Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: March 27, 2023
Abstract
In
this
investigation,
pressure
microwave
irradiation
was
used
to
clarify
the
activity
of
1-(2-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one
(3)
towards
several
active
methylene
derivatives
utilized
pressurized
as
green
energy
resource
.
Chalcone
3
allowed
react
with
ethyl
cyanoacetate,
acetylacetone,
and
thioglycolic
acid;
respectively,
at
70
°C
under
reaction
condition
afford
corresponding
2-hydroxyphenylcyanopyridone,
2-hydroxyphenyl
acetylcyclohexanone,
thieno[2,3-
c
]chromen-4-one
respectively.
Moreover,
chalcone
hydrogen
peroxide
stirring
affords
chromen-4-one
derivative.
All
synthesized
compounds
were
confirmed
through
spectral
tools
such
FT-IR,
1
HNMR,
13
CNMR,
mass
spectrum.
Furthermore,
heterocycles
exhibited
excellent
antioxidant
comparable
vitamin
C,
where
presence
OH
group
increases
scavenger
radical
inhibition.
biological
compound
12
demonstrated
molecular
docking
stimulation
using
two
proteins,
PDBID:
1DH2
3RP8,
which
showed
that
possesses
greater
binding
a
shorter
bond
length
ascorbic
acid.
Also,
optimized
DFT/B3LYP/6-31G
(d,p)
basis
set
identification
their
physical
descriptors,
whereas
X-Ray
single
structure
Hirsh
field
analysis
know
electrostatic
interaction,
correlated
by
comparing
length,
angle,
NMR,
gave
correlation.
Materials Horizons,
Journal Year:
2021,
Volume and Issue:
8(6), P. 1618 - 1633
Published: Jan. 1, 2021
This
review
focuses
on
the
recent
progress
in
polydopamine
antibacterial
materials,
including
their
structural
and
functional
features,
preparation
strategies,
mechanisms,
biomedical
applications.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(14), P. 8319 - 8343
Published: Jan. 1, 2021
This
review
provides
in-depth
insight
into
the
structural
engineering
of
PDA-based
materials
to
enhance
their
responsive
feature
and
use
them
in
construction
stimuli-responsive
smart
materials.
Materials Horizons,
Journal Year:
2020,
Volume and Issue:
8(1), P. 145 - 167
Published: Sept. 17, 2020
Polyphenols
are
a
class
of
ubiquitous
compounds
distributed
in
nature,
with
fascinating
inherent
biocompatible,
bioadhesive,
antioxidant,
and
antibacterial
properties.
The
unique
polyphenolic
structures
based
on
catechol
or
pyrogallol
moieties
allow
for
strong
non-covalent
interactions
(e.g.,
multiple
hydrogen
bonding,
electrostatic,
cation-π
interactions)
as
well
covalent
Michael
addition/Schiff-base
reaction,
radical
coupling
dynamic
coordination
boronate
metal
ions).
This
review
article
provides
an
overview
the
polyphenol-based
scaffolds
including
hydrogels,
films,
nanofibers
that
have
emerged
from
chemical
functional
signatures
during
past
years.
A
full
description
structure-function
relationships
terms
their
utilization
wound
healing,
bone
regeneration,
electroactive
tissue
engineering
is
also
carefully
discussed,
which
may
pave
path
towards
rational
design
facile
preparation
next-generation
polyphenol
applications.
ACS Applied Materials & Interfaces,
Journal Year:
2021,
Volume and Issue:
13(6), P. 7617 - 7624
Published: Feb. 4, 2021
A
solar
steam
generation
method
has
been
widely
investigated
as
a
sustainable
to
achieve
seawater
desalination
and
sewage
treatment.
However,
oil
pollutants
are
usually
emitted
in
real
or
wastewaters,
which
can
cause
serious
fouling
problems
disturb
the
evaporation
performance.
In
this
work,
mussel-inspired,
low-cost,
polydopamine-filled
cellulose
aerogel
(PDA-CA)
rationally
designed
fabricated
with
both
superhydrophilicity
underwater
superoleophobicity.
The
resulting
PDA-CA
device
could
also
high
rate
of
1.36
kg
m–1
h–1
an
86%
energy
utilize
efficiency
under
1
sun
illumination.
addition,
not
only
exhibited
promising
antifouling
capacity
for
long-term
water
but
engaged
effective
adsorption
organic
dye
contaminants.
These
features
may
offer
new
opportunities
developing
multifunctional
photothermal
devices
solar-driven
remediation.
Journal of Hematology & Oncology,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: Nov. 30, 2023
Inflammation
is
a
fundamental
defensive
response
to
harmful
stimuli,
but
the
overactivation
of
inflammatory
responses
associated
with
most
human
diseases.
Reactive
oxygen
species
(ROS)
are
class
chemicals
that
generated
after
incomplete
reduction
molecular
oxygen.
At
moderate
levels,
ROS
function
as
critical
signaling
molecules
in
modulation
various
physiological
functions,
including
responses.
However,
at
excessive
exert
toxic
effects
and
directly
oxidize
biological
macromolecules,
such
proteins,
nucleic
acids
lipids,
further
exacerbating
development
causing
Therefore,
designing
manufacturing
biomaterials
scavenge
has
emerged
an
important
approach
for
restoring
homeostasis,
limiting
protecting
host
against
damage.
This
review
systematically
outlines
dynamic
balance
production
clearance
under
conditions.
We
focus
on
mechanisms
by
which
regulate
cell
proteins
how
these
affect
inflammation.
Furthermore,
we
discuss
use
potential
currently
available-biomaterials
ROS,
agents
were
engineered
reduce
levels
blocking
generation,
chemically
reacting
or
catalytically
accelerating
clearance,
treatment
Finally,
evaluate
challenges
prospects
controlled
material
design
scavenging
biomaterials.
Materials,
Journal Year:
2020,
Volume and Issue:
13(22), P. 5270 - 5270
Published: Nov. 21, 2020
Hydrogels,
three-dimensional
(3D)
polymer
networks,
present
unique
properties,
like
biocompatibility,
biodegradability,
tunable
mechanical
sensitivity
to
various
stimuli,
the
capacity
encapsulate
different
therapeutic
agents,
and
ability
of
controlled
release
drugs.
All
these
characteristics
make
hydrogels
important
candidates
for
diverse
biomedical
applications,
one
them
being
drug
delivery.
The
recent
achievements
as
safe
transport
systems,
with
desired
effects
minimum
side
effects,
brought
outstanding
improvements
in
this
area.
Moreover,
results
from
utilization
target
therapy
strategies
obtained
clinical
trials
are
very
encouraging
future
applications.
In
regard,
review
summarizes
general
concepts
related
types
hydrogel
delivery
their
main
mechanisms,
administration
pathways
at
levels
(oral,
dermal,
ocular,
nasal,
gastrointestinal
tract,
vaginal,
cancer
therapy).
After
a
presentation,
is
focused
on
advances
design,
preparation
applications
innovative
cellulose-based
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(30)
Published: May 18, 2021
Abstract
Flexible
bioelectronics
have
attracted
increasing
research
interests
due
to
their
wide
range
of
potential
applications
in
human
motion
detection,
personal
healthcare
monitoring,
and
medical
diagnosis.
Recently,
design
fabrication
strategies
integrated
with
mussel‐inspired
polydopamine
(PDA)
demonstrated
many
appealing
properties,
which
meet
the
structural
functional
requirements
high‐performance
flexible
bioelectronics.
The
inherent
multiple
reactive
sites
hierarchical
interactions
within
PDA
can
promote
total
electrochemical
activities,
self‐healing,
surface
activation,
biocompatibility
composite
system.
This
review
paper
strives
provide
a
comprehensive
overview
on
this
emerging
area,
including
methodology,
contributions
whole
composites,
various
PDA‐based
current
challenges
future
outlook
field
are
also
extensively
discussed
at
end.
aims
serve
as
guideline
area
new
inspirations
toward
next‐generation
multifunctional
broad
applications.
