ChemistrySelect,
Journal Year:
2022,
Volume and Issue:
7(5)
Published: Feb. 1, 2022
Abstract
Green
chemistry
is
the
basis
for
fast‐growing,
eco‐friendly,
alternative
sustainable
technologies
development
of
chemical
products
without
use
or
generation
hazardous
catalysts.
The
role
naturally
occurring
fruit
juice
as
a
catalyst
solvent
in
organic
synthesis
has
gained
focused
interest
across
globe.
Lemon
juice‐mediated
been
widely
explored
recently
highly
significant,
selective
and
biocatalyst
synthesis.
This
review
presents
recent
developments
on
lemon‐juice
mediated
transformations
their
application
to
synthesize
molecules
building
blocks
pharmaceutical
interest.
We
believe
this
article
will
be
researchers
both
academic
industrial
settings
developing
novel
pharmacophores
from
green
principles
perspective.
Chemistry - A European Journal,
Journal Year:
2021,
Volume and Issue:
27(52), P. 13107 - 13116
Published: June 29, 2021
Abstract
The
use
of
allenes
and
1,3‐dienes
as
chiral
allylmetal
pronucleophiles
in
intermolecular
catalytic
enantioselective
reductive
additions
to
aldehydes,
ketones,
imines,
carbon
dioxide
other
C=X
electrophiles
is
exhaustively
catalogued
together
with
redox‐neutral
hydrogen
auto‐transfer
processes.
Coverage
limited
processes
that
result
both
C−H
C−C
bond
formation.
alkynes
latent
multicomponent
allylations
involving
dienes
not
covered.
As
illustrated
this
review,
the
ability
serve
tractable
non‐metallic
has
evoked
many
useful
transformations
have
no
counterpart
traditional
chemistry.
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(13), P. 4921 - 4927
Published: March 23, 2021
Alkenyl
boronates
add
to
Ir(π-allyl)
intermediates
with
high
enantioselectivity.
A
1,2-metalate
shift
forms
a
second
C–C
bond
and
sets
1,3-stereochemical
relationship.
The
three-component
coupling
provides
tertiary
boronic
esters
that
can
undergo
multiple
additional
functionalizations.
An
extension
trisubstituted
olefins
three
contiguous
stereocenters.
Molecules,
Journal Year:
2021,
Volume and Issue:
27(1), P. 132 - 132
Published: Dec. 27, 2021
In
this
review,
we
comprehensively
describe
catalyzed
multicomponent
reactions
(MCRs)
and
the
multiple
roles
of
catalysis
combined
with
key
parameters
to
perform
these
transformations.
Besides
improving
yields
shortening
reaction
times,
is
vital
achieving
greener
protocols
furthering
MCR
field
research.
Considering
that
MCRs
typically
have
two
or
more
possible
pathways
explain
transformation,
essential
for
selecting
a
route
avoiding
byproduct
formation.
Key
parameters,
such
as
temperature,
catalyst
amounts
reagent
quantities,
were
analyzed.
Solvent
effects,
which
are
likely
most
neglected
topic
in
MCRs,
well
their
catalysis,
critically
discussed.
Stereocontrolled
rarely
observed
without
presence
catalytic
system,
also
presented
discussed
review.
Perspectives
on
use
systems
improved
finally
presented.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 28, 2024
1,2-Difunctionalization
of
alkynes
offers
a
straightforward
approach
to
access
polysubstituted
alkenes.
However,
simultaneous
multi-component
cascade
transformations
including
difunctionalization
two
with
both
syn-
and
anti-selectivity
in
one
catalyst
system
is
undeveloped
proves
be
significant
challenge.
Herein,
we
report
Nickel-catalyzed
four-component
reaction
1,3-dienes
using
terminal
alkynes,
aryl
boroxines,
perfluoroalkyl
iodides,
wherein
the
forms
three
new
C-C
bonds
single
vessel
serve
as
modular
strategy
excellent
chemoselectivity,
good
regioselectivity
exclusive
stereoselectivity.
Control
experiments
reveal
plausible
mechanism
DFT
calculations
explain
cause
for
formation
this
unusual
reaction.
Furthermore,
successfully
incorporate
biologically
active
units
into
1,2,3,4-tetrasubstituted
1,3-dienes,
which
greatly
increases
diversity
molecular
scaffolds
brings
more
potential
values
medicinal
chemistry,
synthetic
utility
our
protocol
further
demonstrated
by
late-stage
transformations.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(15), P. 11318 - 11331
Published: July 15, 2024
Catalytic
enantioselective
borylation
reactions
of
unsaturated
bonds
as
powerful
tools
for
the
synthesis
diverse
chiral
organoboron
compounds
have
gained
much
attention
and
wide
applications
in
various
fields.
However,
atroposelective
arylboration
reaction
with
carbon–carbon
triple
1,3-enynes
to
obtain
axially
1,3-dienylboronates
remains
an
elusive
significant
challenge.
Hence,
we
develop
a
cooperative
copper-
palladium-catalyzed
assemble
plentiful
function
enriched
single
step
from
easily
available
1,3-enynes,
B2pin2,
aryl
bromides
high
levels
chemo-,
regio-,
stereo-,
atroposelectivity.
The
mild
conditions
lead
good
functional
group
tolerance,
which
is
proven
by
broad
substrate
scope
late-stage
functionalizations
bioactive
or
drug
molecules.
Moreover,
can
be
scaled
up,
series
further
transformations
achieved.
It
worth
emphasizing
that
several
olefin
catalysts
ligands
axial
chirality
also
synthesized
through
corresponding
elaborations
such
products,
explains
transformative
ability
application
potential
1,3-dienylboronates.
mechanism
experiment
density
theory
(DFT)
calculations
revealed
process
copper
palladium
catalysis,
indicating
chemoselectivity
regioselectivity
boration
are
determined
enyne
insertion
on
copper,
atroposelectivity
controlled
reductive
elimination
center.
Meanwhile,
calculation
demonstrated
distinct
interactions
between
P═O
C═O
groups
Pd
Bpin
center
key
transition
state
formation
products
varying
configurations
while
employing
identical
configuration
ligands.
Organic Chemistry Frontiers,
Journal Year:
2021,
Volume and Issue:
9(3), P. 838 - 852
Published: Nov. 16, 2021
gem
-Diborylalkanes
are
an
important
class
of
organoboron
compounds
as
they
function
a
key
building
block
in
organic
synthesis.
This
review
summarizes
recent
developments
the
enantioselective
synthesis
-diborylalkanes
and
application
asymmetric
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: July 13, 2022
The
magnetic
nanoparticles
of
Fe3O4
were
synthesized
through
a
solid-state
reaction
hydrated
iron
(III)
chloride,
(II)
chloride
and
NaOH,
then
purified
by
calcination
at
high
temperature.
In
order
to
protect
ferrite
from
oxidation
agglomeration,
manufacture
novel
catalytic
system
anchored
copper
on
the
substrate,
was
core-shelled
adding
tetraethyl
orthosilicate.
Next,
prepared
Fe3O4@SiO2
supported
phosphomolybdic
acid
(PMA)
as
second
layer
nanocomposite
80
°C
in
30
h.
Eventually,
new
Fe3O4@SiO2-PMA-Cu
successfully
solution
solid
potassium
borohydride.
structure
nanocatalyst
acknowledged
different
techniques
such
EDS,
VSM,
XRD,
TEM,
FT-IR,
XPS,
TGA,
BET
FESEM.
synthesis
β-thiolo/benzyl-1,2,3-triazoles
various
thiiranes,
terminal
alkynes
sodium
azide
catalyzed
aqueous
medium.
obtain
optimum
condition,
effects
time,
temperature,
catalyst
amount
solvent
gauged.
recycled
used
for
several
consecutive
runs
without
any
loss
activity.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 20, 2022
Chiral
organoborons
are
of
great
value
in
asymmetric
synthesis,
functional
materials,
and
medicinal
chemistry.
The
development
chiral
bis(boryl)
alkanes,
especially
optically
enriched
1,1-diboron
compounds,
has
been
greatly
inhibited
by
the
lack
direct
synthetic
protocols.
Therefore,
it
is
very
challenging
to
develop
a
simple
effective
strategy
obtain
1,1-diborylalkanes.
Herein,
we
an
enantioselective
copper-catalyzed
cascade
double
hydroboration
terminal
alkynes
highly
enantioenriched
gem-diborylalkanes
were
readily
obtained.
Our
uses
two
different
boranes
construct
valuable
gem-bis(boryl)
alkanes
with
one
catalytic
ligand
pattern,
which
represents
simplest
most
straightforward
for
constructing
such
gem-diborons.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(7), P. 2021 - 2025
Published: Jan. 1, 2022
A
palladium
catalyzed
enantioselective
Heck/borylation
reaction
of
alkene-tethered
aryl
iodides
was
realized,
delivering
a
variety
2,3-dihydrobenzofuranyl
boronic
esters
in
high
yield
with
excellent
enantioselectivity.
