The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(22), P. 15582 - 15597
Published: Nov. 1, 2022
A
general
visible-light-induced
photocatalyst-/additive-free
strategy
was
developed
for
the
construction
of
various
nitrogen-heterocycles
(42
examples,
up
to
97%
yield)
such
as
γ-lactams,
δ-lactams,
pyrrolidines,
indolones,
quinolinones,
and
fused
polycyclic
structures
at
room
temperature.
The
prominent
features
this
protocol
are
mild
environmentally
friendly
conditions,
broad
substrate
scope,
good
functional
group
tolerance.
Importantly,
reaction
can
be
performed
under
natural
sunlight,
most
sustainable
energy
source
imaginable.
Furthermore,
provides
straightforward
access
a
range
derivatives
through
subsequent
elaboration
xanthate
group.
Chemical Communications,
Journal Year:
2021,
Volume and Issue:
57(49), P. 6050 - 6053
Published: Jan. 1, 2021
A
green
and
efficient
strategy
for
the
synthesis
of
quinazolinone
derivatives
via
photo-induced
decarboxylative
cascade
radical
acylation/cyclization
unactivated
alkenes
has
been
developed
under
oxidant
photocatalyst
free
conditions.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(11), P. 1994 - 1998
Published: March 15, 2023
Herein,
we
report
a
mild
and
practical
protocol
for
the
α-perchloroalkyl
β-heteroarylation
of
alkenes
using
available
chloroform
as
dichloromethyl
source
via
α-amino
radical-mediated
halogen-atom
transfer.
Various
substrates
are
compatible
under
reaction
conditions,
providing
corresponding
products
in
moderate
to
good
yields.
This
strategy
gives
an
efficient
convenient
method
introduction
chloroalkyl
motifs
into
N-heteroarenes.
The
control
experiment
demonstrates
that
radical
generated
situ
is
key
intermediate
transformation.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(21), P. 2958 - 2961
Published: Jan. 1, 2024
Visible-light-driven
EDA
complex-promoted
ring-opening
of
cycloketone
oxime
esters
to
synthesise
various
4-cyanoalkylated
isoquinoline-1,3-diones
with
acryloylbenzamides
was
developed.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(27)
Published: May 21, 2024
Abstract
The
direct
functionalization
of
quinones
has
always
fascinated
research
communities
due
to
their
biological
and
redox
activities
subsequent
application.
Quinone
motifs
play
a
vital
role
as
precursors
for
many
bioactive
compounds
materials;
hence,
ingenious
methodologies
have
been
elaborated
exploring
these
units.
A
significant
part
the
synthetic
strategies
towards
functionalized
achieved
by
installing
substituents
on
hydroquinones,
phenols,
or
quinone
itself
different
oxidative
coupling
reactions
via
radical
pathways
with
without
utilization
metal
catalysts.
simple
C−H
bond
remains
challenging
inherited
electronic
nature
high
dissociation
energy.
This
review
article
summarizes
recent
advancement
made
through
quinones.
Our
primary
focus
will
be
approaches
mechanistic
that
appeared
in
last
two
decades,
along
short
historical
importance
family.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(7), P. 1020 - 1026
Published: March 10, 2023
Abstract
An
operationally
simple
aqueous
phase
three‐component
photochemical
strategy
for
the
alkylation
of
quinoxalin‐2(1
H
)‐ones
with
diethyl
α
‐bromomalonate
and
unactivated
alkenes
in
absence
both
photoredox
catalysts
additive
has
been
developed.
This
reaction
is
driven
by
activity
electron
donor‐acceptor
(EDA)
complexes
formed
‐bromomalonate.
Irradiation
visible
light
triggered
single‐electron
transfer
(SET)
from
to
‐bromomalonate,
inducing
formation
corresponding
alkyl
radical
subsequent
tandem
reaction.
It
provides
an
efficient
way
construct
alkylated
quinoxalinones
small
molecules.
magnified
image
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(7), P. 4947 - 4957
Published: March 18, 2024
A
photoredox/copper-catalyzed
cascade
radical
cyclization/phosphorothiolation
reaction
of
N-allylbromoacetamides
and
P(O)SH
compounds
has
been
established.
broad
range
novel
nonfluorine-
or
difluoro-substituted
2-pyrrolidinones
bearing
the
C(sp3)-SP(O)(OR)2
moiety
can
be
conveniently
constructed
in
moderate
to
good
yields
under
mild
conditions.
Importantly,
most
tested
phosphorothiolated
showed
potent
inhibitory
effects
toward
both
AChE
BChE.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(4), P. 635 - 697
Published: Jan. 13, 2024
Abstract
In
recent
years,
the
interest
to
develop
cyclizations
promoted
by
visible
light
has
been
gaining
a
lot
of
attention
due
its
sustainability
aspect.
this
review,
we
summarize
most
important
advances
in
period
describing
methods
used
generate
different
ring
sizes,
while
focusing
on
mechanistic
details
these
reactions.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(13), P. 2556 - 2561
Published: March 29, 2022
A
visible-light-induced
photocatalyst-free
three-component
radical
cascade
bicyclization
has
been
achieved
to
obtain
diverse
difluoroamidosulfonylated
dihydrobenzofurans
in
moderate
good
yields.
This
protocol
avoids
potential
toxicity
and
the
tedious
removal
procedure
for
photocatalysts
also
features
mild
reaction
conditions
a
functional
group
tolerance.
Moreover,
mechanistic
investigations
reveal
formation
of
charge-transfer
complex
involvement
an
intramolecular
1,5-hydrogen
atom
transfer
process
this
transformation.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(10), P. 3913 - 3918
Published: April 30, 2021
Enabled
by
electron
donor–acceptor
complexes,
a
novel
visible-light-induced
α-amino
C–H
bond
arylation
protocol,
without
photoredox
catalyst,
has
been
disclosed.
The
protocol
does
not
require
any
transition
metal,
oxidant,
or
exclusion
of
oxygen
moisture.
A
direct
irradiation
the
mixture
tertiary
amines
and
benzonitriles
with
visible
light
in
N,N-diethylethanamide
presence
Cs2CO3
afforded
α-arylated
good
to
excellent
yields.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(24), P. 9474 - 9479
Published: Nov. 30, 2021
A
catalyst-free
strategy
for
regioselective
hydroxydifluoroalkylation
of
alkenes
with
alkyl
bromides
was
developed,
affording
a
series
difluoroalkylated
tertiary
alcohols
in
moderate
to
good
yields.
This
photocatalyst-free
protocol
shows
broad
substrate
scope
under
mild
conditions.
Moreover,
mechanistic
studies
revealed
that
newly
identified
electron
donor-acceptor
complex
is
crucial
this
transformation.
