ChemistrySelect,
Journal Year:
2020,
Volume and Issue:
5(35), P. 11067 - 11071
Published: Sept. 17, 2020
Abstract
Biologically
privileged
fused
pyrimidine
spirocycles
were
synthesized
via
a
metal‐free
three‐component
cascade
reaction
utilizing
mercapto/aza
lactam
active
methylene
compounds.
This
rapid
and
efficient
one‐pot
operation
quickly
delivered
seven
different
polycyclic
spirocyclic
scaffolds
such
as
pyranothiazolopyrimidine,
benzothiazolopyranopyrimidine,
pyranotriazolopyrimidine,
benzoimidazolopyranopyrimidine,
spiroindolinepyranothiazolopyrimidine,
spirobenzothiazolopyranopyrimidineindoline,
spirobenzo‐imidazolopyranopyrimidineindoline
at
room
temperature
with
excellent
regio/chemoselectivity.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(2), P. 1447 - 1489
Published: Jan. 1, 2025
We
have
reviewed
the
recently
reported
multicomponent
reactions
(MCRs)
yielding
cyclic
frameworks
in
a
single
pot
from
simple
building
blocks
under
mild
conditions.
These
MCRs
may
prove
to
be
useful
for
drug
discovery
projects.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(17), P. 13235 - 13271
Published: Jan. 1, 2025
The
category
of
bifunctional
building
blocks
overrides
many
others
because
their
fascinating
wide
applicability
in
synthetic
chemistry.
Aryl
glyoxal
is
one
the
key
molecules
used
extensively
heterocyclic
chemistry
to
afford
nearly
all
types
five-
and
six-membered
heterocycles,
which
are
structural
constituents
natural
products.
multicomponent
reaction
a
practical
strategy
utilize
this
wonderful
moiety
with
different
starting
materials
obtain
numerous
diverse
oxygen
heterocycles.
This
review
covers
advancement
aryl
as
prime
equivalent
recent
years
for
synthesis
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(14)
Published: April 1, 2025
Abstract
We
present
a
novel,
efficient,
eco‐friendly
sonochemical
strategy
for
the
synthesis
of
fused
nitrogen
heterocycles
via
Brønsted
acid‐promoted,
one‐pot
multicomponent
reactions
(MCRs).
This
method
involves
rapid
assembly
6‐aminoindazole,
aryl
aldehydes,
and
1,3‐cyclodione
derivatives
(barbituric
acid,
dimedone,
1,3‐dimethyl
barbituric
acid)
under
mild
identical
reaction
conditions.
The
approach
delivers
diverse
range
highly
functionalized
heterocyclic
frameworks,
including
11‐phenyl‐1,6,7,11‐tetrahydro‐8
H
‐pyrazolo[3,4‐
f
]pyrimido[4,5‐
b
]quinoline‐8,10(9
)‐dione,
8,8‐dimethyl‐11‐phenyl‐1,6,7,8,9,11‐hexahydro‐10
]acridin‐10‐one,
7,9‐diphenyl‐1,6,7,9‐tetrahydro‐2′
‐spiro[pyrazolo[3,4‐
]quinoline‐8,5′‐pyrimidine]‐2′,4′,6′(1′
,3′
)‐trione
derivatives.
molecular
structures
these
compounds
were
unambiguously
confirmed
through
1H‐NMR,
13C‐NMR
single‐crystal
X‐ray
diffraction
(SC‐XRD)
analysis.
Additionally,
control
experiments
provided
valuable
mechanistic
insights
into
pathway.
protocol
stands
out
its
efficiency,
high
yields,
broad
functional
group
tolerance,
making
it
versatile
tool
diversity‐oriented
in
modern
chemistry.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(19), P. 14558 - 14586
Published: Jan. 1, 2025
This
review
discusses
the
diverse
applications
of
β-ketonitriles
in
organic
synthesis,
highlighting
protocols
that
generate
various
compounds,
including
cyclic
hydrocarbons,
aromatic
heterocycles,
spirocycles,
and
fused
heterocycles.
ChemistrySelect,
Journal Year:
2021,
Volume and Issue:
6(9), P. 2323 - 2334
Published: March 2, 2021
Abstract
The
synthesis
and
antibacterial
studies
of
polysubstituted
pyrrolo[3,4‐
b
]pyridine
derivatives
have
been
described.
preparation
was
carried
out
by
the
reaction
enamino
imides,
aromatic
aldehydes
malononitrile/ethyl
cyanoacetate
using
10
mol
%
DBU
(1,8‐diazabicyclo[5.4.0]undec‐7‐ene)
in
ethanol
at
78
°C
good
yields.
compounds
were
characterized
standard
spectroscopic
techniques
including
IR,
1
H
&
13
C
NMR
elemental
analysis
also
final
confirmation
done
single
crystal
X‐ray.
activity
all
synthesized
tested
against
two
Gram
positive
(
S.
pneumoniae
MTCC
655
E.
faecalis
439)
three
negative
coli
ATCC
25922,
typhimurium
3224,
P.
aeruginosa
2453)
bacterial
strains.
Most
showed
moderate
to
activity.
Compounds
4
j
l
)
most
potent
displayed
bactericidal
activities
strain
with
MIC
(minimum
inhibitory
concentration)
values
62.5
μg/mL
125.0
respectively.
Growth
kinetic
,
toxicity
human
RBCs
(red
blood
cells)
docking
selected
supported
that
these
inhibit
growth
cells,
non‐toxic
nature
interact
key
amino
residues
DNA
(deoxyribonucleic
acid)
duplex
(PDBID:
1BNA)
drug‐like
properties.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(21), P. 13945 - 13954
Published: Oct. 12, 2022
A
facile
and
efficient
approach
to
the
synthesis
of
1,2,5-trisubstituted
imidazoles
is
developed
via
a
multicomponent
reaction
under
metal-free
catalysis.
Under
Brønsted
acid
catalysis,
desired
products
can
be
obtained
from
readily
available
vinyl
azides,
aromatic
aldehydes,
amines
without
generating
any
toxic
waste.
The
convenient
operations
high
functional
group
compatibility
indicate
that
this
offers
an
attractive
alternative
method
for
imidazole
derivatives.
European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(48)
Published: Dec. 2, 2022
Abstract
Arylformylacetonitriles
are
versatile
and
attractive
synthons
in
organic
synthesis
owing
to
their
high
reactivity.
Among
the
numerous
transformations
involving
arylformylacetonitriles,
multicomponent
reactions
(MCRs)
offer
straightforward
effective
routes
assemble
reactants
into
a
wide
range
of
five‐
six‐membered
heterocyclic
systems
including
pyrrole,
pyrazole,
triazole,
furan,
pyridine,
pyrimidine,
pyran.
This
review
collects
recent
advances
applications
arylformylacetonitriles
MCRs
for
monocyclic
or
polycyclic
heterocycles
published
literature
since
2001.
