AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)
Published: March 4, 2025
Language: Английский
Pharmaceutical Development and Technology, Journal Year: 2022, Volume and Issue: 27(5), P. 525 - 544
Published: May 28, 2022
The bioavailability of drugs is dependent on several factors such as solubility and the administration route. A drug with poor aqueous solubility, therefore, poses challenges regards to its pharmaceutical advance ultimately biological usage. Lipid nanoparticles have been used in science due their importance green chemistry. Their biochemical properties ‘green’ materials processes mean they can be environmentally sustainable. Generally, lipid employed carriers for both lipophilic hydrophilic drugs. proposed route present advantages disadvantages which should considered by a formulator. Solid (SLNs) nanostructured (NLCs) are attractive delivery systems because ease manufacture, biocompatibility, biodegradability, scale-up capacity formulation constituents. easy simple scalability novel SLNs nano carriers, along various processing procedures, recent developments, limitation toxicity, optimization approaches manufacture nanoparticles, lyophilization release comprehensively discussed this review. This review also summarizes research data related preparation methods excipients NLCs years.
Language: Английский
Citations
84
Nanoscale Advances, Journal Year: 2022, Volume and Issue: 4(21), P. 4447 - 4469
Published: Jan. 1, 2022
Lignin, one of the most abundant biopolymers on earth, has been traditionally considered a low-value by-product pulp and paper industries. This renewable raw material, besides being source valuable molecules for chemical industry, also antioxidant, UV-absorbing, antibacterial properties in its macromolecular form. Moreover, lignin form nanoparticles (LigNPs) presents advantages over bulk lignin, such as higher reactivity due to larger surface-to-volume ratio. In view rapid surge antimicrobial resistance (AMR), caused by overuse antibiotics, continuous development novel agents is needed. The use LigNPs suitable alternative conventional antibiotics topical application or disinfectants surfaces packaging. Besides, their multiple unspecific targets bacterial cell may prevent emergence AMR. review summarizes latest developments nano-formulated both dispersion embedded materials. following roles formulation NPs have analyzed: (i) an active nanoformulations, (ii) reducing capping agent metals, (iii) carrier other agents. Finally, covers inclusion films, fibers, hydrogels, foams, obtaining lignin-based nanocomposites variety applications, including food packaging, wound healing, medical coatings.
Language: Английский
Citations
79
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(3), P. 424 - 424
Published: Jan. 19, 2023
Selenium is an important dietary supplement and essential trace element incorporated into selenoproteins with growth-modulating properties cytotoxic mechanisms of action. However, different compounds selenium usually possess a narrow nutritional or therapeutic window low degree absorption delicate safety margins, depending on the dose chemical form in which they are provided to organism. Hence, nanoparticles (SeNPs) emerging as novel diagnostic platform decreased toxicity capacity enhance biological Se-based compounds. Consistent exciting possibilities offered by nanotechnology diagnosis, treatment, prevention diseases, SeNPs useful tools current biomedical research exceptional benefits potential therapeutics, enhanced bioavailability, improved targeting, effectiveness against oxidative stress inflammation-mediated disorders. In view need for developing eco-friendly, inexpensive, simple, high-throughput agents that can also ally theranostic purposes exhibit negligible side effects, biogenic receiving special attention. The present manuscript aims be reference its kind providing readership thorough comprehensive review emphasizes current, yet expanding, field promise hold among selenium-derived products to, eventually, elicit future developments. First, recalls physiological importance oligo-element introduces unique biological, physicochemical, optoelectronic, catalytic Se nanomaterials. Then, it addresses significance nanosizing pharmacological activity (pharmacokinetics pharmacodynamics) cellular interactions SeNPs. Importantly, discusses detail role biosynthesized innovative personalized nanomedicine-based therapies. Finally, this explores ongoing context SARS-CoV-2 pandemic presents key prospects translational nanomedicine.
Language: Английский
Citations
70
Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899
Published: July 9, 2024
This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.
Language: Английский
Citations
62
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 417 - 417
Published: Jan. 26, 2023
Electrospinning is the simplest and most widely used technology for producing ultra-thin fibers. During electrospinning, high voltage causes a thin jet to be launched from liquid polymer then deposited onto grounded collector. Depending on type of fluid, solution melt electrospinning are distinguished. The morphology physicochemical properties produced fibers depend many factors, which can categorized into three groups: process parameters, material properties, ambient parameters. In biomedical field, electrospun nanofibers have wide variety applications ranging medication delivery systems tissue engineering scaffolds soft electronics. Many these showed promising results potential use as medical devices in future. Medical cure, prevent, or diagnose diseases without presence any active pharmaceutical ingredients. regulation conventional strict carefully controlled; however, it not yet properly defined case nanotechnology-made devices. This review divided two parts. first part provides an overview through several examples, while second focuses developments field Additionally, relevant regulatory framework summarized at end this paper.
Language: Английский
Citations
54
Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14
Published: May 12, 2023
Background: Rapid advancements in research and development related to nanomedical technology raise various ethical legal challenges areas relevant disease detection, diagnosis, treatment. This study aims outline the existing literature, covering issues associated with emerging nanomedicine clinical research, identify implications for responsible advancement integration of throughout medical networks future. Methods: A scoping review, designed cover scientific, ethical, literature technology, was conducted, generating analyzing 27 peer-reviewed articles published between 2007-2020. Results: Results indicate that referencing were concerned six key areas: 1) harm exposure potential risks health, 2) consent nano-research, 3) privacy, 4) access therapies, 5) classification products relation 6) precautionary principle as it relates technology. Conclusion: review suggests few practical solutions are comprehensive enough allay concerns surrounding fields especially continues evolve contribute future innovations medicine. It is also clearly apparent a more coordinated approach required ensure global standards practice governing discussions regulation mainly confined systems governance United States.
Language: Английский
Citations
47
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(2), P. 131 - 131
Published: Jan. 5, 2024
Nanoparticle transport into plants is an evolving field of research with diverse applications in agriculture and biotechnology. This article provides overview the challenges prospects associated nanoparticles plants, focusing on delivery methods detection within plant tissues. Passive assisted methods, including use roots leaves as introduction sites, are discussed, along their respective advantages limitations. The barriers encountered nanoparticle to highlighted, emphasizing need for innovative approaches (e.g., stem a new recognition site) optimize efficiency. In recent years, efforts have intensified, leading evendeeper understanding intricate mechanisms governing interaction nanomaterials tissues cells. Investigations uptake pathways translocation revealed nuanced responses different types nanoparticles. Additionally, this delves importance studying localization quantification Various techniques presented valuable tools comprehensively nanoparticle–plant interactions. reliance multiple data validation emphasized enhance reliability findings. future outlooks explored, potential alternative such stems, continued development formulations that improve adhesion penetration. By addressing these fostering multidisciplinary research, poised make significant contributions sustainable environmental management.
Language: Английский
Citations
46
Environmental Pollution, Journal Year: 2024, Volume and Issue: 346, P. 123617 - 123617
Published: Feb. 21, 2024
Language: Английский
Citations
43
Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(6), P. 1583 - 1610
Published: Jan. 1, 2024
Nanotechnology is a relatively new technological field, therefore, the information about associated risk of nanomaterials in environmental and human health must be addressed consolidated to develop accurate legislations, frameworks, guidelines standardise safe use any field.
Language: Английский
Citations
36
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(19)
Published: Jan. 11, 2024
Abstract Cancer, responsible for approximately 10 million lives annually, urgently requires innovative treatments, as well solutions to mitigate the limitations of traditional chemotherapy, such long‐term adverse side effects and multidrug resistance. This review focuses on Carbon Dots (CDs), an emergent class nanoparticles (NPs) with remarkable physicochemical biological properties, their burgeoning applications in bioimaging nanocarriers drug delivery systems cancer treatment. The initiates overview NPs nanocarriers, followed by in‐depth look into barriers that could affect distribution, from administration, intracellular trafficking. It further explores CDs′ synthesis, including both bottom‐up top‐down approaches, notable biocompatibility, supported a selection vitro, vivo , ex studies. Special attention is given role bioimaging, highlighting optical properties. discussion extends emerging significance carriers, particularly doxorubicin other anticancer agents, underscoring recent advancements challenges this field. Finally, we showcase examples promising bioapplications CDs, owing flexible design. As research CDs evolves, envisage key challenges, potential CD‐based therapy.
Language: Английский
Citations
34