An
electrochemical
redox
C(sp3)-H
arylsulfonylation
of
xanthenes
has
been
developed
using
aryl
diazonium
tetrafluoroborates
and
DABSO
as
the
arylsulfone
source.
This
radical
reaction
proceeds
via
formation
arylsulfonyl
radicals
from
between
DABSO,
followed
by
a
cross-coupling
process.
Notably,
occurs
in
absence
any
catalyst
or
external
oxidant,
providing
efficient
sulfonylation
with
broad
functional
group
compatibility.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(18), P. 10058 - 10086
Published: Jan. 1, 2021
This
tutorial
review
provides
an
overview
of
the
most
recent
developments
in
electrochemical
oxidative
cross-coupling
with
hydrogen
evolution
involving
radicals.
Green Chemistry,
Journal Year:
2021,
Volume and Issue:
23(18), P. 6789 - 6862
Published: Jan. 1, 2021
We
provide
a
review
of
the
progress
cross-dehydrogenative
coupling
reactions
in
constructing
wide
variety
C–C
bonds.
Sustainable
can
be
combined
with
multiple
forms
energy
output.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(19), P. 11269 - 11335
Published: Sept. 26, 2023
Late-stage
functionalization
(LSF)
constitutes
a
powerful
strategy
for
the
assembly
or
diversification
of
novel
molecular
entities
with
improved
physicochemical
biological
activities.
LSF
can
thus
greatly
accelerate
development
medicinally
relevant
compounds,
crop
protecting
agents,
and
functional
materials.
Electrochemical
synthesis
has
emerged
as
an
environmentally
friendly
platform
transformation
organic
compounds.
Over
past
decade,
electrochemical
late-stage
(eLSF)
gained
major
momentum,
which
is
summarized
herein
up
to
February
2023.
Advanced Synthesis & Catalysis,
Journal Year:
2021,
Volume and Issue:
363(7), P. 1810 - 1834
Published: Feb. 16, 2021
Abstract
Transition
metal‐catalysed
processes
have
been
widely
used
for
the
functionalization
of
inert
C−H
bonds.
Strategies
benzylic
position
having
a
relatively
weak
bond
(bond
dissociation
energy∼
80–90
kcal/mol)
differ
from
aliphatic
and
aromatic
positions
with
stronger
The
recent
advances
in
direct
activation
through
generation
C(
sp
3
)
radicals
demonstrated
potential
electrochemistry
photochemistry
as
means
constructing
new
chemical
This
review
will
cover
progress
organic
radical
strategies
employing
sustainable
tools.
In
addition,
mechanistic
details
typical
reactions
included
which,
turn,
help
researchers
to
look
at
this
promising
area
different
perspective
towards
discoveries
often
hidden
opportunities.
magnified
image
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(11), P. 2830 - 2848
Published: Jan. 1, 2023
Recent
advances
in
the
electrochemical
generation
of
1,3-dicarbonyl
radicals
from
C–H
bonds
and
their
mechanistic
insights
synthetic
applications
have
been
summarized.
Green Synthesis and Catalysis,
Journal Year:
2021,
Volume and Issue:
2(2), P. 145 - 155
Published: April 19, 2021
Substituted
pyridines
are
very
important
skeleton
in
natural
products,
agrochemicals
and
pharmaceuticals,
which
not
only
can
be
used
to
synthesis
chiral
ligands
functional
materials
but
also
as
building
blocks
the
construction
of
new
photo-
or
electrochemical
properties.
As
a
result,
much
efforts
have
been
developed
towards
such
compounds.
Given
great
influence
these
methodologies
organic
chemistry,
we
summarize
recent
progress
radical-mediated
decyanative
alkylation
reactions
cyano(hetero)arene
via
photo/electrochemistry
radical
pathway,
C(sp3)-H,
C(sp2)-H,
C–C
C-hetero
bonds
cleavaged
bond
is
formed.
We
discussed
mechanisms
reactions.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(11), P. 2125 - 2130
Published: March 14, 2022
We
report
the
challenging
direct
carbamoylation
or
cyanation
of
benzylic
C(sp3)–H
bonds
with
an
isocyanide
via
electrochemical
process
giving
rise
to
structures
that
are
encountered
in
several
biologically
relevant
compounds
and
drugs.
This
transformation
proceeds
under
mild
conditions
without
need
for
any
external
oxidant
avoids
necessity
start
from
a
prefunctionalized
substrate
deployment
cation
pool
method.
The
anodic
oxidation
position
subsequent
addition
lead
formation
C–C
bond
nitrilium
hydrolyzes
yield
α-aryl
acetamide
derivatives,
whereas
elimination
t-butyl
delivers
acetonitrile
derivatives.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(7), P. 1911 - 1916
Published: Jan. 1, 2022
A
catalyst-free
and
oxidant-free
C–H
arylation
of
xanthenes
thioxanthenes
using
electrochemistry
has
been
developed,
which
affords
a
number
cross-coupling
products
in
moderate
to
good
yields.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(3), P. 928 - 933
Published: Jan. 1, 2023
We
have
developed
a
mild
and
efficient
electrochemical
oxidative
strategy
to
construct
anticancer
alkoxylated
4
H
-3,1-benzoxazines
indolines
without
the
requirement
for
transition-metal
catalyst
an
external
oxidant.
