Review of application of the I₂ and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(9), P. 2665 - 2692

Published: Jan. 1, 2024

The synthesis of small molecules and complex scaffolds is one the most important topics in organic synthesis.

Language: Английский

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The green chemistry paradigm in modern organic synthesis

Russian Chemical Reviews, Journal Year: 2023, Volume and Issue: 92(12), P. RCR5104 - RCR5104

Published: Dec. 1, 2023

After the appearance of green chemistry concept, which was introduced in vocabulary early 1990s, its main statements have been continuously developed and modified. Currently, there are 10–12 cornerstones that should form basis for an ideal chemical process. This review analyzes accumulated experience achievements towards design products processes reduce or eliminate use generation hazardous substances. The presents views leading Russian scientists specializing various fields this subject, including homogeneous heterogeneous catalysis, fine basic organic synthesis, electrochemistry, polymer chemistry, based on bio-renewable feedstocks energetic compounds materials. A new approach to quantitative evaluation environmental friendliness by authors is described. <br> bibliography includes 1761.

Language: Английский

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Metal-free photoinduced hydrogen atom transfer assisted C(sp³)–H thioarylation

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(9), P. 3431 - 3436

Published: Jan. 1, 2023

A mild metal-free approach for C(sp 3 )–H thioarylation of organic building blocks.

Language: Английский

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Remote site-selective arene C–H functionalization enabled by N-heterocyclic carbene organocatalysis

Nature Catalysis, Journal Year: 2024, Volume and Issue: 7(8), P. 900 - 911

Published: July 11, 2024

Language: Английский

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Phototriggered Self-Catalyzed Phosphorylation of 3,4-Dihydroquinoxalin-2(1H)-ones with Diarylphosphine Oxides in EtOH

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

A highly effective external photocatalyst- and additive-free method for the phosphorylation of 3,4-dihydroquinoxalin-2(1

Language: Английский

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Thermocontrolled Radical Nucleophilicity vs Radicophilicity in Regiodivergent C–H Functionalization

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

The temperature-dependent switching behavior of the saccharin radical is demonstrated, enabling regiodivergent C3–H and C7–H functionalization quinoxalin-2(1H)-ones. was generated through N–Br bond cleavage in N-bromosaccharin (NBSA) observed to transition between radicophile roles. At −10 °C, it utilized as a radicophile, resulting 100% C3-amination, while at +35 acted radical, leading exclusive C7-bromination. Radical nucleophilicity controlled by temperature modulation.

Language: Английский

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Metal-Free Carbon-Based Nanomaterials: Insights from Synthesis to Applications in Sustainable Catalysis

ACS Sustainable Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 11(41), P. 14841 - 14865

Published: Sept. 15, 2023

The development of cutting-edge catalysts is critical in material science for sustainable development. Though, metals have always been used catalysis enabling essential chemicals, but their use not considered owing to the high cost, toxicity, and poor durability. Nevertheless, modern focus has shifted towards metal free materials due leading role Carbon-based nanomaterials become researchers over last 30 years are either as a catalyst support or metal-free various chemical conversions. They highly anticipated state-of-the-art specific surface area, conductivity, tunable functional groups. This account summarizes strategies proposed by our group design carbon electrochemical sensing, biomass valorization, synthesis value-added chemicals. Also, "metal-free" point-of-care devices fabricated provide affordable healthcare services user end. designed using graphitic nitride, reduced graphene oxide, Janus 2D nanomaterials, ultradispersed diamonds, nanotubes. Their efficacy can be improved building composites with incorporating defects. Finally, we share some knowledge insights regarding current challenges future perspectives this emerging field.

Language: Английский

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Hexafluoroisopropanol-assisted selective intramolecular synthesis of heterocycles by single-electron transfer

Nature Synthesis, Journal Year: 2024, Volume and Issue: 3(8), P. 1021 - 1030

Published: July 1, 2024

Abstract Intramolecular amination of remote aliphatic C–H bonds via hydrogen-atom transfer reactions has become a powerful tool for accessing saturated nitrogen-containing heterocycles. However, the formation six-membered rings or oxa-heterocycles remains formidable challenge Hofmann–Löffler–Freytag reactions. Here we show how by simply combining bench-stable (bis(trifluoroacetoxy)iodo)benzene and hexafluoroisopropanol (HFIP) can switch from well-established mechanism to different versatile reaction pathway that enables selective C( sp 3 )–H bond functionalization. We have exploited facile radical cations single-electron transfer, in presence absence light, synthesize pyrrolidines piperidines, including drug-type molecules, along with O-heterocycles. Experimental computational mechanistic studies support two distinct pathways, depending on electron density substrate, which HFIP plays multifunctional role.

Language: Английский

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Sulfonylation of Pyridyl Phosphonium Salts with Sulfinate Salts in Aqueous Media for the Synthesis of 4-Pyridyl Sulfones via C–P Bond Cleavage

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

A Na

Language: Английский

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An account on selective functionalization of C(sp3)-H bonds by oxidative cross dehydrogenative coupling (CDC) reactions under transition-metal free condition

Sustainable Chemistry and Pharmacy, Journal Year: 2025, Volume and Issue: 44, P. 101955 - 101955

Published: Feb. 26, 2025

Language: Английский

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