ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(42), P. 37050 - 37060
Published: Oct. 14, 2022
An
efficient
synthesis
of
a
variety
1,2-disubstituted-5,6-dihydropyrrolo[2,1-α]isoquinoline
derivatives
via
an
acid-promoted
cyclization
reaction
between
1,2,3,4-tetrahydroisoquinoline
(THIQ)
and
substituted
α,β-unsaturated
aldehyde
is
reported.
This
cycloaddition
allows
access
to
structurally
diverse
multisubstituted
dihydropyrrolo[2,1-α]isoquinolines
in
moderate
good
yields,
which
was
the
core
scaffold
marine
natural
alkaloid
lamellarins.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(3), P. 995 - 999
Published: Jan. 27, 2021
In
this
work,
ruthenium(II)-catalyzed
C–C/C–N
annulation
of
2-arylquinazolinones
with
vinylene
carbonate
is
reported
to
synthesize
fused
quinazolinones.
This
catalytic
system
tolerates
a
wide
range
substrates
excellent
functional-group
compatibility.
transformation,
the
acts
as
an
ethynol
surrogate
without
any
external
oxidant
involved.
Furthermore,
preliminary
mechanistic
studies
were
conducted,
and
plausible
cycle
was
also
proposed.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(7), P. 4199 - 4208
Published: Jan. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Organic Chemistry Frontiers,
Journal Year:
2020,
Volume and Issue:
7(9), P. 1177 - 1196
Published: Jan. 1, 2020
This
review
article
provides
an
overview
of
the
recent
progress
in
transformations
anthranils,
which
have
emerged
as
versatile
building
blocks
assembly
various
C–N
bonds
and
medicinally
active
heterocyclic
systems.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(32), P. 6293 - 6313
Published: Jan. 1, 2022
As
one
of
the
most
important
structural
units
in
pharmaceuticals
and
medicinal
chemistry,
quinazolinone
its
derivatives
exhibit
a
wide
range
biological
pharmacological
activities,
including
anti-inflammatory,
antitubercular,
antiviral,
anticancer
etc.
In
particular,
2,3-fused
quinazolinones
have
attracted
much
attention
because
rings
fused
to
2,3-positions
improve
their
rigidity
planarity.
Their
synthetic
strategies
made
great
advances
recent
years.
Therefore,
this
review
focuses
on
novel
for
synthesis
from
2017
2022,
such
as
difunctionalization
alkenes,
ring-opening
easily
available
small
rings,
dehydrogenative
cross-coupling
reactions,
transition-metal
catalyzed
cyclizations,
cycloadditions,
other
cascade
reactions.
Organic Chemistry Frontiers,
Journal Year:
2020,
Volume and Issue:
7(13), P. 1635 - 1639
Published: Jan. 1, 2020
An
efficient
TFA/TBHP-promoted
oxidative
cyclisation
of
readily
available
isatins
with
1,2,3,4-tetrahydroisoquinolines
has
been
firstly
developed.
The
potential
utility
this
strategy
was
demonstrated
by
one-step
synthesis
a
natural
alkaloid
Rutaecarpin.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(6), P. 1348 - 1355
Published: Jan. 13, 2024
Abstract
A
total
synthesis
strategy
was
developed
for
the
of
luotonin
A,
B
and
their
analogues
using
synergistic
FeCl
3
/KI‐catalyzed
oxidative
cyclization.
This
protocol
utilizes
cheap
widely
available
N
‐propargyl
2‐methyl‐quinazolinones
arylamines
under
mild
conditions,
it
has
a
wide
substrate
scope
high
atom
economy.
Different
natural
products
(luotonin
derivatives)
can
be
synthesized
via
unique
switchable
approach.
Further
transformations
from
to
E
structural
modification
demonstrate
potential
applications
this
method.
Moreover,
camptothecin
also
modified
with
reported
afford
hydroxyl‐substituted
product.
Organometallics,
Journal Year:
2023,
Volume and Issue:
42(3), P. 211 - 217
Published: Jan. 3, 2023
Many
methods
report
the
scission
of
N–O
bonds
aromatic
heterocycles
and
their
subsequent
functionalization.
Oxidative
addition
is
one
presumed
pathways
through
which
bond
activation
with
transition
metals
achieved.
We
first
well-defined
pathway
(benz)isoxazole's
oxidative
addition.
also
provide
control
experiments,
show
that
may
be
broken
by
strong
inorganic
reductants.
These
results
highlight
are
susceptible
to
both
reduction
addition,
has
important
implications
for
catalysis.
Exploring
reactivity
these
complexes
toward
a
series
electrophiles
leads
discovery
Staudinger-type
β-lactam
synthesis
upon
reaction
ketene.
Finally,
we
demonstrate
choice
different
metal/ligand
combinations
allows
selective
into
either
C–I
or
in
presence
other.
Chinese Journal of Chemistry,
Journal Year:
2020,
Volume and Issue:
38(11), P. 1239 - 1244
Published: May 17, 2020
Summary
of
main
observation
and
conclusion
Polycyclic
fused
quinazolinones
with
anti‐malarial
activity
were
synthesized
through
tert
‐butyl
hydroperoxide
(TBHP)‐mediated
oxidative
decarboxylative
cyclization
between
commercially
available
isatins
cyclic
amines
in
one
step.
The
reaction
proceeds
smoothly
water
without
additional
transition‐metal
catalyst,
acid
base.
newly
products
evaluated
to
exhibit
moderate
good
against
chloroquine
drug‐sensitive
Plasmodium
falciparum
3D7
strain.
Additionally,
this
method
also
provides
direct
approach
Rutaecarpine
yield.
Chinese Journal of Chemistry,
Journal Year:
2020,
Volume and Issue:
39(1), P. 87 - 92
Published: Aug. 4, 2020
A
copper‐catalyzed
aerobic
oxidative
ring
expansion
reaction
of
isatins
with
1,2,3,4‐tetrahydroisoquinoline
for
the
synthesis
tetracyclic
quinazolinones
has
been
developed.
This
is
performed
smoothly
under
simple
conditions
to
give
corresponding
products
in
moderate
good
yields
functional
group
tolerance.
The
capacity
resultant
5
H
‐isoquinolino[1,2‐
b
]quinazolin‐8(6
)‐one
a
range
palladium‐catalyzed
directing
C—H
activation
further
demonstrated,
thus
giving
broader
access
diverse
quinazolinones.
