Biomaterials Science, Journal Year: 2020, Volume and Issue: 8(9), P. 2404 - 2419
Published: Jan. 1, 2020
First report on the effect of topology design biodegradation, mechanical properties, and cell responses additively manufactured Zn.
Language: Английский
Journal of Orthopaedic Translation, Journal Year: 2023, Volume and Issue: 42, P. 94 - 112
Published: Sept. 1, 2023
Currently, metal implants are widely used in orthopedic surgeries, including fracture fixation, spinal fusion, joint replacement, and bone tumor defect repair. However, conventional difficult to be customized according the recipient's skeletal anatomy characteristics, leading difficulties meeting individual needs of patients. Additive manufacturing (AM) or three-dimensional (3D) printing technology, an advanced digital fabrication technique capable producing components with complex precise structures, offers opportunities for personalization. We systematically reviewed literature on 3D over past 10 years. Relevant animal, cellular, clinical studies were searched PubMed Web Science. In this paper, we introduce method characteristics biometals summarize properties their applications surgery. On basis, discuss potential possibilities further generalization improvement. technology has facilitated use different procedures. By combining medical images from techniques such as CT MRI, allows based injured tissue. Such patient-specific not only reduce excessive mechanical strength eliminate stress-shielding effects, but also improve biocompatibility functionality, increase cell nutrient permeability, promote angiogenesis growth. addition, advantages low cost, fast cycles, high reproducibility, which can shorten patients' surgery hospitalization time. Many trials have been conducted using implants. modeling software, operation equipment, demand implant materials, lack guidance relevant laws regulations limited its application. There personalization, promotion osseointegration, short production cycle, material utilization. With continuous learning software by surgeons, improvement development materials that better meet needs, regulations, applied more surgeries. Precision, intelligence, personalization future direction orthopedics. It is reasonable believe will deeply integrated artificial 4D printing, big data play a greater role eventually become important part economy. aim latest developments engineers surgeons design closely mimic morphology function native bone.
Language: Английский
Citations
100
International Journal of Heat and Mass Transfer, Journal Year: 2022, Volume and Issue: 198, P. 123352 - 123352
Published: Sept. 11, 2022
Language: Английский
Citations
80
Journal of Materials Research and Technology, Journal Year: 2022, Volume and Issue: 17, P. 1408 - 1426
Published: Jan. 25, 2022
Additive manufacturing (AM) enables fully dense biomimetic implants in the designed geometries from preferred materials such as titanium and its alloys. Titanium aluminum vanadium (Ti6Al4V) is one of pioneer metal alloys for bone implant applications, however, reasons eliminating toxic effects Ti6Al4V maintaining adequate mechanical strength have increased potential commercially pure (cp-Ti) to be used implants. This literature review aims evaluate production cp-Ti biomedical with laser powder bed fusion (L-PBF) technology, which has a very high level technological matureness industrialization level. The optimization L-PBF parameters post-processing techniques affect obtained microstructure leading various mechanical, corrosion biological behaviors manufactured titanium. All features are considered light specifications needs applications. most critical disadvantages residual stresses deformations introduced solutions discussed. Moreover, manufacturability porous that causes benefit harm applications assessed.
Language: Английский
Citations
75
Metals, Journal Year: 2022, Volume and Issue: 12(4), P. 687 - 687
Published: April 16, 2022
Ti-6Al-4V (Ti64) alloy is one of the most widely used orthopedic implant materials due to its mechanical properties, corrosion resistance, and biocompatibility nature. Porous Ti64 structures are gaining more research interest as bone implants they can help in reducing stress-shielding effect when compared their solid counterpart. The literature shows that porous fabricated using different additive manufacturing (AM) process routes, such laser powder bed fusion (L-PBF) electron beam melting (EBM) be tailored mimic properties natural bone. This review paper categorizes designs into non-gradient (uniform) gradient (non-uniform) structures. Gradient design appears promising for applications closeness towards morphology improved properties. In addition, this outlines details on structure fatigue behavior, multifunctional designs, current challenges, gaps studies implants.
Language: Английский
Citations
72
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26641 - e26641
Published: Feb. 23, 2024
Additive Manufacturing (AM) has recently demonstrated significant medical progress. Due to advancements in materials and methodologies, various processes have been developed cater the sector's requirements, including bioprinting 4D, 5D, 6D printing. However, only a few studies captured these emerging trends their applications. Therefore, this overview presents an analysis of achievements obtained AM for industry, focusing on principal identified annual report AM3DP.
Language: Английский
Citations
26
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 19, 2024
There has been increasing attention to produce porous scaffolds that mimic human bone properties for enhancement of tissue ingrowth, regeneration, and integration. Additive manufacturing (AM) technologies, i.e., three dimensional (3D) printing, have played a substantial role in engineering clinical applications owing their high level design fabrication flexibility. To this end, review article attempts provide detailed overview on the main considerations such as permeability, adhesion, vascularisation, interfacial features interplay affect regeneration osseointegration. Physiology was initially explained followed by analysing impacts porosity, pore size, permeability surface chemistry defects. Importantly, major 3D printing methods employed substitutes were also discussed. Advancements MA technologies allowed production with complex geometries polymers, composites metals well-tailored architectural, mechanical, mass transport features. In way, particular devoted reviewing printed triply periodic minimal (TPMS) hierarchical structure bones. overall, enlighten pathway patient-specific 3D-printed substitutions osseointegration capacity repairing large
Language: Английский
Citations
23
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 4, 2025
Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and formation. Conventional treatments, such as pharmaceutical drugs hormone replacement therapy, often yield suboptimal are frequently associated with side effects. Recently, biomaterial-based approaches have gained attention promising alternatives for managing osteoporosis. This review summarizes the current advancements 3D-printed biomaterials designed osteoporosis treatment. The benefits of compared to traditional systemic drug therapies discussed. These materials can be broadly categorized based on their functionalities, including promoting osteogenesis, reducing inflammation, exhibiting antioxidant properties, inhibiting osteoclast activity. 3D printing has advantages speed, precision, personalization, etc. It is able satisfy requirements irregular geometry, differentiated composition, multilayered structure articular osteochondral scaffolds boundary layer structure. limitations existing critically analyzed future directions considered.
Language: Английский
Citations
2
Journal of Material Science and Technology, Journal Year: 2020, Volume and Issue: 76, P. 129 - 149
Published: Nov. 6, 2020
Language: Английский
Citations
132
Acta Biomaterialia, Journal Year: 2019, Volume and Issue: 101, P. 609 - 623
Published: Oct. 28, 2019
Language: Английский
Citations
132
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2020, Volume and Issue: 105, P. 103671 - 103671
Published: Feb. 6, 2020
Language: Английский
Citations
122