Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)

Published: Dec. 2, 2021

Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.

Language: Английский

---

Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

Bioactive Materials, Journal Year: 2021, Volume and Issue: 8, P. 267 - 295

Published: July 6, 2021

Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-based have been devoted to combining them with bioactive functional nanomaterials, aiming provide enhanced physicochemical biological properties GelMA. The benefits this approach multiple: i) reinforcing mechanical properties, ii) modulating viscoelastic property allow printability bio-inks, iii) rendering electrical/magnetic produce electro-/magneto-active the specific tissues (e.g., muscle, nerve), iv) providing stimuli-responsiveness actively deliver molecules, v) endowing capacity in process antioxidant effects). nanomaterial-combined GelMA shown significantly extraordinary behaviors (bone, skin, cardiac, nerve) that rarely observable Here we systematically review these recent nanomaterials-combined considered next-generation multifunctional therapeutics. approaches used can also apply other existing polymeric systems.

Language: Английский

---

Biogenic nanoparticles: a comprehensive perspective in synthesis, characterization, application and its challenges

Journal of Genetic Engineering and Biotechnology, Journal Year: 2020, Volume and Issue: 18(1), P. 67 - 67

Published: Oct. 26, 2020

Translating the conventional scientific concepts into a new robust invention is much needed one at present scenario to develop some novel materials with intriguing properties. Particles in nanoscale exhibit superior activity than their bulk counterpart. This unique feature intensively utilized physical, chemical, and biological sectors. Each metal holding optical properties that can be synthesize metallic nanoparticles. At present, versatile nanoparticles were synthesized through chemical methods. Metallic pose numerous merits have promising industrial applications. But concerning pros cons of nanoparticle synthesis methods, researchers elevate drive process utilization plant resources as substitute for use chemicals reagents under theme green chemistry. These antimicrobial, anticancer, larvicidal, leishmaniasis, wound healing, antioxidant, sensor. Therefore, such conceptualized treating infectious environmental applications warranted one. Green chemistry keen prudence method, which bioresources used template this review, we exclusively update context plant-based synthesis, characterization, detailed coverage. Hopefully, our review will modernizing recent trends going on blooming research fraternities.

Language: Английский

---

Advanced bioactive nanomaterials for biomedical applications

Exploration, Journal Year: 2021, Volume and Issue: 1(3)

Published: Dec. 1, 2021

Bioactive materials are a kind of with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. came into spotlight in late 1960s when researchers found that such as bioglass could react surrounding bone tissue for regeneration. In following decades, advances nanotechnology brought new development opportunities to bioactive nanomaterials. nanomaterials not simple miniaturization macroscopic materials. They exhibit bioactivities due their nanoscale size effect, high specific surface area, precise nanostructure, significantly influence interactions systems. Nowadays, have represented an important exciting area research. Current future applications ensure academic clinical importance. This review summaries recent field nanomaterials, evaluate factors bioactivities. Then, range potential biomedical discussed. Furthermore, limitations, challenges, also

Language: Английский

---

Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Language: Английский

---

ZnO nanomaterials: Green synthesis, toxicity evaluation and new insights in biomedical applications

Journal of Alloys and Compounds, Journal Year: 2021, Volume and Issue: 876, P. 160175 - 160175

Published: May 4, 2021

Language: Английский

---

Preparation and characterization of chitosan/pectin/ZnO porous films for wound healing

International Journal of Biological Macromolecules, Journal Year: 2020, Volume and Issue: 157, P. 135 - 145

Published: April 24, 2020

Language: Английский

---

Recent Advance in Biological Responsive Nanomaterials for Biosensing and Molecular Imaging Application

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1923 - 1923

Published: Feb. 8, 2022

In recent decades, as a subclass of biomaterials, biologically sensitive nanoparticles have attracted increased scientific interest. Many the demands for physiologically responsive nanomaterials in applications involving human body cannot be met by conventional technologies. Due to field’s importance, considerable effort has been expended, and achieved remarkable success thus far. This review summarizes advancements their biosensing molecular imaging. The change structure or increase chemical reaction ratio response specific bio-relevant stimuli (such pH, redox potentials, enzyme kinds, concentrations) order improve signal diagnosis. We use various case studies illustrate existing issues provide clear sense direction this area. Furthermore, limitations prospects these diagnosis are also discussed.

Language: Английский

---

Biopolymer and Synthetic Polymer-Based Nanocomposites in Wound Dressing Applications: A Review

Polymers, Journal Year: 2021, Volume and Issue: 13(12), P. 1962 - 1962

Published: June 13, 2021

Biopolymers are materials obtained from a natural origin, such as plants, animals, microorganisms, or other living beings; they flexible, elastic, fibrous materials. Polysaccharides and proteins some of the polymers that widely used in wound dressing applications. In this review paper, we will provide an overview biopolymers synthetic polymer-based nanocomposites, which have promising applications biomedical research field, dressings, healing, tissue engineering, drug delivery, medical implants. Since these intrinsic biocompatibility, low immunogenicity, non-toxicity, biodegradable properties, can be for various clinical The significant advancements research, development, nanotechnology, biotechnology laid foundation changing biopolymeric structural functional properties. properties biopolymer were modified by blending them with nanoparticles, so application. Recent care issues, repairs, scarless lost integrity, treated blended polymers. Currently, researchers focusing on metal/metal oxide nanomaterials zinc (ZnO), cerium (CeO2), silver (Ag), titanium (TiO2), iron (Fe2O3), (graphene carbon nanotubes (CNT)). These good antimicrobial well action antibacterial agents. Due to highly materials,

Language: Английский

---

Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 337, P. 236 - 247

Published: July 14, 2021

Language: Английский

---