Advanced Synthesis & Catalysis,
Journal Year:
2021,
Volume and Issue:
364(4), P. 766 - 772
Published: Nov. 24, 2021
Abstract
A
self‐photocatalyzed
sulfonylation/cyclization
of
quinazolinones
containing
unactivated
alkenes
with
various
sulfonyl
chlorides
was
developed.
The
protocol
provides
access
to
radicals
via
energy
transfer
from
the
quinazolinone
skeleton
chloride.
Notably,
transformations
proceeded
without
any
external
photocatalysts,
additives,
or
oxidants,
providing
an
alternative
method
for
fabricating
sulfonylated
compounds.
magnified
image
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(19), P. 2767 - 2770
Published: Jan. 1, 2023
Radical-mediated
photoredox
hydroarylation
reaction
of
unactivated
alkenes
using
thiosulfonate
compounds
as
key
radical
precursors
to
synthesize
pyridyquinazolinone
and
pyrroloquinazolinone
derivatives
is
described.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(10), P. 1683 - 1688
Published: March 8, 2023
A
visible-light-induced
hydrocyclization
of
unactivated
alkenes
was
developed
using
3CzClIPN
as
the
photocatalyst
to
generate
substituted
α-methyldeoxyvasicinones
and
α-methylmackinazolinones
in
moderate
good
yields.
An
intermolecular
hydrogen
atom
transfer
with
THF
source
involved.
Mechanism
studies
indicated
that
intramolecular
addition
situ
formed
aminal
radical
alkene
generated
polycyclic
quinazolinone.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(7), P. 4199 - 4208
Published: Jan. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(5), P. 1862 - 1867
Published: Feb. 19, 2021
A
visible-light-induced
radical
tandem
cyclization/arylation
between
2-amino-1,
4-naphthoquinone
and
N-allyl-2-bromo-2,2-difluoroacetamides
has
been
developed
without
an
external
photocatalyst.
The
transformation
could
be
carried
out
at
room
temperature
gave
a
variety
of
C-3-functionalized
2-amino-1,4-naphthoquinone
derivatives
in
moderate
to
excellent
yields.
Moreover,
mechanistic
studies
revealed
that
the
reaction
is
driven
by
formation
electron
donor–acceptor
(EDA)
complex.
Green Chemistry,
Journal Year:
2021,
Volume and Issue:
23(15), P. 5549 - 5555
Published: Jan. 1, 2021
This
study
demonstrates
a
photo-induced
and
tetrahydrofuran
(THF)-based
radical
strategy
for
the
selective
oxidation
of
alkenes
to
carbonyls
using
O2
as
sole
oxidant
water
solvent.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(7), P. 1319 - 1325
Published: Feb. 23, 2022
Abstract
An
atom
and
step
economy
cascade
trifluoromethylation/cyclization
of
unactivated
alkene
with
Langlois
reagent
as
a
CF
3
source
is
described.
A
variety
polycyclic
quinazolinones
were
successfully
synthesized
in
52–81%
yields
under
transition
metal‐
oxidant‐free
conditions.
The
used
this
strategy
possesses
the
advantages
bench‐stablity,
cost‐effectivity
high‐efficiency.
Additionally,
gram‐scale
reaction,
broad
substrate
scope
good
functional
group
tolerance
demonstrated
synthetic
usefulness
protocol.
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image
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(32), P. 6293 - 6313
Published: Jan. 1, 2022
As
one
of
the
most
important
structural
units
in
pharmaceuticals
and
medicinal
chemistry,
quinazolinone
its
derivatives
exhibit
a
wide
range
biological
pharmacological
activities,
including
anti-inflammatory,
antitubercular,
antiviral,
anticancer
etc.
In
particular,
2,3-fused
quinazolinones
have
attracted
much
attention
because
rings
fused
to
2,3-positions
improve
their
rigidity
planarity.
Their
synthetic
strategies
made
great
advances
recent
years.
Therefore,
this
review
focuses
on
novel
for
synthesis
from
2017
2022,
such
as
difunctionalization
alkenes,
ring-opening
easily
available
small
rings,
dehydrogenative
cross-coupling
reactions,
transition-metal
catalyzed
cyclizations,
cycloadditions,
other
cascade
reactions.
