Chemistry - An Asian Journal,
Journal Year:
2021,
Volume and Issue:
16(17), P. 2431 - 2434
Published: July 19, 2021
Abstract
We
describe
a
catalytic
method
for
the
synthesis
of
variety
functionalized
aliphatic
acid
esters
using
silylperoxyacetals,
which
are
versatile
alkyl
radical
precursors
with
terminal
ester
moiety.
In
presence
an
appropriate
transition‐metal
catalyst,
in
situ
generation
radicals
and
subsequent
bond‐forming
process
proceeds
smoothly
to
afford
synthetically
valuable
derivatives.
The
present
can
be
applied
efficient
pharmaceutically
important
1,1‐diarylalkane
motif.
addition,
novel
strategy
structurally
diverse
hydroxy
derivatives
via
C−O
bond
formation
that
utilizes
TEMPO
has
been
developed.
Chemical Communications,
Journal Year:
2021,
Volume and Issue:
58(6), P. 730 - 746
Published: Dec. 8, 2021
This
article
provides
a
comprehensive
perspective
on
three-component
1,2-dicarbofunctionalization
of
alkenes
involving
alkyl
radicals,
which
generated
from
structurally
diverse
electrophilic
and
nucleophilic
precursors
under
mild
conditions.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(19), P. 5220 - 5225
Published: Jan. 1, 2023
An
efficient
alkoxyl
radical-triggered
ring
expansion/cross-coupling
cascade
was
developed
under
cheap
metal
catalysis.
Through
the
metal-catalyzed
radical
relay
strategy,
a
wide
range
of
medium-sized
lactones
(9-11
membered)
and
macrolactones
(12,
13,
15,
18,
19-membered)
were
constructed
in
moderate
to
good
yields,
along
with
diverse
functional
groups
including
CN,
N3,
SCN,
X
installed
concurrently.
Density
theory
(DFT)
calculations
revealed
that
reductive
elimination
cycloalkyl-Cu(iii)
species
is
more
favorable
reaction
pathway
for
cross-coupling
step.
Based
on
results
experiments
DFT,
Cu(i)/Cu(ii)/Cu(iii)
catalytic
cycle
proposed
this
tandem
reaction.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(32)
Published: June 15, 2023
We
disclose
a
Ni-catalyzed
regioselective
dialkylation
reaction
of
alkenylarenes
with
α-halocarbonyls
and
alkylzinc
reagents.
The
produces
γ-arylated
alkanecarbonyl
compounds
the
generation
two
new
C(sp
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(8), P. 1336 - 1341
Published: Feb. 23, 2023
A
concise
Fe-catalyzed
alkylazidation
of
α-trifluoromethylalkenes
via
a
C–C
bond
cleavage/radical
addition/azidation
cascade
is
described.
This
protocol
features
broad
substrate
scope,
excellent
functional
group
compatibility,
and
the
ability
to
be
performed
on
gram
scale,
thus
offering
practical
step-economic
approach
synthetically
useful
tertiary
α-trifluoromethyl
azides.
Green Chemistry,
Journal Year:
2021,
Volume and Issue:
23(23), P. 9549 - 9553
Published: Jan. 1, 2021
A
metal
free,
visible-light
driven
C–H
ketoalkylation
of
glycine
derivatives
and
peptides
with
cycloalkyl
hydroperoxides
is
presented.
This
protocol
provides
diverse
unnatural
amino
acids
bearing
a
distal
carbonyl
group
in
moderate
to
good
yields.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(30), P. 5563 - 5568
Published: July 21, 2023
A
redox-neutral
copper-catalyzed
cascade
reaction
involving
alkoxyl
radical-mediated
ring
expansion/1,4-difunctionalization
of
1,3-enynes
was
developed,
offering
a
straightforward
approach
to
the
tetra-substituted
allenes
with
macrolactone,
CN,
and
CF3
functional
groups.
Remarkably,
incorporation
NH2
group
onto
1,3-enyne
moiety
enabled
further
cyclization
give
unique
scaffold
containing
lactone
an
indole
moiety.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(16), P. 3043 - 3047
Published: April 18, 2022
We
report
a
novel
Ru-catalyzed
regioselective
alkylarylation
of
vinylarenes
with
alkyl
halides
and
arenes
via
meta-C(sp2)-H
bond
functionalization
to
construct
1,1-diarylalkanes
that
generally
show
bioactivity.
In
this
transformation,
wide
spectrum
primary,
secondary,
tertiary
electronically
varied
was
well-tolerated.
This
reaction
is
characterized
by
its
exquisite
regioselectivity
vinylarenes,
unique
selectivity,
redox-neutral
conditions.
The
mechanism
presented
supported
radical
probes
kinetic
isotope
effect
studies.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1478 - 1488
Published: Jan. 17, 2025
Herein,
we
present
a
copper-catalyzed,
three-component
intermolecular
1,4-alkylarylation
of
1,3-enynes
with
ethers
and
aryl
boronic
acids.
This
method,
driven
by
α-C(sp3)-H
functionalization
the
oxygen
atom
in
ethers,
regioselectively
produces
various
tetrasubstituted
allenes
from
simple,
readily
available
precursors.
Key
features
include
mild
reaction
conditions
simple
catalytic
system.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(23), P. 4329 - 4334
Published: June 1, 2023
An
inexpensive
iron-catalyzed
alkoxyl
radical-induced
C–C
bond
cleavage/gem-difluoroalkylation
cascade
is
presented.
Regulated
by
the
structure
of
radical
precursors,
fluorinated
distal
diketones
were
synthesized
through
a
ring-opening
strategy
and
difluoroalkylated
medium-sized
lactones
macrolactones
constructed
via
ring-expansion
strategy.
Both
protocols
proceeded
under
mild
redox
neutral
conditions
with
broad
substrate
scope
good
functional
group
compatibility.
