International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7473 - 7473
Published: April 18, 2023
Antibiotic
resistance
is
one
of
the
greatest
threats
to
global
health
and
food
security
today.
It
becomes
increasingly
difficult
treat
infectious
disorders
because
antibiotics,
even
newest
ones,
are
becoming
less
effective.
One
ways
taken
in
Global
Plan
Action
announced
at
World
Health
Assembly
May
2015
ensure
prevention
treatment
diseases.
In
order
do
so,
attempts
made
develop
new
antimicrobial
therapeutics,
including
biomaterials
with
antibacterial
activity,
such
as
polycationic
polymers,
polypeptides,
polymeric
systems,
provide
non-antibiotic
therapeutic
agents,
selected
biologically
active
nanoparticles
chemical
compounds.
Another
key
issue
preventing
from
contamination
by
developing
packaging
materials,
particularly
based
on
degradable
polymers
biocomposites.
This
review,
a
cross-sectional
way,
describes
most
significant
research
activities
conducted
recent
years
field
development
materials
polymer
composites
properties.
We
focus
natural
i.e.,
polysaccharides
which
present
mechanism
for
combating
many
highly
pathogenic
microorganisms.
also
attempt
use
this
knowledge
obtain
synthetic
similar
activity.
Chemistry of Materials,
Journal Year:
2022,
Volume and Issue:
34(14), P. 6188 - 6209
Published: July 11, 2022
Polymers
with
precisely
controlled
structure
and
function
are
in
high
demand
across
a
diverse
array
of
applications
spanning
the
life
sciences
nanotechnology.
One
prototypical
example
is
class
branched
block
copolymers
known
as
miktoarm
stars
(μ-stars),
which
contain
two
or
more
arm
compositions
connected
at
common
junction.
Miktoarm
have
attracted
considerable
attention
since
their
physical
properties
can
be
different
from
conventional
linear
copolymers.
This
perspective
highlights
latest
developments
historical
context
field
star
polymers,
including
design
strategies,
synthetic
techniques,
advanced
characterization
tools
used
to
avoid
preparation
pitfalls
tailor
for
emerging
applications.
Our
contemporary
on
μ-star
polymers
resource
inspiring
future
research
into
this
exciting
materials
intersection
chemistry,
physics,
technology.
National Science Review,
Journal Year:
2022,
Volume and Issue:
9(8)
Published: Feb. 22, 2022
The
production
of
polypeptides
via
the
ring-opening
polymerization
(ROP)
N-carboxyanhydride
(NCA)
is
usually
conducted
under
stringent
anhydrous
conditions.
ROP
proline
NCA
(ProNCA)
for
synthesis
poly-L-proline
(PLP)
particularly
challenging
due
to
premature
product
precipitation
as
polyproline
type
I
helices,
leading
slow
reactions
up
one
week,
poor
control
molar
mass
and
laborious
workup.
Here,
we
report
unexpected
water-assisted
controlled
ProNCA,
which
affords
well-defined
PLP
II
helices
in
2-5
minutes
almost-quantitative
yields.
Experimental
theoretical
studies
together
suggest
as-yet-unreported
role
water
facilitating
proton
shift,
significantly
lowers
energy
barrier
chain
propagation.
scope
initiators
can
be
expanded
from
hydrophobic
amines
encompass
hydrophilic
thiol-bearing
nucleophiles,
including
complex
biomacromolecules
such
proteins.
Protein-mediated
ProNCA
conveniently
various
protein-PLP
conjugates
a
grafting-from
approach.
modification
not
only
preserves
biological
activities
native
proteins,
but
also
enhances
their
resistance
extreme
Moreover,
extends
elimination
half-life
asparaginase
(ASNase)
18-fold
mitigates
immunogenicity
wt
ASNase
>250-fold
(ASNase
first-line
anticancer
drug
lymphoma
treatment).
This
work
provides
simple
solution
long-standing
problem
synthesis,
offers
valuable
guidance
development
water-resistant
other
proline-like
NCAs.
facile
access
greatly
boost
application
potential
PLP-based
functional
materials
engineering
industry
enzymes
therapeutic
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(19), P. 3565 - 3569
Published: May 9, 2022
Direct
electrocarboxylation
of
various
N-acylimines
with
atmospheric
CO2
is
achieved
in
an
undivided
cell
under
mild
conditions,
affording
substituted
α-amino
acids
yields
62–95%.
This
reaction
conducted
high
efficiency
using
triethanolamine
as
external
reductant
nonsacrificial
anode
and
can
be
facilely
performed
on
gram
scale.
Preliminary
mechanistic
studies
including
cyclic
voltammetry
control
experiments
support
N-radical
carbanion
the
key
intermediate.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7473 - 7473
Published: April 18, 2023
Antibiotic
resistance
is
one
of
the
greatest
threats
to
global
health
and
food
security
today.
It
becomes
increasingly
difficult
treat
infectious
disorders
because
antibiotics,
even
newest
ones,
are
becoming
less
effective.
One
ways
taken
in
Global
Plan
Action
announced
at
World
Health
Assembly
May
2015
ensure
prevention
treatment
diseases.
In
order
do
so,
attempts
made
develop
new
antimicrobial
therapeutics,
including
biomaterials
with
antibacterial
activity,
such
as
polycationic
polymers,
polypeptides,
polymeric
systems,
provide
non-antibiotic
therapeutic
agents,
selected
biologically
active
nanoparticles
chemical
compounds.
Another
key
issue
preventing
from
contamination
by
developing
packaging
materials,
particularly
based
on
degradable
polymers
biocomposites.
This
review,
a
cross-sectional
way,
describes
most
significant
research
activities
conducted
recent
years
field
development
materials
polymer
composites
properties.
We
focus
natural
i.e.,
polysaccharides
which
present
mechanism
for
combating
many
highly
pathogenic
microorganisms.
also
attempt
use
this
knowledge
obtain
synthetic
similar
activity.
