ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(3), P. 1732 - 1741
Published: Jan. 18, 2022
Utilizing
1,10-phenanthroline-type
bifunctional
ligands,
an
efficient
Cu-catalyzed
intermolecular
site-selective
remote
C–H
amination
using
cyclohexenone
derivatives
and
anilines
was
realized.
The
amide
group
installed
on
the
ligand
played
a
key
role
in
stabilizing
N-centered
radical
generated
situ
to
realize
C–N-directed
formation.
Meanwhile,
useful
catalytic
system
for
γ-C–H
p-aminophenols
γ-aminated
enones
established.
This
economical
practical
approach
oxygen
as
terminal
oxidant
mild
environmentally
friendly.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(5), P. 2343 - 2350
Published: Feb. 1, 2022
Cyclopropane
is
a
prevalent
structural
unit
in
natural
products
and
bioactive
compounds.
While
the
transition
metal-catalyzed
alkene
cyclopropanation
of
functionalized
compounds
such
as
α-diazocarbonyl
derivatives
has
been
well
established
provides
straightforward
access
to
cyclopropanes,
directly
from
more
stable
simpler
methylene
remained
an
unsolved
challenge
despite
highly
desirable
benefits
minimal
prefunctionalization
increased
operational
safety.
Herein
we
report
electrocatalytic
strategy
for
active
compounds,
employing
organic
catalyst.
The
method
shows
broad
substrate
scope
excellent
scalability,
requires
no
metal
catalyst
or
external
chemical
oxidant,
convenient
several
types
cyclopropane-fused
heterocyclic
carbocyclic
Mechanistic
investigations
suggest
that
reactions
proceed
through
radical-polar
crossover
process
form
two
new
carbon-carbon
bonds
nascent
cyclopropane
ring.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(41), P. 7577 - 7582
Published: Oct. 10, 2022
Here
we
report
a
general
C(sp3)–H/C(sp3)–H
dehydrogenative
coupling
strategy
for
the
preparation
of
various
natural
or
unnatural
amino
acids
from
readily
available
glycine
derivatives
and
hydrocarbons
through
combination
SET
HAT
process.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(11), P. 6962 - 6972
Published: May 22, 2023
An
electrochemical
sulfonylation-triggered
cyclization
reaction
of
indole-tethered
terminal
alkynes
with
sulfinates
as
sulfonyl
sources
has
been
developed,
which
affords
exocyclic
alkenyl
tetrahydrocarbazoles
in
good
chemical
yields.
This
features
convenient
operation
and
tolerates
a
wide
scope
substrates
variety
electronically
sterically
diverse
substituents.
Furthermore,
high
E-stereoselectivity
is
observed
for
this
reaction,
provides
an
efficient
method
the
preparation
functionalized
tetrahydrocarbazole
derivatives.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(13), P. 5206 - 5212
Published: Jan. 1, 2023
We
have
developed
a
visible-light
induced
dehydrogenative
[4
+
2]
annulation
of
benzothioamides
and
alkynes
under
aerobic
conditions
to
synthesize
isothiochromenes.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(75), P. 10378 - 10381
Published: Jan. 1, 2024
Here
we
report
a
visible-light
facilitated
radical
addition
strategy
for
the
preparation
of
various
natural
or
unnatural
α-amino
acids
from
readily
available
glycine
derivatives
and
alkenes.
A
key
aspect
in
achieving
this
side
carbon
chain
introduction
reaction,
while
circumventing
well-documented
cyclization
pathway,
was
employment
radical-polar
crossover
under
redox
neutral
conditions.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(11), P. 2249 - 2254
Published: Jan. 1, 2022
A
solvent-
and
additive-free
oxidative
functionalisation
approach
to
prepare
acyl
azoles
from
aldehydes
mediated
by
a
substoichiometric
quantity
of
recyclable
oxoammonium
salt.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(16), P. 10967 - 10981
Published: July 28, 2022
Chemodivergent
synthesis
of
indeno[1,2-b]indoles
and
isoindolo[2,1-a]indoles
from
the
same
starting
materials
involving
radical
cross-dehydrogenative
couplings
have
been
developed.
Mn(OAc)3·2H2O
selectively
promoted
an
intramolecular
C–H/C–H
dehydrogenative
coupling
reaction
to
provide
indeno[1,2-b]indoles,
while
C–H/N–H
could
proceed
via
electrochemistry
deliver
isoindolo[2,1-a]indoles.
Plausible
mechanisms
chemodivergent
reactions
were
proposed.