European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(43)
Published: June 27, 2022
Abstract
A
concise
and
efficient
method
was
developed
in
which
sodium
azide
(NaN
3
)
sulfuryl
fluoride
(SO
2
F
were
directly
employed
to
synthesize
diazo
compounds
with
active
methylene
compounds.
variety
of
produced
good
excellent
yields.
This
protocol
avoids
the
use
organosulfonyl
azides,
features
atom
economy
mild
reaction
conditions.
An
alternate
for
synthesis
provided.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(2), P. 613 - 618
Published: Jan. 3, 2022
We
report
a
Cu(II)-catalyzed
C-H
amidation/cyclization
of
azomethine
imines
with
dioxazolones
as
acyl
nitrene
transfer
reagents
under
additive-
and
ligand-free
conditions.
An
array
1,2,4-triazolo[1,5-a]pyridine
derivatives
were
afforded
in
moderate
to
good
yields
excellent
functional
group
tolerance.
In
addition,
scale-up
reaction
photoluminescence
properties
discussed.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(12), P. 2892 - 2897
Published: Jan. 1, 2023
By
utilizing
the
dual
reactivity
function
of
N
-aminopyridinium
ylides,
we
developed
a
direct
[3
+
2]-cycloaddition
ylides
and
ynals
to
build
pyrazolo[1,5-
]pyridine
core
while
introducing
cyano
group.
Catalysts,
Journal Year:
2021,
Volume and Issue:
11(5), P. 620 - 620
Published: May 11, 2021
Isoquinolones
(isoquinolin-1(2H)-ones)
are
one
of
the
important
nitrogen-heterocyclic
compounds
having
versatile
biological
and
physiological
activities,
their
synthetic
methods
have
been
recently
developed
greatly.
This
short
review
illustrates
significant
advances
in
construction
isoquinolone
ring
with
atom-
step-economy,
focusing
on
intermolecular
annulation
protocols
intramolecular
cyclization
presence
a
variety
catalyst
systems.
The
syntheses
isoquinolone-fused
rings
also
included.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(9), P. 2529 - 2533
Published: Jan. 1, 2022
A
transition
metal-
and
oxidant-free
C–C/C–N
annulation
of
azomethine
imines
with
vinylene
carbonate
as
dual
synthons
under
simple
reaction
conditions
is
described
herein.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 17, 2024
Abstract
The
sustainable
preparation
of
N
‐heterocycles
is
one
the
most
active
research
areas
owing
to
their
predominance
as
synthetics
building
blocks
with
extensive
applications
in
organic,
pharmaceutical,
and
material
chemistry
fields.
Among
various
catalytic
protocols,
C−H
bond
functionalization
concomitant
C−N
formation,
so‐called
annulation,
has
become
routes
access
because
it
starts
from
low‐functionalized
materials
generates
a
limited
amount
waste,
all
respecting
concept
atom
economy.
Rhodium
complexes
often
catalyze
these
reactions.
This
review
focuses
on
synthesis
5‐
6‐membered
ring
‐containing
heterocycles
such
indoles,
pyrroles,
indolines,
(iso)quinolinones,
dihydroquinolines,
pyrrolidones
readily
available
starting
materials,
an
emphasis
novel
cascade
synthetic
methodologies
via
C−N/C−C
well
mechanisms
reactions,
especially
oxidation
steps.
We
hope
this
will
help
researchers
looking
prepare
minimum
steps
those
who
want
develop
new
based
activation/functionalizations.
European Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
Abstract
Nitrogen‐containing
heterocyclic
compounds
are
the
core
skeletons
of
many
natural
products,
bioactive
molecules
and
drugs,
transition
metal‐catalyzed
hydrazine‐directed
C−H
bond
activation/annulation
reactions
is
one
effective
methods
for
synthesis
nitrogen‐containing
compounds.
In
this
review,
important
research
progress
activation
reviewed
according
to
size
constructed
heterocycles,
substrate
scope
reaction
mechanism
discussed
in
detail,
limitations
future
development
prospects
summarized
outlooked.
