Chemical Communications,
Journal Year:
2020,
Volume and Issue:
56(29), P. 4078 - 4081
Published: Jan. 1, 2020
A
novel
method
for
the
synthesis
of
3-(2-quinolyl)
chromones
through
a
tandem
[3+2]
cycloaddition/ring-opening/O-arylation
from
ynones
and
quinoline
N-oxides
has
been
developed.
This
protocol
proceeds
under
transition
metal-
additive-free
conditions
can
be
amplified
to
gram
level
in
91%
yield.
3-(1-Isoquinolyl)
3-(2-pyridyl)
are
also
successfully
synthesized
using
isoquinoline
pyridine
basic
conditions.
Various
heteroarene-contaning
were
afforded
30-98%
yields,
which
difficult
obtained
compounds
interest
pharmaceutical
chemistry
chemical
biology.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(22), P. 4471 - 4495
Published: Jan. 1, 2022
This
review
mainly
focuses
on
the
research
progress
achieved
in
synthesis
of
methylthiolated
products
using
cheap
and
environmentally
friendly
DMSO
as
an
SMe
source.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
41(23), P. 3388 - 3400
Published: June 24, 2023
Comprehensive
Summary
This
review
provides
a
comprehensive
summary
of
progress
to
date
in
the
utilization
rongalite
as
versatile
reagent
organic
synthesis,
with
focus
on
recent
researches.
The
contents
have
been
organized
according
functions
exhibited
by
rongalite.
Reaction
mechanisms
are
provided,
demonstrating
multifaceted
roles
this
compound
various
transformations,
including
sulfone,
C1
or
masked
proton
source
and
single
electron
donor
reducing
agent.
Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Nov. 26, 2022
Abstract
In
multicomponent
reactions,
three
or
more
reactants
combine
in
one
pot
to
form
a
product
without
the
isolation
of
intermediate
and
most
contribute
newly
formed
reducing
number
steps
involved
waste
generated.
Molecular
iodine
is
mild,
efficient,
relatively
nontoxic,
inexpensive,
commercially
available,
catalyzes
various
organic
reactions
due
its
Lewis
acidic
behaviour.
The
development
catalyzed
by
molecular
indeed
good
green
alternative
for
synthetic
chemistry.
aim
this
article
review
all
important
reported
since
2013
order
envisage
some
new
efficient
protocols
synthesis
structurally
complex
molecules.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(8), P. 1727 - 1732
Published: Jan. 1, 2024
In
this
study,
we
developed
a
novel
methodology
involving
base-controlled,
rongalite-mediated
reductive/aldol
reaction,
followed
by
cyclization
of
isatylidene
malononitriles/cyanoacetates,
resulting
in
the
synthesis
spiro[2,3-dihydrofuran-3,3'-oxindole].
Additionally,
have
disclosed
dimerization
process
for
malononitriles,
yielding
dispiro[cyclopent-3'-ene]bisoxindole.
The
utilization
rongalite
reaction
serves
dual
purpose,
acting
both
as
reducing
agent
and
C1
synthon.
approach
has
several
advantages
like
simple
setup,
wide
substrate
scope,
requiring
less
time,
using
water
green
solvent,
no
metal
or
catalyst
is
required
products
can
be
easily
isolated
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(11), P. 8220 - 8229
Published: May 16, 2024
In
this
work,
a
practical
copper-catalyzed
multicomponent
coupling
reaction
of
primary
aromatic
amines,
rongalite,
and
alkynes
for
the
direct
synthesis
N-aryl
propargylamines
has
been
developed.
This
method
could
overcome
substrate
limitation
in
A3
reactions
formaldehyde,
alkynes.
Mechanistic
studies
revealed
that
rongalite
acts
as
not
only
active
C1
unit
but
also
accelerator
to
activate
situ-generated
N-arylmethanimines
with
is
highly
efficient
features
broad
scope,
well
utility
scale-up
converting
corresponding
product
into
useful
heterocyclic
skeletons.
Organic Letters,
Journal Year:
2019,
Volume and Issue:
21(10), P. 3658 - 3662
Published: April 26, 2019
An
efficient
and
facile
method
to
synthesize
valuable
disubstituted
2-aryl
indoles
benzofurans
in
good
yields
has
been
demonstrated,
based
on
a
tert-butoxide-mediated
condensation
reaction
involving
vinyl
sulfoxide
intermediate.
Products
are
obtained
from
N-
or
O-benzyl
benzaldehydes
using
dimethyl
as
carbon
source.
The
methodology
features
wide
functional
group
tolerance
transition
metal-free
environment.
Preliminary
mechanistic
studies
suggest
that
the
involves
tandem
aldol
reaction/Michael
addition/dehydrosulfenylation/isomerization
sequence
through
an
ionic
protocol.
ChemistrySelect,
Journal Year:
2020,
Volume and Issue:
5(34), P. 10795 - 10815
Published: Sept. 10, 2020
Abstract
Rongalite,
first
time
reported
in
the
chemical
structure
1905,
also
known
as
bruggolite
or
sodium
formaldehyde
sulfoxylate,
having
good
solubility
and
stability
organic
media,
is
not
only
a
cheap
commercially
available
(in
kg
amount)
reagent
with
range
of
industrial
applications
for
instance
emulsion
polymerization,
an
excellent
decolouring
agent,
antioxidant
pharmaceutical
development,
antidote
heavy
metals,
but
used
effective
regents
plethora
reactions
particularly
redox
powerful
reducing
agent.
More
interestingly,
recent
years,
it
has
shown
its
impact
material
sciences
preparation
CdTe,
CoTe
2
,
Ag
Se
thin
films,
nanowire
networks,
hollow
nanospheres,
copper
nanoparticles
(Cu‐Nps),
CdTe‐quantum
dots
so
forth.
Keeping
mind
importance
this
vital
both
chemistry
well
sciences,
herein
I
intended
to
report
developments
along
brief
overview
old
literature
wherever
necessary
showcase
utility
valuable
reagent.
This
particular
review
article
covers
environmentaly
benign
synthesis
usefulness
nanosciences
been
exposed
time.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(24), P. 4926 - 4932
Published: Jan. 1, 2022
Rongalite
induced
transition
metal
and
hydride-free
reductive
aldol
reaction
is
developed
for
3-methylindoline-2-ones
3-(hydroxymethyl)-3-methylindolin-2-ones
from
2-oxindoles.
Here,
plays
a
key
role
of
being
reductant
C1
source.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(41), P. 7659 - 7664
Published: Oct. 10, 2022
An
unprecedented
[1+1+1+1+1+1]
annulation
process
has
been
developed
for
the
construction
of
tetrahydro-2H-thiopyran
1,1-dioxides.
Notably,
rongalite
acted
as
a
tethered
C-S
synthon
in
this
reaction
and
can
be
chemoselectively
used
triple
C1
units
source
sulfone.
Mechanistic
investigation
indicated
that
two
different
carbon-increasing
models
are
involved
which
serves
units.
