Progress in Hydrogels for Skin Wound Repair

Macromolecular Bioscience, Journal Year: 2022, Volume and Issue: 22(7)

Published: April 7, 2022

Abstract As the first defensive line between human body and outside world, skin is vulnerable to damage from external environment. Skin wounds can be divided into acute (mechanical injuries, chemical surgical wounds, etc.) chronic (burns, infections, diabetes, etc.). In order manage wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, hydrogels. Recently, hydrogels received much attention because their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, facile bioactive substance delivery capability. They show great potential application in repair. This paper introduces anatomy function skin, process healing conventional dressings, then composition construction methods Next, this necessary properties repair latest research progress hydrogel for Finally, future development goals materials field are proposed.

Language: Английский

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Green Synthesis of Metal and Metal Oxide Nanoparticles: A Review of the Principles and Biomedical Applications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15397 - 15397

Published: Oct. 20, 2023

In recent years, interest in nanotechnology has increased exponentially due to enhanced progress and technological innovation. tissue engineering, the development of metallic nanoparticles been amplified, especially their antibacterial properties. Another important characteristic metal NPs is that they enable high control over features developed scaffolds (optimizing mechanical strength offering controlled release bioactive agents). Currently, main concern related method synthesis oxide environmental impact. The physical chemical uses toxic agents could generate hazards or exert carcinogenicity/environmental toxicity. Therefore, a greener, cleaner, more reliable approach needed. Green synthetic come as solution counter aforementioned limitations. Nowadays, green preferred because it leads prevention/minimization waste, reduction derivatives/pollution, use non-toxic (safer) solvents. This not only biomass sources reducing for salts. biomolecules also cover synthesized act situ capping agents. Further, involvement formation process reduces toxicity, prevents nanoparticle agglomeration, improves antimicrobial activity nanomaterial, leading possible synergistic effect. study aims provide comprehensive review nanoparticles, from routes, selected solvents, parameters latest application biomedical field.

Language: Английский

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Influence of the Alcohols on the ZnO Synthesis and Its Properties: The Photocatalytic and Antimicrobial Activities

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2842 - 2842

Published: Dec. 18, 2022

Zinc oxide (ZnO) nanomaterials are used in various health-related applications, from antimicrobial textiles to wound dressing composites and sunscreens packaging. Purity, surface defects, size, morphology of the nanoparticles main factors that influence properties. In this study, we comparing properties ZnO obtained by solvolysis using a series alcohols: primary methanol 1-hexanol, secondary (2-propanol 2-butanol), tertiary (tert-butanol). While synthesis is successfully accomplished all alcohols, use or alcohols does not lead as final product, underlining importance solvent. The shape depends on alcohol used, quasi-spherical rods, consequently, different reported, including photocatalytic activities. 1-butanol exhibited best performance against methylene blue (MB) dye solution, attaining degradation efficiency 98.24%. comparative study among usual model dyes revealed triarylmethane less susceptible photo-degradation. present strong activity broad range microorganisms (bacterial fungal strains), size being important factors. This permits further tailoring for medical applications.

Language: Английский

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Surface modification of TiO₂nanoparticles with organic molecules and their biological applications

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(11), P. 2334 - 2366

Published: Jan. 1, 2023

In recent years, titanium( iv ) dioxide nanoparticles (TiO 2 NPs) have shown promising potential in various biological applications such as antimicrobials, drug delivery, photodynamic therapy, biosensors, and tissue engineering.

Language: Английский

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Recent progress in polymeric biomaterials and their potential applications in skin regeneration and wound care management

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104319 - 104319

Published: Feb. 27, 2023

Language: Английский

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Hydrogel-Based Skin Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1982 - 1982

Published: Feb. 6, 2024

The skin is subject to damage from the surrounding environment. repair of wounds can be very challenging due several factors such as severe injuries, concomitant infections, or comorbidities diabetes. Different drugs and wound dressings have been used treat wounds. Tissue engineering, a novel therapeutic approach, revolutionized treatment regeneration tissue damage. This field includes use synthetic natural biomaterials that support growth tissues organs outside body. Accordingly, demand for polymer-based strategies defects significantly increasing. Among various 3D scaffolds in hydrogel gained special significance their unique properties mimicry extracellular matrix (ECM), moisture retention, porosity, biocompatibility, biodegradability, biocompatibility properties. First, this article delineates process healing conventional methods treating It then presents an examination structure manufacturing hydrogels, followed by analysis crucial characteristics most recent advancements using purpose. Finally, it discusses potential future materials within realm healing.

Language: Английский

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Engineered Bio‐Based Hydrogels for Cancer Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 16, 2024

Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.

Language: Английский

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Recent advances of electrospray technique for multiparticulate preparation: Drug delivery applications

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 325, P. 103098 - 103098

Published: Feb. 4, 2024

Language: Английский

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Grafting modification for textile functionalization: innovations and applications

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 3, 2025

The functionalization of textiles through grafting modification has emerged as a promising approach, offering bright future for the textile industry. This process involves covalent attachment functional polymers to substrates, imparting desirable properties such hydrophobicity, antimicrobial activity, UV resistance, drug delivery capabilities, flame and improved dyeability. Various techniques, including chemical, plasma-induced, radiation-induced grafting, have been explored achieve these modifications. review highlights advancements in methods, selecting suitable agents, resulting conferred on textiles. discussion also addresses environmental economic aspects modification, emphasizing sustainable practices applications. integration into manufacturing processes offers significant opportunities developing high-performance with tailored functionalities, meeting evolving demands consumers industries. constant evolution adaptation meet keeps our industry vibrant engaging.

Language: Английский

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A Mechanistic Overview on Green Assisted Formulation of Nanocomposites and Their Multifunctional Role in Biomedical Applications

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41654 - e41654

Published: Jan. 8, 2025

The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.

Language: Английский

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