Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5604 - 5640

Published: Jan. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Language: Английский

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Bioinspired double network hydrogels: from covalent double network hydrogelsviahybrid double network hydrogels to physical double network hydrogels

Materials Horizons, Journal Year: 2020, Volume and Issue: 8(4), P. 1173 - 1188

Published: Dec. 10, 2020

This minireview discusses the advantages and challenges in constructing bioinspired double-network hydrogels mimicking structure and/or properties of biological tissue.

Language: Английский

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Alginate and its application to tissue engineering

SN Applied Sciences, Journal Year: 2021, Volume and Issue: 3(1)

Published: Jan. 1, 2021

Abstract Alginate is a polysaccharide of natural origin, which shows outstanding properties biocompatibility, gel forming ability, non-toxicity, biodegradability and easy to process. Due these excellent alginate, sodium hydrogel form oxidized alginate other based materials are used in various biomedical fields, especially drug delivery, wound healing tissue engineering. can be easily processed as the 3D scaffolding includes hydrogels, microcapsules, microspheres, foams, sponges, fibers bio-polymeric have particularly healing, bone injuries, scars, wound, cartilage repair treatment, new regeneration, scaffolds for cell growth. modified blended by adopting some physical chemical processes derivative obtained different structures, functions, having improved mechanical strength, affinity property gelation. This attained due combination with biomaterials, crosslinking, immobilization definite ligands (sugar peptide molecules). Hence its forms, composite found more attractive towards article provides comprehensive outline properties, structural aspects, application

Language: Английский

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Tailoring Gelation Mechanisms for Advanced Hydrogel Applications

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(42)

Published: Aug. 18, 2020

Abstract Hydrogels are one of the most commonly explored classes biomaterials. Their chemical and structural versatility has enabled their use across a wide range applications, including tissue engineering, drug delivery, cell culture. form upon sol–gel transition, which can be elicited by different triggers designed to enable precise control over hydrogelation kinetics hydrogel structure. The chosen trigger chemistry have profound effect on success targeted application. In this Progress Report, critical overview recent advances in design is presented, with focus available strategies used formation networks (e.g., temperature, light, ultrasound). These presented within new classification system, suitability for six key hydrogel‐based applications assessed. This Report intended guide selection inspire rational mechanisms.

Language: Английский

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2D and 3D electrospinning technologies for the fabrication of nanofibrous scaffolds for skin tissue engineering: A review

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2020, Volume and Issue: 12(4)

Published: March 12, 2020

Abstract This review provides insights into the current advancements in field of electrospinning, focusing on its applications for skin tissue engineering. Furthermore, it reports evolvement and present challenges advanced substitute product development explores recent contributions 2D 3D scaffolding, natural, synthetic, composite nanomaterials. In past decades, nanotechnology has arisen as a fascinating discipline that influenced every aspect science, engineering, medicine. Electrospinning is versatile fabrication method allows researchers to elicit explore many faced by engineering regenerative electrospun nanofibers are particularly attractive due their refined morphology, processing flexibility—that formation unique materials structures, extracellular matrix‐like biomimetic architecture. These allow promote improved re‐epithelization neo‐tissue wounds. Advancements use portable electrospinning equipment employment transdermal drug delivery melanoma treatment additionally explored. Present trends issues critically discussed based recently published patents, clinical trials, vivo studies. article categorized under: Implantable Materials Surgical Technologies > Nanotechnology Tissue Repair Replacement Therapeutic Approaches Drug Discovery Emerging Nanomaterials Implants

Language: Английский

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Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials

Carbohydrate Polymers, Journal Year: 2020, Volume and Issue: 250, P. 116922 - 116922

Published: Aug. 16, 2020

Language: Английский

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Physically cross-linked chitosan-based hydrogels for tissue engineering applications: A state-of-the-art review

European Polymer Journal, Journal Year: 2021, Volume and Issue: 145, P. 110176 - 110176

Published: Jan. 17, 2021

Language: Английский

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Covalently Crosslinked Hydrogels via Step‐Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(25)

Published: May 14, 2021

Abstract Hydrogels are an important class of biomaterials with the unique property high‐water content in a crosslinked polymer network. In particular, chemically hydrogels have made great clinical impact past years because their desirable mechanical properties and tunability structural chemical properties. Various polymers step‐growth crosslinking chemistries harnessed for fabricating such covalently translational research. However, selecting appropriate intended application is time‐consuming challenging. It requires integration chemistry knowledge thoughtful reaction design. This task becomes even more challenging when other factors as biological mechanisms pathology, practical administration routes, regulatory requirements add additional constraints. this review, key features commonly used preparing translatable outlined performance systems summarized. The examples effective polymer/crosslinking combinations that yielded clinically approved hydrogel products specifically highlighted. These design parameters context process translation barriers, providing guideline rational selection to construct high potential further considered.

Language: Английский

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Hydrogel membranes: A review

Materials Science and Engineering C, Journal Year: 2020, Volume and Issue: 114, P. 111023 - 111023

Published: April 29, 2020

Language: Английский

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Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Polymers, Journal Year: 2020, Volume and Issue: 12(4), P. 844 - 844

Published: April 6, 2020

Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, may not provide suitable support cell adhesion, proliferation, and differentiation, which decelerates regeneration. To improve biological properties, frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, cytokines. Although there many papers describing synthesis properties of polymer proteins or few reviews comprehensively summarize these molecules. Thus, this review presents the current knowledge about most important peptides used modification This paper also describes influence addition on physicochemical, mechanical, scaffolds. Moreover, article sums up major applications biodegradable natural synthetic modified have been developed within past five years.

Language: Английский

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