Environmental impact of the reported chromatographic methods for the determination of the first FDA-Approved therapy for COVID-19 Patients, Remdesivir: A comparative study DOI
Amal B. Ahmed, Mohammed Gamal, Ibrahim A. Naguib

et al.

Microchemical Journal, Journal Year: 2022, Volume and Issue: 176, P. 107242 - 107242

Published: Jan. 30, 2022

Language: Английский

Sustainable and white HPLC method for simultaneous determination of amlodipine and atorvastatin in film-coated tablet DOI Creative Commons

Marija Tomikj,

Marijana Božinovska,

Natasha Anevska-Stojanovska

et al.

Green Analytical Chemistry, Journal Year: 2024, Volume and Issue: 8, P. 100103 - 100103

Published: Feb. 17, 2024

Language: Английский

Citations

10
Sustainable quantification of glycopyrronium, indacaterol, and mometasone along with two genotoxic impurities in a recently approved fixed-dose breezhaler formulations and biological fluids: A machine learning-augmented UV-spectroscopic approach DOI
Ahmed Emad F. Abbas, Mohammed Gamal, Ibrahim A. Naguib

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 206, P. 111586 - 111586

Published: Sept. 6, 2024

Language: Английский

Citations

9
Two chromatographic methods for analyzing paracetamol in spiked human plasma with its toxic metabolite, N-acetyl parabenzoquinone imine and its antidote, N-acetyl-l-cysteine DOI Creative Commons
Omar M El‐Abassy, Michael Gamal Fawzy,

Ebraam B. Kamel

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 3, 2025

Abstract Acetaminophen, also known as paracetamol (APAP), is a highly utilized pharmaceutical agent on global scale, particularly in the field of pediatrics. Regrettably, an overdose APAP, resulting from predominant oxidation, has potential to trigger acute liver injury. The study’s goal was find easy, accurate, and selective way measure N -acetyl para benzoquinone imine (NAPQI) (an APAP metabolite that harmful), -acetyl- l -cysteine (NAC) antidote). Two different chromatographic methods were used. HPTLC method, which used silica gel 60 F 254 stationary phase developing liquid made up methanol, ethyl acetate, glacial acetic acid (8:2:0.2, v/v/v) UV detection at nm. HPLC method developed using mobile consisting water, formic proportion (70:30:0.15, v/v/v). approach C 18 column. Analytes quantification established utilizing detector operating wavelength present make it possible amount plasma samples. When comes pharmacokinetics or medication levels children’s plasma, for example, this may be very helpful. current can quantify NAPQI, helpful figuring out drug concentrations individuals with intoxication diagnoses. Additionally, approaches estimate NAC antidote; result, study complete because analyse drug, toxic metabolite, antidote one analytical run. Using innovative blue applicability grade index software, measures practicality procedures, both methodologies compared reported methods. achievement eco-friendliness profile designed procedures assessed. Both techniques passed ICH validation tests.

Language: Английский

Citations

1
Comparative study of two versatile multi-analyte chromatographic methods for determination of diacerein together with four non-steroidal anti-inflammatory drugs: Greenness appraisal using Analytical Eco-Scale and AGREE metrics DOI
Dina S. El‐Kafrawy,

Amira H. Abo-Gharam,

Abdel-Khalek Mm

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2022, Volume and Issue: 28, P. 100709 - 100709

Published: May 18, 2022

Language: Английский

Citations

36
Environmental impact of the reported chromatographic methods for the determination of the first FDA-Approved therapy for COVID-19 Patients, Remdesivir: A comparative study DOI
Amal B. Ahmed, Mohammed Gamal, Ibrahim A. Naguib

et al.

Microchemical Journal, Journal Year: 2022, Volume and Issue: 176, P. 107242 - 107242

Published: Jan. 30, 2022

Language: Английский

Citations

35