The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
A
rhodaelectro-catalyzed
double
dehydrogenative
Heck
reaction
of
indole-2-carboxylic
acids
with
alkenes
has
been
developed
for
the
synthesis
pyrano[3,4-
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(11), P. 2830 - 2848
Published: Jan. 1, 2023
Recent
advances
in
the
electrochemical
generation
of
1,3-dicarbonyl
radicals
from
C–H
bonds
and
their
mechanistic
insights
synthetic
applications
have
been
summarized.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(22), P. 3855 - 3860
Published: Oct. 18, 2023
Abstract
A
rhodium(III)‐catalyzed
C−H
activation/[4+1]
annulation
of
2‐aryl‐3
H
‐indoles
and
CF
3
‐substituted
imidoyl
sulfoxonium
ylides
(TFISYs)
has
been
achieved,
producing
a
wide
variety
trifluoroacetimidoyl‐substituted
11
‐isoindolo[2,1‐a]indoles
in
51–86%
yields.
The
cascade
reaction
involves
imidoylmethylation,
tautomerization
AgOAc‐mediated
C−N
bond
formation
sequence.
could
be
scaled
up
to
2
mmol
scale.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(21), P. 15106 - 15117
Published: Oct. 21, 2023
A
metal-free
one-pot
oxidative
cross-dehydrogenation
coupling
reaction
for
the
formation
of
C-N/C-C
bonds
at
C2,3-positions
indoles
with
azoles
and
quinoxalinones
has
been
developed.
The
proposed
method
several
notable
features,
including
catalysis,
use
N-H
free
as
substrates,
ease
operation,
mild
conditions,
compatibility
a
wide
range
substrates.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 4, 2025
Herein,
we
report
a
divergent
synthesis
of
cationic
azatriphenylene
derivatives
using
orthogonal
control
thermal
and
electro-oxidative
pyridination,
which
transforms
the
single
precursor
into
controlled
products
with
perfect
selectivity.
Simultaneously,
two
switchable
reactions
afford
corresponding
pyridinium
salts
different
optical
properties
such
as
aggregation-induced
emission
(AIE)
aggregation-caused
quenching
(ACQ)
effects.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(17), P. 12128 - 12142
Published: Aug. 22, 2024
We
herein
reveal
a
streamlined
synthesis
of
structurally
fused
6-iminoisoindoloindolones
via
meticulously
orchestrated
cascade
reaction.
This
process
seamlessly
intertwines
2-alkynylaniline
and
2-formylbenzonitrile
under
the
catalytic
influence
TMSOTf,
giving
rise
to
these
compounds
in
remarkable
yields
that
stand
as
testament
efficiency
our
approach.
Moreover,
versatility
this
synthetic
strategy
extends
far
beyond
mere
synthesis,
offering
gateway
creation
both
isoindoloindolone
unprecedented
diphenylbenzopyrrolizinoisoquinolinone
derivatives,
thereby
opening
new
horizons
realm
chemical
innovation.
Furthermore,
strategic
elegance
methodology
is
underscored
by
its
potential
for
scale-up
production
applicability
across
diverse
contexts.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(19), P. 14140 - 14155
Published: Sept. 18, 2023
A
radical
sulfonation–ipso-cyclization
cascade
promoted
by
Mn(OAc)3·2H2O
using
functionalized
alkynes
or
alkenes
and
potassium
metabisulfite
(K2S2O5)
is
reported.
total
of
30
spirocyclic
sulfonates
were
synthesized
under
mild
conditions.
We
also
demonstrate
a
modular
synthesis
approach
in
multiple
steps
for
the
preparation
various
azaspiro[4,5]-trienone-based
sulfonamides
sulfonate
esters.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(11), P. 7104 - 7116
Published: May 4, 2023
A
photocatalytic
chemodivergent
reaction
for
the
selectivity
formation
of
C-S
and
C-N
bonds
in
a
controlled
manner
was
proposed.
The
medium,
either
neutral
or
acidic,
is
critical
to
dictate
2-amino-1,3,4-thiadiazoles
1,2,4-triazole-3-thiones
from
isothiocyanates
hydrazones.
This
practical
protocol
achieve
chemoselectivity
under
mild
metal-free
conditions.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
Herein,
a
Mn
catalytic
protocol
has
been
developed
for
the
cycloalkene
ring
expansion
synthesis
of
azaheterocycles,
allowing
broad-substrate-scope
access
to
pyridine
and
isoquinoline
derivatives.
The
initial
monoaddition
an
azidyl
radical
alkene
further
as-generated
C-radical
addition
O