorders,
AD.
Bacteroides
Lactic
Acid
Bacteria
(LAB),
Lactobacillus,
predominant
producers
GABA.
This
review
highlights
how
temporal
alterations
associated
AD
pathway,
intestinal
barrier
integrity,
AD-associated
inflammation.
Food & Function,
Journal Year:
2019,
Volume and Issue:
10(7), P. 4315 - 4329
Published: Jan. 1, 2019
Caulerpa
lentilliferapolysaccharides
could
serve
as
novel
prebiotics
and
immunostimulators,
since
they
improve
the
immune-related
factors
modulate
gut
microbiota
in
cytoxan-induced
immunosuppressed
mice.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: Dec. 22, 2022
γ-aminobutyric
acid
(GABA)
is
a
non-protein
amino
which
naturally
and
widely
occurs
in
animals,
plants,
microorganisms.
As
the
chief
inhibitory
neurotransmitter
central
nervous
system
of
mammals,
it
has
become
popular
dietary
supplement
promising
application
food
industry.
The
current
article
reviews
most
recent
literature
regarding
physiological
functions,
preparation
methods,
enrichment
metabolic
pathways,
applications
GABA.
This
review
sheds
light
on
developing
GABA-enriched
plant
varieties
products,
provides
insights
for
efficient
production
GABA
through
synthetic
biology
approaches.
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: April 20, 2021
Abstract
Background
Sows
are
frequently
subjected
to
various
stresses
during
late
gestation
and
lactation,
which
trigger
inflammatory
response
metabolic
disorders.
Dietary
fiber
can
influence
animal
health
by
modulating
gut
microbiota
their
by-products,
with
the
effects
depending
upon
source
of
dietary
fiber.
This
study
aimed
evaluate
impacts
different
sources
on
body
condition,
serum
biochemical
parameters,
responses
fecal
in
sows
from
lactation.
Methods
Forty-five
multiparous
(Yorkshire
×
Landrace;
3–6
parity)
were
assigned
1
3
treatments
d
85
end
lactation
(d
21
post-farrowing):
a
control
diet
(CON,
corn-soybean
meal
diet),
sugar
beet
pulp
(SBP,
20%
SBP
10%
lactation),
wheat
bran
(WB,
30%
WB
15%
lactation).
Results
Compared
CON,
supplementation
decreased
(
P
<
0.05)
BW
loss,
reduced
concentration
total
cholesterol,
non-esterified
fatty
acids,
interleukin-6
tumor
necrosis
factor-α,
increased
water
content
110
while
cholesterol
gestation,
In
addition,
fed
had
lower
0.01)
abundance
Clostridium_sensu_stricto_1
Terrisporobacter
than
those
but
greater
Christensenellaceae_R-7_group
Ruminococcaceae_UCG-002
other
two
diets
gestation.
On
Firmicutes
Lactobacillus
,
enriched
Prevotellaceae_NK3B31_group
Prevotellaceae_UCG_001
unclassified_f__Lachnospiraceae
compared
WB.
concentrations
acetate,
butyrate
SCFAs
only
Conclusions
Supplementation
could
improve
sow
metabolism
health,
was
more
effective
Journal of Animal Science,
Journal Year:
2021,
Volume and Issue:
99(2)
Published: Feb. 1, 2021
Abstract
Essential
oils
are
plant-derived
aromatic
volatile
oils,
and
they
contain
bioactive
compounds
that
have
been
shown
to
improve
poultry
nutrition.
In
this
study,
we
investigated
the
effects
of
oregano
essential
oil
(OEO)
on
intestinal
antioxidative
capacity,
immunity,
gut
microbiota
young
yellow-feathered
chickens.
A
total
nine
hundred
sixty
1-d-old
female
Qingyuan
partridge
chickens
were
randomly
allocated
four
treatment
groups
with
six
replicates
40
birds
each,
feeding
trial
was
lasted
for
30
d.
The
controls
fed
a
basal
diet
without
in-feed
antibiotics;
in
antibiotic
group
supplemented
20
mg/kg
virginiamycin;
remaining
containing
150
or
300
OEO,
respectively.
Dietary
supplementation
OEO
increased
average
daily
feed
intake
(P
=
0.057)
gain
<
0.05).
activities
glutathione
peroxidase
capacity
plasma,
jejuna,
ileal
mucosa
by
0.05),
trend
lower
jejunal
content
malonaldehyde
0.062).
Moreover,
dietary
secretory
immunoglobulin
0.078)
relative
expression
Claudin
1,
Mucin
2,
Avain
beta-defensin
1
ileum
Sequencing
data
16S
rRNA
indicated
abundance
Firmicutes
phylum,
Clostridium
Lactobacillus
genera,
decreasing
Romboutsia.
Functional
analyses
microbial
amino
sugar
nucleotide
metabolism,
replication,
repair
systems
higher
than
those
treatment.
conclusion,
enhanced
growth
performance,
alleviated
local
oxidative
stress
intestine,
improved
production
natural
antibodies,
favorably
modulated
composition.
Animal nutrition,
Journal Year:
2023,
Volume and Issue:
13, P. 342 - 360
Published: April 6, 2023
In
swine
production,
stress
is
a
common
encounter
that
leads
to
serious
bacterial
infection
and
adverse
effects
on
growth
performance.
Though
antibiotics
have
been
frequently
used
control
pathogen
spread,
sustained
negative
impacts
from
found
affect
intestinal
integrity
the
immune
system.
Multiple
nutritional
strategies
shown
potential
counteract
replace
antibiotics,
including
functional
amino
acids,
low
protein
diet,
plant
extracts,
organic
prebiotics,
probiotics,
minerals
vitamins.
These
additives
relieve
response
in
via
different
mechanisms
signal
transduction
pathways.
Based
overview
of
signaling
pathways
models,
this
review
highlights
for
preventing
or
treating
stress-related
health
problems.
For
wider
application
pig
industry,
dose
ranges
measured
require
further
validation
physiological
contexts
formulations.
future,
microfluid
devices
novel
models
are
expected
enhance
efficiency
screening
new
anti-stress
candidates.
Journal of Animal Science,
Journal Year:
2020,
Volume and Issue:
98(5)
Published: April 7, 2020
Antibiotics
are
commonly
overused
to
reduce
weaning
stress
that
leads
economic
loss
in
swine
production.
As
potential
substitutes
of
antibiotics,
plant
extracts
have
attracted
the
attention
researchers.
However,
one
extracts,
tannic
acid
(TA),
has
an
adverse
effect
on
growth
performance,
palatability,
and
intestinal
absorption
piglets
when
used
at
a
large
amount.
Thus,
this
study
aimed
investigate
effects
proper
dose
microencapsulated
TA
organ
development,
morphology,
nutrient
transporters,
colonic
microbiota
piglets.
Forty-five
Duroc
×
[Landrace
Yorkshire]
(initial
body
weight
=
5.99
±
0.13
kg,
weaned
days
21
d)
were
randomly
divided
into
five
treatment
groups
(n
9)
raised
14
d.
The
control
group
basal
diet;
antibiotic
test
diet
with
three
antibiotics
(375
mg/kg
Chlortetracycline
20%,
500
Enramycin
4%,
1,500
Oxytetracycline
calcium
20%);
other
doses
(TA1,
mg/kg;
TA2,
1,000
TA3,
mg/kg).
All
same
environment
given
amount
nutrients
for
2
wk.
results
showed
both
TA1
TA2
had
no
growth,
pH
value
gastrointestinal
content.
improved
duodenal
morphology
(P
<
0.05),
increased
gene
expression
level
solute
carrier
family
6,
member
19
15,
1
0.05)
ileum,
modulated
bacteria
composition
but
inhibited
activity
maltase
ileum
jejunal
5,
0.05).
In
conclusion,
our
suggests
dosage
between
is
safe
be
included
beneficial
transporter,
These
findings
provide
new
insights
suitable
alternatives
improving
performance
microbiota.
