Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5604 - 5640

Published: Jan. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Language: Английский

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Bioinspired Underwater Adhesives

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(44)

Published: Sept. 17, 2021

Abstract Underwater adhesives are in high demand both commercial and industrial sectors. Compared with used dry (air) environments, for wet or submerged surfaces aqueous environments have specific challenges development performance. In this review, focus is on demonstrating macroscopic adhesion to wet/underwater substrates. The current strategies first introduced different types of underwater adhesives, then an overview provided the performance based mechanisms strategies. Finally, possible research directions prospects discussed.

Language: Английский

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Metal Ion-Directed Functional Metal–Phenolic Materials

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(13), P. 11432 - 11473

Published: May 10, 2022

Metal ions are ubiquitous in nature and play significant roles assembling functional materials fields spanning chemistry, biology, science. Metal-phenolic assembled from phenolic components the presence of metal through formation metal-organic complexes. Alkali, alkali-earth, transition, noble as well metalloids interacting with building blocks have been widely exploited to generate diverse hybrid materials. Despite extensive studies on synthesis metal-phenolic materials, a comprehensive summary how guide assembly compounds is lacking. A fundamental understanding engineering will facilitate specific properties. In this review, we focus diversity function material emerging applications. Specifically, discuss range underlying interactions, including (i) cation-π, (ii) coordination, (iii) redox, (iv) dynamic covalent highlight wide properties resulting these interactions. Applications (e.g., biological, catalytic, environmental) perspectives also highlighted.

Language: Английский

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Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing

Bioactive Materials, Journal Year: 2023, Volume and Issue: 30, P. 129 - 141

Published: July 28, 2023

In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. this study, series adhesive conductive antibacterial hydrogel based on oxidized sodium alginate-grafted dopamine/carboxymethyl chitosan/Fe3+ (OSD/CMC/Fe hydrogel)/polydopamine-encapsulated poly(thiophene-3-acetic acid) (OSD/CMC/Fe/PA hydrogel) were prepared for the repair infected wound. The Schiff base and Fe3+ coordination bonds structure are dynamic can be repaired automatically after network disrupted. Macroscopically, exhibits properties, allowing dressing adapt complex surfaces. OSD/CMC/Fe/PA showed conductivity photothermal properties under near-infrared (NIR) light irradiation. addition, hydrogels exhibit tunable rheological suitable mechanical antioxidant tissue adhesion hemostatic Furthermore, all improved healing in full-thickness defect skin test mice. size by OSD/CMC/Fe/PA3 + NIR was much smaller (12%) than control group treated Tegaderm™ film 14 days. conclusion, have high efficiency, conductivity, great biocompatibility, hemostasis making them promising candidates treatment wounds.

Language: Английский

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Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration

Biomaterials, Journal Year: 2021, Volume and Issue: 278, P. 121169 - 121169

Published: Oct. 1, 2021

Language: Английский

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Hydrogel tapes for fault-tolerant strong wet adhesion

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Dec. 9, 2021

Fast and strong bio-adhesives are in high demand for many biomedical applications, including closing wounds surgeries, fixing implantable devices, haemostasis. However, most rely on the instant formation of irreversible covalent crosslinks to provide surface binding. Repositioning misplaced adhesives during surgical operations may cause severe secondary damage tissues. Here, we report hydrogel tapes that can form physical interactions with tissues seconds gradually bonds hours. This timescale-dependent adhesion mechanism allows robust wet be combined fault-tolerant convenient operations. Specifically, inspired by catechol chemistry discovered mussel foot proteins, develop an electrical oxidation approach controllably oxidize catecholquinone, which reacts slowly amino groups tissue surface. We demonstrate show fast reversible at initial stage ultrastrong after linkages over hours various electronic devices. Given biocompatible, easy use, bio-adhesion, anticipate they find broad clinical applications.

Language: Английский

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Mussel‐ and Barnacle Cement Proteins‐Inspired Dual‐Bionic Bioadhesive with Repeatable Wet‐Tissue Adhesion, Multimodal Self‐Healing, and Antibacterial Capability for Nonpressing Hemostasis and Promoted Wound Healing

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(25)

Published: March 18, 2022

Abstract Massive bleeding and wound infection are the major problems often observed during severe trauma, achieving rapid hemostasis in cases of high‐dose arteries viscera remains an acute clinical demand. Herein, a mussel‐ barnacle cement proteins‐inspired dual‐bionic hydrogel is first proposed. Benefiting from abundant phenolic hydroxyl groups, tough dissipative matrix, removal interfacial water, as well dynamic redox balance phenol‐quinone, multinetwork achieves repeatable robust wet‐tissue adhesiveness (151.40 ± 1.50 kPa), fast multimodal self‐healing ability, excellent antibacterial property against both Gram‐positive/negative bacteria. For rabbit/pig models cardiac penetration holes femoral artery injuries, bioadhesive shows better hemostatic efficiency than commercial gauze due to synergistic effect strong sealing capability, red blood cell capturing property, activation barrier membrane. More interestingly, combined with sponge presents accelerated healing great potential for treating deep‐wound hemorrhage battlefield environment. Overall, owing these unique advantages, novel tissue‐adhesive hemostat opens up new avenue applications.

Language: Английский

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Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 287, P. 119336 - 119336

Published: March 11, 2022

Language: Английский

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Self-Healing, Wet-Adhesion silk fibroin conductive hydrogel as a wearable strain sensor for underwater applications

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 446, P. 136931 - 136931

Published: May 11, 2022

Language: Английский

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Progress in Hydrogels for Skin Wound Repair

Macromolecular Bioscience, Journal Year: 2022, Volume and Issue: 22(7)

Published: April 7, 2022

Abstract As the first defensive line between human body and outside world, skin is vulnerable to damage from external environment. Skin wounds can be divided into acute (mechanical injuries, chemical surgical wounds, etc.) chronic (burns, infections, diabetes, etc.). In order manage wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, hydrogels. Recently, hydrogels received much attention because their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, facile bioactive substance delivery capability. They show great potential application in repair. This paper introduces anatomy function skin, process healing conventional dressings, then composition construction methods Next, this necessary properties repair latest research progress hydrogel for Finally, future development goals materials field are proposed.

Language: Английский

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