Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(31), P. 10709 - 10774

Published: June 16, 2022

Age-related diseases are associated with increased morbidity in the past few decades and cost treatment of these age-related exerts a substantial impact on social health care expenditure. Anti-aging strategies aim to mitigate, delay reverse aging-associated diseases, thereby improving quality life reducing burden pathologies. The natural dietary antioxidant supplementation offers pharmacological therapeutic effects against various disease conditions. Astaxanthin is one such carotenoid superior activity than other carotenoids, as well vitamins C E, additionally, it known exhibit plethora effects. present review summarizes protective molecular mechanisms actions astaxanthin multiple organs Neurodegenerative [Alzheimer's (AD), Parkinson's (PD), Stroke, Multiple Sclerosis (MS), Amyotrophic lateral sclerosis (ALS), Status Epilepticus (SE)], Bone Related Diseases [Osteoarthritis (OA) Osteoporosis], Cancers [Colon cancer, Prostate Breast Lung Cancer], Cardiovascular disorders [Hypertension, Atherosclerosis Myocardial infarction (MI)], Diabetes complications [Diabetic nephropathy (DN), Diabetic neuropathy, retinopathy (DR)], Eye [Age related macular degeneration (AMD), Dry eye (DED), Cataract Uveitis], Gastric Disorders [Gastritis, Colitis, Functional dyspepsia], Kidney [Nephrolithiasis, Renal fibrosis, Ischemia reperfusion (RIR), Acute kidney injury (AKI), hyperuricemia], Liver [Nonalcoholic fatty liver (NAFLD), Alcoholic Disease (AFLD), Hepatic Ischemia-Reperfusion (IR) Injury], Pulmonary [Pulmonary Fibrosis, (ALI), Chronic obstructive pulmonary (COPD)], Muscle (skeletal muscle atrophy), Skin [Atopic dermatitis (ATD), Photoaging, Wound healing]. We have also briefly discussed astaxanthin's reproductive health.

Language: Английский

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Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition

Food & Function, Journal Year: 2022, Volume and Issue: 13(10), P. 5820 - 5837

Published: Jan. 1, 2022

Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has become a global public threat to human health. It well known that Ganoderma lucidum excellent beneficial effects on function lipid metabolism. The object of this study was investigate the hepatoprotective ganoderic acid A (GAA, one main triterpenoids in G. lucidum) against alcohol-induced reveal underlying mechanisms its protective effects. results showed oral administration GAA significantly inhibited abnormal elevation index, serum total triglyceride (TG), cholesterol (TC), low-density lipoprotein (LDL-C), aspartate aminotransferase (AST) alanine (ALT) mice exposed intake, also protected accumulation pathological changes. Besides, oxidative stress ameliorated dietary intervention through decreasing hepatic levels lactate dehydrogenase (LDH) malondialdehyde (MDA), increasing activities catalase (CAT), superoxide dismutase (SOD), (ADH), aldehyde (ALDH), glutathione (GSH). In addition, evidently intestinal microbial disorder markedly abundance Muribaculaceae, Prevotellaceae, Jeotgalicoccus, Bilophila, Family_XIII_UCG_001, Aerococcus, Ruminococcaceae_UCG_005, Harryflintia, Christensenellaceae, Rumonpcpccaceae, Prevotelaceae_UCG_001, Clostridiales_vadinBB60_group, Parasutterella Bifidobacterium, but proportion Lactobacillus, Burkholderia_Caballeroria_Paraburkholderia, Escherichia_Shigella Erysipelatoclostridium. Furthermore, metabolomics based UPLC-QTOF/MS demonstrated had significant regulatory effect composition metabolites especially biomarkers involved metabolic pathways riboflavin metabolism, glycine, serine threonine pyruvate glycolysis/gluconeogenesis, biosynthesis unsaturated fatty acids, synthesis degradation ketone bodies, fructose mannose Moreover, supplementation regulated mRNA metabolism inflammatory response related genes. Conclusively, these findings demonstrate alleviating expected new functional food ingredient for prevention alcoholic injury.

Language: Английский

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Effects of thiacloprid exposure on microbiota–gut–liver axis: Multiomics mechanistic analysis in Japanese quails

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 442, P. 130082 - 130082

Published: Sept. 30, 2022

Language: Английский

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Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 890, P. 164172 - 164172

Published: May 16, 2023

Language: Английский

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Astaxanthin from microalgae: A review on structure, biosynthesis, production strategies and application

Food Research International, Journal Year: 2023, Volume and Issue: 176, P. 113841 - 113841

Published: Dec. 10, 2023

Language: Английский

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Health benefits of astaxanthin and its encapsulation for improving bioavailability: A review

Journal of Agriculture and Food Research, Journal Year: 2023, Volume and Issue: 14, P. 100685 - 100685

Published: June 12, 2023

As a carotenoid originally used as pigment in the aquaculture industry, astaxanthin is gaining interest food, nutritional, and biopharmaceutical sciences recent years due to its great antioxidant anti-inflammatory properties, well health effects on diabetes, cardiovascular diseases, cancer, so on. However, poor chemical stability water solubility make practical applications of human become challenging. Nanoencapsulation considered possible solution tackle such challenges by improving stability, providing controlled release, thus enhancing bioaccessibility bioavailability. In this article, an updated overview chemistry, sources, extraction methods provided. Moreover, studies were introduced then progress preparation various nanoparticles for encapsulation are highlighted. This perspective article aims provide guidance potential structural designs nanoencapsulation functionality.

Language: Английский

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Astaxanthin: An Overview of Its Sources, Extraction Methods, Encapsulation Techniques, Characterization, and Bioavailability

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101869 - 101869

Published: March 1, 2025

Language: Английский

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Pulmonary inflammatory and fibrogenic response induced by graphitized multi-walled carbon nanotube involved in cGAS-STING signaling pathway

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 417, P. 125984 - 125984

Published: May 4, 2021

Language: Английский

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Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 37(8), P. 2033 - 2043

Published: April 21, 2022

Deltamethrin (DLM) is a widely used and highly effective insecticide. DLM exposure harmful to animal human. Quail, as bird model, has been in the field of toxicology. However, there little information available literature about quail cerebrum damage caused by DLM. Here, we investigated effect on neurons. Four groups healthy quails were assigned (10 each group), respectively given 0, 15, 30, 45 mg/kg gavage for 12 weeks. Through measurements cerebrum, it was found that induced obvious histological changes, oxidative stress, neurons apoptosis. To further explore possible molecular mechanisms, performed real-time quantitative PCR detect expression endoplasmic reticulum (ER) stress-related mRNA such glucose regulated protein 78 kD, activating transcription factor 6, inositol requiring enzyme, kinase RNA (PKR)-like ER kinase. In addition, detected ATP content evaluate functional status mitochondria. The study showed significantly increased decreased tissues. These results suggest chronic induces apoptosis via promoting stress mitochondrial dysfunction. Furthermore, our provide novel explanation DLM-induced avian

Language: Английский

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Activation of the GPX4/TLR4 Signaling Pathway Participates in the Alleviation of Selenium Yeast on Deltamethrin-Provoked Cerebrum Injury in Quails

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(5), P. 2946 - 2961

Published: March 5, 2022

Language: Английский

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