Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 356, P. 109875 - 109875

Published: March 3, 2022

Language: Английский

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Poria cocos water-soluble polysaccharide modulates anxiety-like behavior induced by sleep deprivation by regulating the gut dysbiosis, metabolic disorders and TNF-α/NF-κB signaling pathway

Food & Function, Journal Year: 2022, Volume and Issue: 13(12), P. 6648 - 6664

Published: Jan. 1, 2022

Poria cocos (P. cocos) has been traditionally used as folk medicine and functional food in China for more than 2000 years. The water-soluble polysaccharide is the main component of P. decoction. effects mechanisms from (PCWP) were investigated chronic sleep deprivation (CSD)-induced anxiety rats. CSD induced anxiety, gut dysbiosis, inflammatory responses, reduced neurotransmitter levels, whereas PCWP intervention ameliorated anxiety-like behaviors, increased levels 5-hydroxytryptamine, dopamine, norepinephrine, γ-aminobutyric acid hypothalamus, regulated gastrointestinal peptide factors, inhibited tumor necrosis factor (TNF)-α/nuclear (NF)-κB signaling pathway rats with CSD. changes intestinal flora composition determined using 16S rDNA sequencing, indicated that significantly improved species richness diversity adjusted abundance following dysregulated bacteria closer to normal group: Rikenellaceae_RC9_gut_group, Ruminococcus, Prevotellaceae_UCG-001, Prevotellaceae_NK3B31_group, Fusicatenibacter. Metabolomics was analyze fecal samples identify altered metabolites PCWP-treated groups. Thirty-eight PCWP-related four metabolic pathways such sphingolipid metabolism, taurine hypotaurine vitamin B6 glycerophospholipid metabolism explored. results serum metabolomics showed 26 biomarkers changed after compared model group. regulatory enrichment on sphingolipid, phenylalanine, validation activity enzymes involved above pathways. A strong correlation between potential found. Our findings present new evidence supporting effect preventing progression by inhibiting TNF-α/NF-κB pathway, alleviating disorders, ameliorating microflora imbalance.

Language: Английский

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Ganoderma lucidum polysaccharides improve lipid metabolism against high-fat diet-induced dyslipidemia

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 309, P. 116321 - 116321

Published: March 1, 2023

Language: Английский

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Resveratrol Alleviates Liver Fibrosis Induced by Long-Term Inorganic Mercury Exposure through Activating the Sirt1/PGC-1α Signaling Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(28), P. 15985 - 15997

Published: July 3, 2024

Liver disease has become an important risk factor for global health. Resveratrol (Res) is a natural polyphenol which widely found in foods and variety of biological activities. This study investigated the role microbiota-gut-liver axis Res relieving liver fibrosis induced by inorganic mercury exposure. Twenty-eight mice were divided into four groups (n = 7) treated with mercuric chloride and/or 24 weeks, respectively. The results showed that mitigated ileum injury restrained LPS alcohol entering body circulation. Network pharmacological molecular analyses alleviated oxidative stress, metabolism disorders, inflammation, hepatic stellate cell activation liver. In conclusion, alleviates via activating Sirt1/PGC-1α signaling pathway regulating microbial-gut-liver axis, particularly, increasing relative enrichment Bifidobacterium intestinal tract.

Language: Английский

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The role of mitochondrial dynamics imbalance in hexavalent chromium-induced apoptosis and autophagy in rat testis

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 374, P. 110424 - 110424

Published: Feb. 26, 2023

Language: Английский

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