Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(16), P. 6200 - 6205
Published: Aug. 2, 2021
Herein,
we
report
a
highly
efficient
ruthenium-catalyzed
peri-selective
C(sp2)–H
acylmethylation
of
1-naphthols
with
α-carbonyl
sulfoxonium
ylides
by
utilizing
hydroxyl
as
weakly
coordinating
directing
group.
This
new
method
imparts
good
reactivity,
excellent
chemo-
and
regioselectivity,
broad
functional
group
tolerance
involves
mild
reaction
conditions.
The
C–H
acylmethylated
products
can
be
readily
cyclized
into
fluorescent
annulated
pyrans
one-pot
process.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(24), P. 17479 - 17646
Published: Oct. 14, 2022
Alkenes
and
their
derivatives
are
featured
widely
in
a
variety
of
natural
products,
pharmaceuticals,
advanced
materials.
Significant
efforts
have
been
made
toward
the
development
new
practical
methods
to
access
this
important
class
compounds
by
selectively
activating
alkenyl
C(sp2)–H
bonds
recent
years.
In
comprehensive
review,
we
describe
state-of-the-art
strategies
for
direct
functionalization
sp2
C–H
C–F
until
June
2022.
Moreover,
metal-free,
photoredox,
electrochemical
also
covered.
For
clarity,
review
has
divided
into
two
parts;
first
part
focuses
on
currently
available
using
different
alkene
as
starting
materials,
second
describes
bond
easily
accessible
gem-difluoroalkenes
material.
This
includes
scope,
limitations,
mechanistic
studies,
stereoselective
control
(using
directing
groups
well
metal-migration
strategies),
applications
complex
molecule
synthesis
where
appropriate.
Overall,
aims
document
considerable
advancements,
current
status,
emerging
work
critically
summarizing
contributions
researchers
working
fascinating
area
is
expected
stimulate
novel,
innovative,
broadly
applicable
functionalizations
coming
Organic Chemistry Frontiers,
Journal Year:
2020,
Volume and Issue:
7(19), P. 3100 - 3119
Published: Jan. 1, 2020
This
review
highlights
recent
progress
in
tandem
selenocyclization
and
tellurocyclization
with
alkenes
alkynes,
an
emphasis
on
the
scopes,
limitations
mechanisms
of
these
different
reactions.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(6), P. 3452 - 3506
Published: March 3, 2022
Transition-metal-catalyzed
C–H
bond
functionalizations
have
had
an
enormous
influence
on
organic
synthesis
in
recent
times.
However,
the
use
of
low-abundance
4d
and
5d
metals
is
almost
inevitable,
they
are
high
demand.
This
will
be
a
cause
concern,
hence,
it
important
to
develop
methods
based
3d
metals,
which
widely
present
Earth's
crust.
In
this
regard,
metal
catalysts
or
their
precursors
for
catalysis,
general,
functionalizations,
particular,
has
gained
significant
momentum
The
major
development
catalytic
with
been
achieved
predominantly
strongly
coordinating
directing
groups
such
as
pyridyl,
pyrimidinyl,
pyrazolyl,
8-amino-quinolinyl
groups.
Thus,
prefunctionalization
substrates
these
necessary,
contradicts
step-
atom-economy
activation.
commonly
available
functional
aldehyde,
ketone,
carboxylic
acid,
amide,
hydroxy,
N-oxides
loosely
bind
through
weak-coordination.
These
weakly
orient
activate
regioselectively
without
need
preinstalled
Although
challenging,
contemporary
topic
actively
pursued
by
many
researchers
Through
article,
we
provide
comprehensive
overview
metal-catalyzed,
coordinating,
directing-group-enabled
reported
until
March
2021.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(22), P. 4835 - 4839
Published: May 29, 2024
A
three-component
cascade
reaction
involving
cyclohexanones,
anilines,
and
diaryl
diselenides
under
metal-free
conditions
is
reported.
The
ortho-selenation
of
cyclohexanones
with
diselenides,
followed
by
sequential
dehydroaromatization
enables
the
preparation
a
variety
o-selanyl
anilines
in
moderate
to
excellent
yields.
This
innovative
transformation
notable
for
its
tolerance
functional
groups
suitable
late-stage
modification
complex
pharmaceuticals.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
11(2), P. 597 - 630
Published: Nov. 23, 2023
This
review
highlights
the
recent
progress
in
electrochemical
difunctionalization
of
alkenes
and
alkynes
involving
C–S/Se
bond
formation
to
access
organochalcogen
frameworks.
Chemistry - An Asian Journal,
Journal Year:
2020,
Volume and Issue:
15(14), P. 2092 - 2109
Published: June 5, 2020
2-Pyridone
is
a
ubiquitous
motif
in
natural
products,
drug
molecules,
ligands
catalysis
and
organic
materials.
There
necessity
of
direct
step-economic
methods
for
the
construction
2-pyridone
based
molecules.
Strategically,
primary
developments
have
led
to
C3-functionalizations
due
inherent
reactivity
this
center.
Despite
this,
many
elegant
transition
metal-catalysed
been
established
introduce
versatile
functional
groups
at
C4,
C5
C6-position
via
C-H
bond
functionalizations.
This
minireview
focuses
on
categorized
introduction
different
scaffolds
beyond
C3-selectivity
discusses
substrate
scope,
limitations
plausible
mechanistic
details.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(22), P. 16045 - 16058
Published: July 30, 2021
A
catalyst-free,
environmentally
friendly,
and
efficient
electrochemical
selenylation/cyclization
of
alkenes
has
been
developed
with
moderate
to
excellent
yields.
This
selenylated
transformation
proceeds
smoothly
tolerates
a
wide
range
synthetically
useful
groups
deliver
diverse
functionalized
benzheterocycles,
including
iminoisobenzofuran,
lactones,
oxindoles,
quinolinones.
Moreover,
the
present
synthetic
route
could
also
be
readily
scaled
up
gram
quantity
convenient
operation
in
an
undivided
cell.
Advanced Synthesis & Catalysis,
Journal Year:
2021,
Volume and Issue:
363(14), P. 3411 - 3438
Published: April 16, 2021
Abstract
Functionalized
coumarins
are
privileged
scaffolds
which
display
diverse
pharmacological
and
physiological
activities,
a
myriad
of
applications
in
medical
science
biomedical
research.
Owing
to
these
multifarious
activities
coumarins,
synthetic
chemists
actively
engaged
developing
new
superior
methods
for
their
synthesis.
In
the
last
decade,
synthesis
functionalized
via
visible
light‐induced
methodologies
has
turned
into
one
most
significant
fundamental
missions
organic
This
review
covers
literature
on
under
light‐assisted
methodologies.
magnified
image
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(19), P. 4972 - 5027
Published: Jan. 1, 2023
This
review
comprehensively
summarizes
the
dichalcogenative
functionalization
of
unsaturated
compounds
over
past
decade.
The
scopes,
limitations
and
detailed
reaction
mechanisms
are
also
discussed.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(9), P. 5572 - 5585
Published: April 21, 2023
Organoselenium
compounds
are
important
scaffolds
in
pharmaceutical
molecules.
Herein,
we
report
metal-free,
electrochemical,
highly
chemo-
and
regioselective
synthesis
of
gem-diselenides
through
the
coupling
α-keto
sulfoxonium
ylides
with
diselenides.
The
versatility
electrochemical
manifold
enabled
selenylation
ample
scope
broad
functional
group
tolerance,
as
well
setting
stage
for
modification
complex
bioactive
Detailed
mechanistic
studies
revealed
that
key
C-Se
bond
was
constructed
using
n-Bu4NI
an
electrolyte
catalyst
electrosynthetic
protocol.
Finally,
desired
showed
excellent
antimicrobial
activity
against
Candida
albicans,
which
can
be
identified
lead
further
exploration.
