Letters in Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
19(8), P. 608 - 615
Published: Jan. 28, 2022
Abstract:
The
aza-Michael
addition
is
an
attractive
methodology
for
synthetic
organic
chemistry
because
the
resulting
β-aminocarbonyl
compounds
are
valuable
building
blocks
synthesis
of
pharmaceutically
useful
compounds.
However,
monoalkylation
aniline
and
its
derivatives
quite
difficult
anilines
poor
nucleophiles
compared
to
monoalkylated
ones.
Since
publication
pioneering
articles
in
1986,
development
microwave-assisted
has
been
remarkable.
Therefore,
we
began
by
investigating
under
microwave
irradiation.
Because
ready
formation
bisalkylated
products,
reaction
between
Michael
acceptors
difficult.
To
overcome
difficulty,
investigated
effect
irradiation
alkylation
with
chalcones
as
acceptors.
Microwave-assisted
proceeded
smoothly
obtain
mainly
adduct.
substitution
effects
both
chalcone
concerning
yield
were
also
studied.
We
supposed
that
dimer
two
produces
a
bulky
environment
around
amino
group,
which
prevents
from
undergoing
second
alkylation.
confirmed
highly
efficient
rapid
method
preparing
using
chalcones.
Beilstein Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
17, P. 819 - 865
Published: April 19, 2021
Microwave-assisted
(MWA)
multicomponent
reactions
(MCRs)
have
successfully
emerged
as
one
of
the
useful
tools
in
synthesis
biologically
relevant
heterocycles.
These
are
strategically
employed
for
generation
a
variety
heterocycles
along
with
multiple
point
diversifications.
Over
last
few
decades
classical
MCRs
such
Ugi,
Biginelli,
etc.
witnessed
enhanced
yield
and
efficiency
microwave
assistance.
The
highlights
MWA-MCRs
high
yields,
reduced
reaction
time,
selectivity,
atom
economy
simpler
purification
techniques,
an
approach
can
accelerate
drug
discovery
process.
present
review
focuses
on
recent
advances
their
mechanistic
insights
over
past
decade
shed
light
its
advantage
conventional
approach.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(9), P. 1171 - 1171
Published: Sept. 4, 2024
Considering
the
complex
pathogenesis
of
Alzheimer's
disease
(AD),
multi-target
ligand
strategy
is
expected
to
provide
superior
effects
for
treatment
neurological
compared
classic
single
target
strategy.
Thus,
one
novel
pyrrole-based
hydrazide
(
Current Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
27(7), P. 559 - 567
Published: April 1, 2023
Abstract:
Heterocycles
are
organic
compounds,
the
most
important
pharmaceutical
skeleton
widely
distributed
in
nature.
Many
of
them
possess
medicinal
as
well
pharmacological
activities.
Pyrroles
well-known
five-member-privileged
scaffolds
with
potential.
Pyrrole
is
component
complex
macrocycles,
including
porphyrins
heme
and
chlorophylls.
Nowadays,
development
microwave-supported
synthetic
strategies
for
such
biologically
relevant
heterocycles
an
objective.
Microwave-induced
pyrrole
synthesis
has
become
environmentally
benign
route
transformation
reduced
reaction
time
high
yields.
This
mini-review
focuses
on
eco-friendly
microwaveinduced
pyrroles,
their
derivatives,
potential
applications,
covering
literature
up
to
2022.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(6), P. 1512 - 1520
Published: Jan. 1, 2023
Indolylated
diarylmethanes
derived
from
microwave-assisted
copper
catalyzed
decarboxylative
reductive
coupling
of
para
-quinone
methides
with
3-indoleacetic
acids
make
spiroindolequinones
rapidly
accessible.
Green Chemistry,
Journal Year:
2021,
Volume and Issue:
24(3), P. 1259 - 1269
Published: Dec. 24, 2021
Microwave-assisted
dithiocarbamation
of
various
imidazoheterocycles
with
in
situ
generated
dithiocarbamates
via
a
water-soluble
Cu(
i
)
catalyst
using
benign
solvent,
enabling
recyclability,
scalability,
less
reaction
time
and
high
yields.
