Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(49)
Published: Oct. 1, 2021
Bioprinting,
within
the
emerging
field
of
biofabrication,
aims
at
fabrication
functional
biomimetic
constructs.
Different
3D
bioprinting
techniques
have
been
adapted
to
bioprint
cell-laden
bioinks.
However,
single-material
oftentimes
fail
reproduce
complex
compositions
and
diversity
native
tissues.
Multi-material
as
an
approach
enables
heterogeneous
multi-cellular
constructs
that
replicate
their
host
microenvironments
better
than
approaches.
Here,
modalities
are
reviewed,
being
multi-material
is
discussed,
advantages
challenges,
encompassing
both
custom-designed
commercially
available
technologies
analyzed.
A
perspective
how
opens
up
new
opportunities
for
tissue
engineering,
model
therapeutics
development,
personalized
medicine
offered.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(8), P. 4309 - 4372
Published: April 12, 2021
Hydrogels
are
polymer
networks
infiltrated
with
water.
Many
biological
hydrogels
in
animal
bodies
such
as
muscles,
heart
valves,
cartilages,
and
tendons
possess
extreme
mechanical
properties
including
being
extremely
tough,
strong,
resilient,
adhesive,
fatigue-resistant.
These
also
critical
for
hydrogels'
diverse
applications
ranging
from
drug
delivery,
tissue
engineering,
medical
implants,
wound
dressings,
contact
lenses
to
sensors,
actuators,
electronic
devices,
optical
batteries,
water
harvesters,
soft
robots.
Whereas
numerous
have
been
developed
over
the
last
few
decades,
a
set
of
general
principles
that
can
rationally
guide
design
using
different
materials
fabrication
methods
various
remain
central
need
field
materials.
This
review
is
aimed
at
synergistically
reporting:
(i)
achieve
physical
properties,
(ii)
implementation
strategies
unconventional
networks,
(iii)
future
directions
orthogonal
multiple
combined
mechanical,
physical,
chemical,
properties.
Because
these
based
on
generic
they
applicable
other
elastomers
organogels.
Overall,
will
not
only
provide
comprehensive
systematic
guidelines
rational
materials,
but
provoke
interdisciplinary
discussions
fundamental
question:
why
does
nature
select
constitute
major
parts
bodies?
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(17)
Published: Feb. 28, 2020
Abstract
Developing
physical
double‐network
(DN)
removable
hydrogel
adhesives
with
both
high
healing
efficiency
and
photothermal
antibacterial
activities
to
cope
multidrug‐resistant
bacterial
infection,
wound
closure,
remains
an
ongoing
challenge.
An
injectable
DN
self‐healing
adhesive
under
physiological
conditions
is
designed
treat
bacteria
infection
full‐thickness
skin
incision/defect
repair.
The
consists
of
catechol–Fe
3+
coordination
cross‐linked
poly(glycerol
sebacate)‐
co
‐poly(ethylene
glycol)‐
g
‐catechol
quadruple
hydrogen
bonding
ureido‐pyrimidinone
modified
gelatin.
It
possesses
excellent
anti‐oxidation,
NIR/pH
responsiveness,
shape
adaptation.
Additionally,
the
presents
rapid
self‐healing,
good
tissue
adhesion,
degradability,
activity,
NIR
irradiation
and/or
acidic
solution
washing‐assisted
removability.
In
vivo
experiments
prove
that
hydrogels
have
hemostasis
trauma
killing
ratio
for
methicillin‐resistant
staphylococcus
aureus
(MRSA)
achieve
better
closure
incision
than
medical
glue
surgical
suture.
particular,
they
can
significantly
promote
defect
by
regulating
inflammation,
accelerating
collagen
deposition,
promoting
granulation
formation,
vascularization.
These
on‐demand
dissolvable
antioxidant
are
multifunctional
dressings
treating
in
MRSA
healing.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(11), P. 3605 - 3637
Published: Jan. 1, 2020
This
review
presents
the
recent
progress
of
mussel-inspired
hydrogels
from
fundamental
interaction
mechanisms
and
design
principles
to
promising
applications.
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
8, P. 341 - 354
Published: June 23, 2021
With
the
increasing
prevalence
of
drug-resistant
bacterial
infections
and
slow
healing
chronically
infected
wounds,
development
new
antibacterial
accelerated
wound
dressings
has
become
a
serious
challenge.
In
order
to
solve
this
problem,
we
developed
photo-crosslinked
multifunctional
adhesive
anti-oxidant
hemostatic
hydrogel
based
on
polyethylene
glycol
monomethyl
ether
modified
glycidyl
methacrylate
functionalized
chitosan
(CSG-PEG),
methacrylamide
dopamine
(DMA)
zinc
ion
for
disinfection
bacteria
promoting
healing.
The
mechanical
properties,
rheological
properties
morphology
hydrogels
were
characterized,
biocompatibility
these
was
studied
through
cell
compatibility
blood
tests.
These
tested
in
vitro
blood-clotting
ability
whole
showed
good
mouse
liver
hemorrhage
model
mouse-tail
amputation
model.
addition,
it
been
confirmed
that
have
inherent
against
Methicillin-resistant
Staphylococcus
aureus
(MRSA).
full-thickness
skin
defect
with
MRSA,
closure
ratio,
thickness
granulation
tissue,
number
collagen
deposition,
regeneration
vessels
hair
follicles
measured.
inflammation-related
cytokines
(CD68)
angiogenesis-related
(CD31)
expressed
during
studied.
All
results
indicate
better
effects
than
commercially
available
Tegaderm™
Film,
revealing
they
promising
alternative
wounds.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5604 - 5640
Published: Jan. 13, 2022
Tissue
engineering
is
a
promising
and
revolutionary
strategy
to
treat
patients
who
suffer
the
loss
or
failure
of
an
organ
tissue,
with
aim
restore
dysfunctional
tissues
enhance
life
expectancy.
Supramolecular
adhesive
hydrogels
are
emerging
as
appealing
materials
for
tissue
applications
owing
their
favorable
attributes
such
tailorable
structure,
inherent
flexibility,
excellent
biocompatibility,
near-physiological
environment,
dynamic
mechanical
strength,
particularly
attractive
self-adhesiveness.
In
this
review,
key
design
principles
various
supramolecular
strategies
construct
comprehensively
summarized.
Thereafter,
recent
research
progress
regarding
applications,
including
primarily
dermal
repair,
muscle
bone
neural
vascular
oral
corneal
cardiac
fetal
membrane
hepatic
gastric
systematically
highlighted.
Finally,
scientific
challenges
remaining
opportunities
underlined
show
full
picture
hydrogels.
This
review
expected
offer
comparative
views
critical
insights
inspire
more
advanced
studies
on
pave
way
different
fields
even
beyond
applications.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(25)
Published: April 20, 2020
Abstract
Wearable
and
implantable
bioelectronics
are
receiving
a
great
deal
of
attention
because
they
offer
huge
promise
in
personalized
healthcare.
Currently
available
generally
rely
on
external
aids
to
form
an
attachment
the
human
body,
which
leads
unstable
performance
practical
applications.
Self‐adhesive
highly
desirable
for
ameliorating
these
concerns
by
offering
reliable
conformal
contact
with
tissue,
stability
fidelity
signal
detection.
However,
achieving
adequate
long‐term
self‐adhesion
soft
wet
biological
tissues
has
been
daunting
challenge.
Recently,
mussel‐inspired
hydrogels
have
emerged
as
promising
candidates
design
self‐adhesive
bioelectronics.
In
addition
self‐adhesiveness,
chemistry
offers
unique
pathway
integrating
multiple
functional
properties
all‐in‐one
bioelectronic
devices,
implications
healthcare
this
report,
recent
progress
area
is
highlighted
specifically
discussing:
1)
adhesion
mechanism
mussels,
2)
repeatable
adhesion,
3)
advance
development
hydrogel
reconciling
self‐adhesiveness
additional
including
conductivity,
toughness,
transparency,
self‐healing,
antibacterial
properties,
tolerance
extreme
environment,
4)
challenges
prospects
future
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(14), P. 8319 - 8343
Published: Jan. 1, 2021
This
review
provides
in-depth
insight
into
the
structural
engineering
of
PDA-based
materials
to
enhance
their
responsive
feature
and
use
them
in
construction
stimuli-responsive
smart
materials.
Materials Horizons,
Journal Year:
2020,
Volume and Issue:
7(7), P. 1872 - 1882
Published: Jan. 1, 2020
Stretchable,
self-healing,
and
fatigue
resistant
polyzwitterionic
nanocomposite
hydrogels
with
polydopamine
robustly
adhere
to
the
heart
lungs
for
in
situ
monitoring
of
dynamic
motions
through
wireless
transmission.
Materials Horizons,
Journal Year:
2020,
Volume and Issue:
8(1), P. 145 - 167
Published: Sept. 17, 2020
Polyphenols
are
a
class
of
ubiquitous
compounds
distributed
in
nature,
with
fascinating
inherent
biocompatible,
bioadhesive,
antioxidant,
and
antibacterial
properties.
The
unique
polyphenolic
structures
based
on
catechol
or
pyrogallol
moieties
allow
for
strong
non-covalent
interactions
(e.g.,
multiple
hydrogen
bonding,
electrostatic,
cation-π
interactions)
as
well
covalent
Michael
addition/Schiff-base
reaction,
radical
coupling
dynamic
coordination
boronate
metal
ions).
This
review
article
provides
an
overview
the
polyphenol-based
scaffolds
including
hydrogels,
films,
nanofibers
that
have
emerged
from
chemical
functional
signatures
during
past
years.
A
full
description
structure-function
relationships
terms
their
utilization
wound
healing,
bone
regeneration,
electroactive
tissue
engineering
is
also
carefully
discussed,
which
may
pave
path
towards
rational
design
facile
preparation
next-generation
polyphenol
applications.
