European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 19, 2024
Abstract
A
novel
and
highly
efficient
method
for
the
synthesis
of
2,4,6‐triaryl‐1,3,5‐triazines
2,4,6‐trisubstituted
pyrimidines
from
amidines
alcohols
has
been
established.
Using
an
Earth‐abundant
air‐stable
chromium
salt
catalyst
a
phosphine‐free
ligand,
developed
Cr‐catalyzed
acceptorless
dehydrogenative
coupling
provides
1,3,5‐triazines
with
high
yields
good
functional
group
tolerance.
Moreover,
synthetic
value
this
operationally
simple
protocol
was
demonstrated
by
gram‐scale
experiment
linker
to
construct
various
supramolecular
complexes.
Organic Chemistry Frontiers,
Journal Year:
2021,
Volume and Issue:
8(11), P. 2673 - 2709
Published: Jan. 1, 2021
In
this
review,
we
have
summarized
various
aspects
of
homogeneous
and
heterogeneously
catalyzed
recent
advancements
in
the
synthesis
heterocycles
following
ADC
approach.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(13), P. 8351 - 8367
Published: June 21, 2022
Herein,
we
report
a
simple,
phosphine-free,
and
inexpensive
catalytic
system
based
on
manganese(II)
complex
for
synthesizing
different
important
N-heterocycles
such
as
quinolines,
pyrroles,
pyridines
from
amino
alcohols
ketones.
Several
control
experiments,
kinetic
studies,
DFT
calculations
were
carried
out
to
support
the
plausible
reaction
mechanism.
We
also
detected
two
potential
intermediates
in
cycle
using
ESI-MS
analysis.
Based
these
metal-ligand
cooperative
mechanism
was
proposed.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 12596 - 12607
Published: Sept. 26, 2022
We
present
a
convenient
and
efficient
protocol
to
synthesize
quinolines
quinazolines
in
one
pot
under
mild
conditions.
A
variety
of
substituted
were
synthesized
good
excellent
yields
(up
97%
yield)
from
the
dehydrogenative
cyclizations
2-aminoaryl
alcohols
ketones
catalyzed
by
readily
available
Co(OAc)2·4H2O.
This
cobalt
catalytic
system
also
showed
high
activity
reactions
2-aminobenzyl
with
nitriles,
affording
various
quinazoline
derivatives
95%
yield).
The
offers
an
environmentally
benign
approach
for
synthesis
N-heterocycles
employing
earth-abundant
salt
ligand-free
Catalysis Science & Technology,
Journal Year:
2022,
Volume and Issue:
12(18), P. 5695 - 5702
Published: Jan. 1, 2022
The
synthesis
of
N-heterocycles
has
been
considered
an
emerging
area
chemical
research
due
to
their
extensive
utilization
in
pharmaceuticals,
materials
science,
and
natural
product
synthesis.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(43), P. 12625 - 12633
Published: Jan. 1, 2022
Ruthenium-catalyzed
hydrogen
auto-transfer
reactions
for
the
direct
enantioselective
conversion
of
lower
alcohols
to
higher
are
surveyed.
A
brief
historical
perspective
on
ruthenium-catalyzed
transfer
is
given.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(14), P. 2429 - 2437
Published: May 23, 2022
Abstract
The
“borrowing
hydrogen”
(BH)
method
for
C‐alkylation
reactions
using
alcohol
as
alkylating
agents
is
an
important
synthetic
transformation.
In
this
respect,
designing
cheap
and
bench
stable
earth
abundant
metal
catalyst
borrowing
hydrogen
transformation
a
key
challenge
to
be
witnessed.
Herein
we
have
presented
synthesis
of
non‐phosphine,
easily
accessible
SNS−Ni
complexes.
Ni‐catalyst
was
successfully
applied
the
ketone
enolates
α‐alkylated
ketones.
Primary
with
different
functional
groups
various
heteroaromatic
alcohols
are
well
tolerated.
present
system
efficiently
gram
scale
also
green
chemistry
metrics
reaction
were
calculated.
protocol
extended
biologically
quinoline
moieties.
Finally,
control
experiments
deuterium
labelled
suggest
that
proceeds
via
pathway.
magnified
image
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(22), P. 4162 - 4167
Published: May 31, 2023
We
report
a
selective
and
sustainable
synthesis
of
substituted
pyrazoles
via
an
eco-friendly
acceptorless
dehydrogenative
annulation
(ADA)
greener
alcohols,
malononitrile,
various
aromatic
hydrazides
by
newly
synthesized
binuclear
Ru(II)
p-cymene
complexes.
A
discrete
set
complexes
are
fabricated
structurally
characterized
analytical,
spectral,
single-crystal
X-ray
diffraction
methods.
Further,
the
catalytic
effectiveness
is
explored
for
construction
5-amino-4-cyano-N-aroylpyrazoles
(34
examples)
under
mild
conditions
produces
H2O/H2
as
only
byproduct.
sequence
polysubstituted
has
been
constructed
in
62-95%
yield
using
1
mol
%
catalyst
loading.
Probable
intermediates
detected
reaction
have
isolated
confirmed
nuclear
magnetic
resonance
electrospray
ionization
mass
spectrometry
studies.
Expediently,
therapeutically
significant
gout
medicine
"allopurinol"
analogue
derived
successfully
from
5-amino-4-cyano-N-aroylpyrazoles.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2142 - 2164
Published: Jan. 17, 2024
Abstract
N‐Heterocyclic
compounds,
in
particular,
quinolines
and
quinazolines
are
frequently
used
medicinal
chemistry.
Therefore,
the
direct
clean
synthesis
of
these
valuable
scaffolds
has
been
a
great
interest
for
many
years.
2‐Aminobenzyl
alcohols
as
an
alternative
reactant
instead
unstable
expensive
2‐aminobenzaldehydes
can
be
construction
N‐fused
heterocycles
including
quinolines,
quinazolines,
oxazines,
thiazines,
selenazines,
imidazoles,
diazepines,
etc.
In
this
review
article,
we
have
discussed
recent
developments
use
2‐aminobenzyl
diverse
heterocycles.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(9), P. 2613 - 2623
Published: Jan. 1, 2024
A
Ru-catalyzed
selective
hydroacylation
of
acrylonitriles
with
aldehydes
or
alcohols
towards
β-ketonitriles
is
established.
Glutaronitriles
can
be
obtained
through
a
one-step
tandem
and
Michael
addition
acrylonitrile
alcohols.
