Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(28)
Published: April 30, 2024
Abstract
Fluorescence
imaging‐guided
photodynamic
therapy
(FIG‐PDT)
holds
promise
for
cancer
treatment,
yet
challenges
persist
in
poor
imaging
quality,
phototoxicity,
and
insufficient
anti‐tumor
effect.
Herein,
a
novel
nanoplatform,
LipoHPM,
designed
to
address
these
challenges,
is
reported.
This
approach
employs
an
acid‐sensitive
amine
linker
connect
biotin‐modified
hydrophilic
polymer
(
Biotin
PEG)
with
new
hydrophobic
photosensitizer
(MBA),
forming
OFF‐state
P
EG‐
M
BA
(PM)
micelles
via
aggregation‐caused
quenching
(ACQ)
These
are
then
co‐loaded
the
tumor
penetration
enhancer
hydralazine
H
DZ)
into
pH‐sensitive
liposomes
(Lipo
HPM
).
Leveraging
ACQ
effect,
LipoHPM
silent
both
fluorescence
reactive
oxygen
species
(ROS)
generation
during
blood
circulation
but
restores
properties
upon
disassembly.
Following
intravenous
injection
tumor‐bearing
mice,
actively
targets
cells
overexpressing
biotin‐receptors,
contributing
enhanced
accumulation.
Upon
cellular
internalization,
disassembles
within
lysosomes,
releasing
HDZ
enhance
inhibit
metastasis.
Concurrently,
activate
boost
production
of
type‐I
type‐II
ROS
eradication.
Therefore,
smart
synergistically
integrates
near‐infrared
emission,
activatable
imaging,
robust
generation,
efficient
anti‐metastasis
activity,
successfully
overcoming
limitations
conventional
photosensitizers
establishing
itself
as
promising
nanoplatform
potent
FIG‐PDT
applications.
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: May 9, 2024
Abstract
The
escalating
global
challenge
of
antimicrobial
resistance
demands
innovative
approaches.
This
review
delves
into
the
current
status
and
future
prospects
bioengineered
metallic
nanoparticles
derived
from
natural
sources
as
potent
agents.
unique
attributes
abundance
resources
have
sparked
a
burgeoning
field
research
in
combating
microbial
infections.
A
systematic
literature
was
conducted,
encompassing
wide
range
studies
investigating
synthesis,
characterization,
mechanisms
nanoparticles.
Databases
such
PubMed,
Scopus,
Web
Science,
ScienceDirect,
Springer,
Taylor
&
Francis
online
OpenAthen
were
extensively
searched
to
compile
comprehensive
overview
topic.
synthesis
methods,
including
green
sustainable
approaches,
examined,
diverse
biological
used
nanoparticle
fabrication.
amalgamation
products
has
yielded
promising
Their
multifaceted
mechanisms,
membrane
disruption,
oxidative
stress
induction,
enzyme
inhibition,
render
them
effective
against
various
pathogens,
drug-resistant
strains.
Moreover,
potential
for
targeted
drug
delivery
systems
using
these
opened
new
avenues
personalized
medicine.
Bioengineered
represent
dynamic
frontier
battle
underscores
their
remarkable
efficacy
action.
Future
are
bright,
with
opportunities
scalability
cost-effectiveness
through
methods.
However,
addressing
toxicity,
regulatory
hurdles,
environmental
considerations
remains
crucial.
In
conclusion,
this
highlights
evolving
landscape
nanoparticles,
offering
valuable
insights
revolutionize
therapy
future.
Graphical
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Sept. 17, 2024
Nanocarriers
(NCs)
play
a
crucial
role
in
delivering
theranostic
agents
to
tumors,
making
them
pivotal
focus
of
research.
However,
the
persistently
low
delivery
efficiency
engineered
NCs
has
been
significant
challenge
advancement
nanomedicine,
stirring
considerable
debate.
Transvascular
transport
is
critical
pathway
for
NC
from
vessels
yet
comprehensive
understanding
interactions
between
and
vascular
systems
remains
elusive.
In
recent
years,
efforts
have
invested
elucidating
transvascular
mechanisms
NCs,
leading
promising
advancements
tumor
theranostics.
this
context,
we
highlight
various
mechanisms,
including
enhanced
permeability
retention
effect,
cooperative
immune-driven
active
transcytosis,
cell/bacteria-mediated
delivery.
Furthermore,
explore
corresponding
strategies
aimed
at
enhancing
efficient
These
approaches
offer
intriguing
solutions
spanning
physicochemical,
biological,
pharmacological
domains
improve
therapeutic
outcomes.
Additionally,
propose
forward-looking
framework
that
relies
on
advanced
tumor/vessel
models,
high-throughput
libraries,
nano-bio
interaction
datasets,
artificial
intelligence,
which
aims
guide
design
next-generation
carriers
implementation
optimized
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(23)
Published: Feb. 15, 2024
Abstract
High‐performance
theranostic
systems
are
of
paramount
importance
for
achieving
precise
image‐guided
cancer
immunotherapy.
Here,
a
novel
nanoplatform
is
presented
that
integrates
aggregation‐induced
emission
luminogen
(AIEgen)
with
prussian
blue
(PB)
nanocatalyzer
robust
The
AIEgen
dimethylamine
substitution
demonstrates
compelling
near‐infrared
(NIR)
light‐induced
photothermal
conversion
and
photodynamic
therapy
(PDT)
capabilities.
By
incorporating
into
porous
PBNPs,
further
enveloped
within
M1
macrophage
membrane,
tumor‐specific
nanoagent
constructed.
This
strategic
integration
effectively
constrains
the
molecular
motion
AIEgen,
leading
to
amplified
NIR‐II
fluorescence
brightness
PDT
attributes.
Moreover,
PBNPs
can
catalyze
tumor‐overexpressed
H
2
O
generate
oxygen
boost
efficacy,
PB's
NIR
absorption
also
intensifies
photoacoustic
imaging
effect.
provides
comprehensive
information
photoimmunotherapy
in
orthotopic
breast
cancer‐bearing
mice.
Leveraging
its
potent
immunogenic
cell
death
effect,
not
only
significantly
inhibits
growth,
but
generates
whole‐cell
therapeutic
vaccine
protect
mice
from
tumor
rechallenge.
In
highly
malignant
post‐surgery
models,
enables
both
accurate
identification
residual
tumors
efficient
inhibition
postoperative
recurrence
pulmonary
metastasis.
study
will
offer
valuable
insights
creating
efficacious
multifaceted
protocols.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Metal-organic
frameworks
(MOFs)
have
played
a
pivotal
role
as
rapid
and
effective
luminescent
sensing
materials.
Numerous
MOFs
with
diverse
characteristics
been
meticulously
designed
for
target
analytes.
Previous
studies
highlighted
the
factors
of
spectral
characteristics,
energy
levels,
interaction
forces,
sensor
stabilities
performance
in
response
to
specific
analyte.
This
conventional
"point-to-point"
approach
necessitates
matching
materials
Herein,
we
develop
modular
MOF-based
platform
by
using
mixed-ligand
strategy.
A
MOF
Eu-FDA
2,5-furandicarboxylic
acid
can
serve
foundational
platform,
partial
replacement
nine
distinct
hexacyclic
isophthalic
acids
modules,
respectively,
specifically
accommodate
different
analytes
particular
structures
properties.
substitution
has
confirmed
through
single-crystal
X-ray
diffraction.
Confronted
possessing
structural
or
property
derivatives
enhance
capability
achieve
heightened
sensitivity.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101583 - 101583
Published: Feb. 16, 2025
The
application
of
Nanocarriers
(NCs)
provides
a
promising
strategy
to
solve
the
problems
faced
by
traditional
chemotherapy
drugs,
like
imprecise
delivery,
poor
bioavailability,
high
dose
requirement,
and
tendency
develop
multidrug
resistance.
With
protection
NCs,
drugs
can
reach
lesion
site
then
release
accurately
completely.
Although
some
reviews
have
summarized
biological
applications
little
attention
has
been
given
advantages
disadvantages
analyzing
organic,
inorganic,
hybrid
NCs
separately
for
targeted
therapy
identifying
means
further
improve
targeting
ability.
First,
in
this
review,
we
emphasize
three
factors
that
marked
impact
on
therapy:
tumor
microenvironment
(TME),
different
administration
modalities
(intravenous,
oral,
intracavitary
administration),
pathways
(passive
active).
Second,
systematic
examination
polymeric
dendrimers,
micelles,
liposomes,
mesoporous
silica
gold
quantum
dots,
nano
clay,
core-shell
MOFs
are
reviewed.
Further,
propose
ways
efficiency
therapy,
including
regulating
size,
shape,
surface
properties
NCs.
