Sensors and Actuators B Chemical, Journal Year: 2021, Volume and Issue: 348, P. 130695 - 130695
Published: Sept. 1, 2021
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 450, P. 214232 - 214232
Published: Oct. 8, 2021
Language: Английский
Citations
161
International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 3937 - 3999
Published: June 1, 2021
Abstract: Surfactants, whose existence has been recognized as early 2800 BC, have had a long history with the development of human civilization. With rapid nanotechnology in latter half 20th century, breakthroughs nanomedicine and food using nanoparticles remarkable, new applications developed. The technology surfactant-coated nanoparticles, which provides functions to for use fields nanotechnology, is attracting lot attention basic research industry. This review systematically describes these “surfactant-coated nanoparticles” through various sections order: 1) surfactants, 2) application 3) nanomedicine, 4) nanotechnology. Furthermore, current progress problems recent reports discussed. Keywords: drug delivery system, targeting, science, packaging, nonionic safety assessment
Language: Английский
Citations
133
Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)
Published: Dec. 16, 2021
Abstract Despite the exciting breakthroughs in medical technology, cancer still accounts for one of principle triggers death and conventional therapeutic modalities often fail to attain an effective cure. Recently, nanobiotechnology has made huge advancement therapy with gigantic application potential because their ability achieving precise controlled drug release, elevating solubility reducing adverse effects. Carbon nanotubes (CNTs), most promising carbon-related nanomaterials, have already achieved much success biomedical field. Due excellent optical property, thermal electronic conductivity, easy functionalization high loading capacity, CNTs can be applied a multifunctional way treatment diagnosis. In this review, we will give overview recent progress CNT-based delivery systems theranostics, which emphasizes targetability intracellular components tumor cells extracellular elements microenvironment. Moreover, detailed introduction on how penetrate inside reach sites action achieve effects, as well diagnostic applications highlighted. Graphic
Language: Английский
Citations
119
Experimental Hematology and Oncology, Journal Year: 2022, Volume and Issue: 11(1)
Published: Oct. 19, 2022
Abstract The tripartite-motif (TRIM) family represents one of the largest classes putative single protein RING-finger E3 ubiquitin ligases. TRIM is involved in a variety cellular signaling transductions and biological processes. also contributes to cancer initiation, progress, therapy resistance, exhibiting oncogenic tumor-suppressive functions different human types. Moreover, members have great potential serve as biomarkers for diagnosis prognosis. In this review, we focus on specific mechanisms participation tumorigenesis, development including interacting with dysregulated pathways such JAK/STAT, PI3K/AKT, TGF-β, NF-κB, Wnt/β-catenin, p53 hub. addition, many studies demonstrated that are related tumor resistance; modulate epithelial–mesenchymal transition (EMT) process, guarantee acquisition stem cells (CSCs) phenotype. end, havediscussed therapeutic targets.
Language: Английский
Citations
88
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 10920 - 10989
Published: Sept. 15, 2023
Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation
Language: Английский
Citations
81
Cancer Communications, Journal Year: 2024, Volume and Issue: 44(4), P. 469 - 490
Published: March 21, 2024
Abstract Background Chemoresistance is a major cause of treatment failure in gastric cancer (GC). Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) an N6‐methyladenosine (m 6 A)‐binding protein involved variety cancers. However, whether m A modification and hnRNPA2B1 play role GC chemoresistance largely unknown. In this study, we aimed to investigate the downstream mechanism chemoresistance. Methods The expression among public datasets were analyzed validated by quantitative PCR (qPCR), Western blotting, immunofluorescence, immunohistochemical staining. biological functions investigated both vitro vivo. RNA sequencing, methylated immunoprecipitation, stability assay performed assess association between binding RNA. maintenance stemness was evaluated bioinformatic analysis, qPCR, sphere formation assays. patterns regulators specimens from patients who received adjuvant chemotherapy RNAscope multiplex immunohistochemistry. Results Elevated found cells tissues, especially multidrug‐resistant (MDR) cell lines. associated with poor outcomes patients, those 5‐fluorouracil treatment. Silencing effectively sensitized inhibiting proliferation inducing apoptosis Mechanically, interacted stabilized long noncoding NEAT1 A‐dependent manner. Furthermore, worked together enhance properties via Wnt/β‐catenin signaling pathway. clinical subjected chemotherapy, levels hnRNPA2B1, NEAT1, CD133, CD44 markedly elevated non‐responders compared responders. Conclusion Our findings indicated that interacts stabilizes lncRNA which contribute property pathway exacerbate GC.
Language: Английский
Citations
20
Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(35), P. 14115 - 14124
Published: Aug. 10, 2021
Breast cancer consists of heterogenic subpopulations, which determine the prognosis and response to chemotherapy. Among these a very limited number cells are particularly problematic. These cells, known as breast stem (BCSCs), thought responsible for metastasis recurrence. They thus major contributor unfavorable outcomes seen many patients. BCSCs more prevalent in hypoxic niche. This is an oxygen-deprived environment that considered crucial their proliferation, stemness, self-renewal but also one makes highly refractory traditional chemotherapeutic regimens. Here we report small molecule construct, AzCDF, allows therapeutic targeting effective normally tumor environments. A related system, AzNap, has been developed permits CSC imaging. Several design elements incorporated into including CAIX inhibitor acetazolamide (Az) promote localization MDA-MB-231 CSCs, dimethylnitrothiophene subunit hypoxia trigger, 3,4-difluorobenzylidene curcumin (CDF) readily released payload. AzCDF serve hypoxia-liable molecular platform targets selectively decreases migration, retards growth, lowers tumorigenesis rates evidenced by combination vitro vivo studies. To best our knowledge, this first time CSC-targeting shown prevent animal model.
Language: Английский
Citations
80
Cancer Letters, Journal Year: 2021, Volume and Issue: 507, P. 55 - 69
Published: March 18, 2021
The tumor microenvironment has been recently reported to play a pivotal role in sustaining cells survival and protecting them from immunotherapy chemotherapy-induced death. It remains largely unknown how the specific signaling pathway exerts head neck squamous cell carcinoma though previous studies have elucidated regulatory mechanisms involve immune microenvironment, stromal cells, angiogenesis cancer stem cell. These components are responsible for progression as well anti-cancer therapy resistance, leading rapid growth treatment failure. In this review, we focus on discussing interaction between surrounding better understanding of ineffectiveness its underlying molecular mechanisms.
Language: Английский
Citations
76
Experimental Hematology and Oncology, Journal Year: 2022, Volume and Issue: 11(1)
Published: Nov. 11, 2022
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but also participates the development and progression of cancer. In recent decades, extensive efforts have been made to decipher role EpCAM cancers. Great advances achieved elucidating its structure, molecular functions, pathophysiological mechanisms, clinical applications. Beyond well-recognized as a biomarker cancer stem cells (CSCs) or circulating tumor (CTCs), exhibits novel promising value targeted therapy. At same time, roles are found be highly context-dependent even contradictory some cases. The versatile functional modules communication with other signaling pathways complicate study this molecule. review, we start from structure focus on pathways. impacts biology cancers up-to-date applications introduced summarized, aiming shed light translational prospects EpCAM.
Language: Английский
Citations
57
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 391 - 410
Published: Dec. 6, 2022
Language: Английский
Citations
51