Molecules,
Journal Year:
2024,
Volume and Issue:
29(14), P. 3291 - 3291
Published: July 12, 2024
Natural
products
have
always
played
an
important
role
in
pharmacotherapy,
helping
to
control
pathophysiological
processes
associated
with
human
disease.
Thus,
natural
such
as
oleanolic
acid
(OA),
a
pentacyclic
triterpene
that
has
demonstrated
activities
several
disease
models,
are
high
demand.
The
relevant
properties
of
this
compound
motivated
re-searchers
search
for
new
analogues
and
derivatives
using
the
OA
scaffold
which
functional
groups
been
added
or
modifications
realized.
its
shown
be
effective
treatment
inflammatory
processes,
triggered
by
chronic
diseases
bacterial
viral
infections.
also
found
diabetic
disorders,
group
common
endocrine
characterized
hyperglycemia
can
affect
organs,
including
liver
brain.
This
compounds
reported
exhibit
significant
bioactivity
against
cancer
vitro
vivo.
In
review,
we
summarize
bioactive
anti-inflammatory,
anti-bacterial,
antiviral,
anti-diabetic,
hepatoprotective,
neuroprotective,
anticancer
agents.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(9), P. 4469 - 4494
Published: Sept. 9, 2024
Lung
cancer
remains
a
global
health
concern,
demanding
the
development
of
noninvasive,
prompt,
selective,
and
point-of-care
diagnostic
tools.
Correspondingly,
breath
analysis
using
nanobiosensors
has
emerged
as
promising
noninvasive
nose-on-chip
technique
for
early
detection
lung
through
monitoring
diversified
biomarkers
such
volatile
organic
compounds/gases
in
exhaled
breath.
This
comprehensive
review
summarizes
state-of-the-art
breath-based
diagnosis
employing
chemiresistive-module
supported
by
theoretical
findings.
It
unveils
fundamental
mechanisms
biological
basis
biomarker
generation
associated
with
cancer,
technological
advancements,
clinical
implementation
nanobiosensor-based
analysis.
explores
merits,
challenges,
potential
alternate
solutions
implementing
these
settings,
including
standardization,
biocompatibility/toxicity
analysis,
green
sustainable
technologies,
life-cycle
assessment,
scheming
regulatory
modalities.
highlights
nanobiosensors'
role
facilitating
precise,
real-time,
on-site
leading
to
improved
patient
outcomes,
enhanced
management,
remote
personalized
monitoring.
Additionally,
integrating
biosensors
artificial
intelligence,
machine
learning,
Internet-of-things,
bioinformatics,
omics
technologies
is
discussed,
providing
insights
into
prospects
intelligent
sniffing
nanobiosensors.
Overall,
this
consolidates
knowledge
on
breathomic
biosensor-based
screening,
shedding
light
its
significance
applications
advancing
medical
diagnostics
reduce
burden
hospitals
save
human
lives.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 24, 2024
Osteoarthritis
(OA)
is
an
intricate
pathological
condition
that
primarily
affects
the
entire
synovial
joint,
especially
hip,
hand,
and
knee
joints.
This
results
in
inflammation
synovium
osteochondral
injuries,
ultimately
causing
functional
limitations
joint
dysfunction.
The
key
mechanism
responsible
for
maintaining
articular
cartilage
function
chondrocyte
metabolism,
which
involves
energy
generation
through
glycolysis,
oxidative
phosphorylation,
other
metabolic
pathways.
Some
studies
have
shown
chondrocytes
OA
exhibit
increased
glycolytic
activity,
leading
to
elevated
lactate
production
decreased
matrix
synthesis.
In
cartilage,
display
alterations
mitochondrial
such
as
ATP
stress,
can
contribute
deterioration.
Chondrocyte
metabolism
also
anabolic
processes
extracellular
substrate
generation.
During
OA,
undergo
considerable
changes
different
aspects,
homeostasis
Numerous
been
carried
out
provide
tangible
therapies
by
using
various
models
vivo
vitro
targeting
although
there
are
still
certain
limitations.
With
growing
evidence
indicating
essential
role
of
disease
etiology,
this
literature
review
explores
characteristics
presence
both
.
To
insight
into
complex
reprogramming
crucial
during
progression,
we
investigate
dynamic
interaction
between
pathways,
lipid
function.
addition,
highlights
prospective
future
research
directions
novel
approaches
diagnosis
treatment.
Adopting
a
multifaceted
strategy,
our
aims
offer
comprehensive
understanding
intricacies
within
with
ultimate
goal
identifying
therapeutic
targets
capable
modulating
treatment
OA.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
Abstract
Bone
organoids,
in
vitro
models
mimicking
native
bone
structure
and
function,
rely
on
3D
stem
cell
culture
for
self‐organization,
differentiation,
ECM
secretion,
biomineralization,
ultimately
forming
mineralized
collagen
hierarchies.
However,
their
development
is
often
limited
by
the
lack
of
suitable
matrices
with
optimal
mechanical
properties
sustained
growth
differentiation.
To
address
this,
a
dynamic
DNA/Gelatin
methacryloyl
(GelMA)
hydrogel
(CGDE)
developed
to
recapitulate
key
biochemical
features
ECM,
providing
supportive
microenvironment
organoid
formation.
This
dual‐network
engineered
through
hydrogen
bonding
between
DNA
GelMA,
combined
GelMA
network
crosslinking,
resulting
appropriate
strength
enhanced
viscoelasticity.
During
21‐day
culture,
CGDE
facilitates
cellular
migration
promoting
woven
(WBO)
formation
via
intramembranous
ossification.
These
WBOs
exhibit
spatiotemporal
architectures
supporting
mineralization
tissue
remodeling.
In
vivo
studies
demonstrate
that
CGDE‐derived
self‐adaptive
properties,
enabling
rapid
osseointegration
within
4
weeks.
work
highlights
as
robust
scalable
platform
development,
offering
new
insights
into
biology
innovative
strategies
regeneration.
Annals of Hepatology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101777 - 101777
Published: Jan. 1, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD),
now
recognized
as
metabolic
dysfunction-associated
steatotic
(MASLD),
represents
a
significant
and
escalating
global
health
challenge.
Its
prevalence
is
intricately
linked
to
obesity,
insulin
resistance,
other
components
of
the
syndrome.
As
our
comprehension
MASLD
deepens,
it
has
become
evident
that
this
condition
extends
beyond
liver,
embodying
complex,
multi-systemic
with
hepatic
manifestations
mirror
broader
landscape.
This
comprehensive
review
delves
into
critical
interplay
between
gut-liver
axis
oxidative
stress,
elucidating
their
pivotal
roles
in
etiology
progression
MASLD.
Our
analysis
reveals
several
key
findings:
(1)
Bile
acid
dysregulation
can
trigger
stress
through
enhanced
ROS
production
hepatocytes
Kupffer
cells,
leading
mitochondrial
dysfunction
lipid
peroxidation;
(2)
Gut
microbiota
dysbiosis
disrupts
intestinal
barrier
function,
allowing
increased
translocation
endotoxins
like
LPS,
which
activate
inflammatory
pathways
TLR4
signaling
promote
via
NADPH
oxidase
activation;
(3)
The
redox-sensitive
transcription
factors
NF-κB
Nrf2
serve
crucial
mediators
axis,
regulating
responses
orchestrating
antioxidant
defenses;
(4)
Oxidative
stress-induced
damage
function
creates
destructive
feedback
loop,
further
exacerbating
inflammation
progression.
These
findings
highlight
complex
interrelationship
pathogenesis,
suggesting
potential
therapeutic
targets
for
management.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 467 - 467
Published: Jan. 22, 2025
Vanillic
acid
(VA)
is
a
dietary
benzoic
derivative,
flavoring
agent,
and
food
stabilizer.
In
this
study,
the
antioxidant
anti-inflammatory
potential
of
VA
was
explored
in
vitro
ex
vivo
human
immune
cells
non-cellular
models.
neutrophils,
significantly
downregulated
fMLP-induced
oxidative
burst
generation
reactive
oxygen
species
(ROS);
it
also
suppressed
release
pro-inflammatory
cytokines
(TNF-α,
IL-8)
tissue-remodeling
enzyme
elastase-2
(ELA-2)
stimulated
with
LPS
fMLP+cytochalasin
B.
Additionally,
showed
good
biocompatibility
neutrophils
peripheral
blood
mononuclear
(PBMCs)
across
tested
concentrations
1–50
µg/mL.
Furthermore,
at
1–5
μg/mL
enhanced
non-enzymatic
capacity
plasma
(NEAC)
prevented
nitrative
damage
to
proteins
by
protecting
tyrosine
moieties
thiols
from
peroxynitrite.
inhibited
lipid
peroxidation
formation
thiobarbituric
acid-reactive
substances
(at
50
μg/mL)
protein-bound
carbonyls
5–50
peroxynitrite-treated
plasma.
tests,
acted
as
hypochlorous
hydrogen
peroxide
scavenger
protein
glycation,
outperforming
references
Trolox
aminoguanidine.
Along
existing
data
animal
models
studies
on
polyphenol
intake,
these
results
might
support
synergic
role
protection
against
chronic
diseases
related
stress
inflammation.
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 126 - 126
Published: Feb. 9, 2025
Peripheral
nerve
injuries
pose
a
significant
clinical
challenge
due
to
the
complex
biological
processes
involved
in
repair
and
their
limited
regenerative
capacity.
Despite
advances
surgical
techniques,
conventional
treatments,
such
as
autografts,
are
faced
with
limitations
like
donor
site
morbidity
inconsistent
functional
outcomes.
As
such,
there
is
growing
interest
new,
novel,
innovative
strategies
enhance
regeneration.
Tissue
engineering/regenerative
medicine
its
use
of
biomaterials
an
emerging
example
strategy.
Within
realm
tissue
engineering,
functionalized
hydrogels
have
gained
considerable
attention
ability
mimic
extracellular
matrix,
support
cell
growth
differentiation,
even
deliver
bioactive
molecules
that
can
promote
repair.
These
be
engineered
incorporate
factors,
peptides,
stem
cells,
creating
conducive
microenvironment
for
cellular
axonal
Recent
advancements
materials
well
biology
led
development
sophisticated
hydrogel
systems,
not
only
provide
structural
support,
but
also
actively
modulate
inflammation,
recruitment,
stimulate
neurogenesis.
This
review
explores
potential
peripheral
repair,
highlighting
composition,
biofunctionalization,
mechanisms
action.
A
comprehensive
analysis
preclinical
studies
provides
insights
into
efficacy
these
promoting
growth,
neuronal
survival,
regeneration,
and,
ultimately,
recovery.
Thus,
this
aims
illuminate
promise
transformative
tool
field
bridging
gap
between
complexity
feasibility.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3148 - 3148
Published: March 28, 2025
Oxidative
stress
(OS)
and
gut
microbiota
are
crucial
factors
influencing
human
health,
each
playing
a
significant
role
in
the
development
progression
of
chronic
diseases.
This
review
provides
comprehensive
analysis
complex
interplay
between
these
two
factors,
focusing
on
how
an
imbalance
reactive
oxygen
species
(ROS)
antioxidants
leads
to
OS,
disrupting
cellular
homeostasis
contributing
range
conditions,
including
metabolic
disorders,
cardiovascular
diseases,
neurological
cancer.
The
microbiota,
diverse
community
microorganisms
residing
gastrointestinal
tract,
is
essential
for
regulating
immune
responses,
pathways,
overall
health.
Dysbiosis,
composition,
closely
associated
with
inflammation,
dysfunction,
various
highlights
influences
influenced
by
complicating
pathophysiology
many
conditions.
Furthermore,
emerging
evidence
has
identified
extracellular
vesicles
(EVs)
as
critical
facilitators
crosstalk
OS
microbiota.
EVs
also
play
signaling
host
tissues,
modulating
processes.
function
holds
promise
targeted
therapies
aimed
at
restoring
microbial
balance
mitigating
OS.
Personalized
therapeutic
approaches,
probiotics,
antioxidants,
fecal
transplantation-based
strategies,
can
be
used
address
OS-related
diseases
improve
health
outcomes.
Nonetheless,
further
research
needed
study
molecular
mechanisms
underlying
interactions
potential
innovative
interventions
offer
novel
strategies
managing
enhancing