Inhibition of NF-κB signaling unveils novel strategies to overcome drug resistance in cancers

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 73, P. 101042 - 101042

Published: Jan. 4, 2024

Drug resistance in cancer remains a major challenge oncology, impeding the effectiveness of various treatment modalities. The nuclear factor-kappa B (NF-κB) signaling pathway has emerged as critical player development drug cells. This comprehensive review explores intricate relationship between NF-κB and cancer. We delve into molecular mechanisms through which activation contributes to against chemotherapeutic agents, targeted therapies, immunotherapies. Additionally, we discuss potential strategies overcome this by targeting signaling, such small molecule inhibitors combination therapies. Understanding multifaceted interactions is crucial for more effective strategies. By dissecting complex network NF-κB, hope shed light on novel therapeutic approaches that can enhance outcomes, ultimately improving prognosis patients. aims provide overview current state knowledge its role resistance, offering insights may guide future research interventions fight

Language: Английский

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Ferroptosis inhibitors: past, present and future

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Language: Английский

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MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 19, 2022

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women reproductive age. miR-93-5p has been reported to be elevated granulosa cells PCOS patients. However, mechanism by which drives cell (GC) progression remains unclear. Thus, this study focuses on roles and mechanisms GCs PCOS. Methods KGN have similar ovarian physiological characteristics are used function regulatory GCs. In study, were transfected with si-NC, si-miR93-5p, oe-NC oe-miR93-5p. A counting kit-8 assay, flow cytometry western blotting performed observe proliferation apoptosis different groups. Subsequently, levels reactive oxygen species, malondialdehyde, GPX4, SLC7A11 Nrf2, indicators ferroptosis, measured a dihydroethidium fluorescent dye probe, biochemical kit, reverse transcription quantitative polymerase chain reaction. Ultimately, bioinformatic analysis experimental methods examine interaction between NF-κB signaling pathway. Results was upregulated Overexpression promoted ferroptosis cells, while knockdown showed effect. Biological subsequent experiments demonstrated that negatively regulates NF- κB Conclusion promotes GC regulating Silencing protects against dysfunction. Our identified as new molecular target for improving

Language: Английский

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A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 25, 2023

Leonurine refers to the desiccated aerial portion of a plant in Labiatae family. The primary bioactive constituent is an alkaloid, alkaloid (Leo), renowned for its substantial therapeutic efficacy treatment gynecological disorders, addition broad-spectrum antineoplastic capabilities. Over recent years, pharmacodynamic mechanisms Leo have garnered escalating scholarly interest. exhibits anticancer potential by means array mechanisms, encompassing inhibition neoplastic cell proliferation, induction both apoptosis and autophagy, containment oncogenic invasion migration. key signal transduction pathways implicated these processes include Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), Phosphoinositide3-Kinase/Serine/Threonine Protein Kinase (PI3K/AKT), Signal Transducer Activator Transcription 3 (STAT3), Mitogen-Activated Protein/Extracellular Signal-Regulated (MAP/ERK). This paper commences with exploration principal cellular behaviors influenced associated pathways, thereby scrutinizing sequence events. intention offer theoretical reinforcement elucidation more profound underpinning Leo's correlating pharmaceutical development.

Language: Английский

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Natural product-derived ferroptosis mediators

Phytochemistry, Journal Year: 2024, Volume and Issue: 219, P. 114002 - 114002

Published: Jan. 27, 2024

Language: Английский

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Application of natural products in regulating ferroptosis in human diseases

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155384 - 155384

Published: Jan. 28, 2024

Language: Английский

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Novel insights into the protective effects of leonurine against acute kidney injury: Inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 395, P. 111016 - 111016

Published: April 24, 2024

Language: Английский

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The protective effects of icariin against testicular dysfunction in type 1 diabetic mice Via AMPK-mediated Nrf2 activation and NF-κB p65 inhibition

Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155217 - 155217

Published: Nov. 14, 2023

Language: Английский

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Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115728 - 115728

Published: Oct. 19, 2023

Excessive iron intake is detrimental to human health, especially the liver, which main organ for storage. can lead liver injury. The gut-liver axis (GLA) refers bidirectional relationship between gut and its microbiota a combination of signals generated by dietary, genetic environmental factors. disrupts GLA at multiple interconnected levels, including microbiota, barrier function, liver's innate immune system. induces dysbiosis, destroys barriers, promotes exposure derived metabolites, increases pro-inflammatory environment liver. There increasing evidence that excess alters levels microbiota-derived metabolites such as secondary bile acids (BAs), short-chain fatty acids, indoles, trimethylamine N-oxide, play an important role in maintaining homeostasis GLA. In addition chelators, antioxidants, anti-inflammatory agents currently used overload therapy, intervention may be potential target therapy. this paper, we review chronic diseases, regulation GLA, focus on effects It has been suggested probiotics, fecal transfer, farnesoid X receptor agonists, microRNA therapeutic targets overload-induced injury protecting function.

Language: Английский

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Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis

Lipids in Health and Disease, Journal Year: 2023, Volume and Issue: 22(1)

Published: July 8, 2023

Abstract Background Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play nonalcoholic steatohepatitis (NASH). However, the understanding mechanism limited. Herein, our study aimed to explore role HO-1 in NASH ferroptosis. Methods Hepatocyte conditional knockout (HO-1 HEPKO ) C57BL/6J mice were established fed high-fat diet (HFD). Additionally, wild-type either normal or HFD. Hepatic steatosis, inflammation, fibrosis, lipid peroxidation, iron overload assessed. AML12 HepG2 cells used investigate underlying mechanisms vitro. Finally, liver sections from patients clinically validate histopathology Results In mice, HFD caused accumulation, aggravated by . line with vivo results , knockdown upregulated reactive oxygen species cells. reduced GSH SOD levels, was contrast overexpression Furthermore, present revealed that NF-κB signaling pathway associated ferroptosis models. Likewise, these findings consistent patients. Conclusion The current showed could alleviate progression mediating

Language: Английский

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