Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(24), P. 4320 - 4333
Published: Nov. 17, 2023
Benzofuran-
and
benzopyran-fused
polycyclic
acetals
are
found
in
a
variety
of
biologically
active
natural
products.
The
synthetic
methods
toward
this
class
heterocycles
have
fascinated
one
the
most
intensive
pursuits
total
synthesis.
Nevertheless,
stereoselective
towards
rapid
construction
such
skeletons
still
remain
challenging
for
organic
chemists.
Significant
progress
has
been
made
research
area
recent
years,
however,
literature
on
enantioselective
approaches
to
construct
these
molecules
not
fully
reviewed.
Driven
by
their
intriguing
complex
scaffolds
with
potential
usefulness,
we
compose
advances
review
covering
all
important
works
field.
We
hope
will
promote
future
area.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(15), P. 4104 - 4109
Published: Jan. 1, 2022
The
synthesis
of
dihydropyrazoles
enabled
by
Pd-catalyzed
carboamination
alkenyl
hydrazones
with
or
aryl
halides
is
described.
This
method
provides
a
practical
and
efficient
route
towards
the
functionalized
dihydropyrazoles.
Chemical Communications,
Journal Year:
2020,
Volume and Issue:
56(86), P. 13125 - 13128
Published: Jan. 1, 2020
A
highly
enantioselective
Pd/Xiang-Phos-catalyzed
carbohetero-functionalization
of
norbornene
is
described,
giving
a
direct
access
to
various
chiral
norbornane-fused
dihydrofurans
and
dihydro-pyrroles.
This
synthetic
methodology
provides
the
first
example
asymmetric
carboetherification
norbornene,
also
tolerates
norbornadiene
well.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
Here,
we
report
a
novel
strategy
for
the
preparation
of
diverse
heterocycles
via
Pd-catalyzed
migratory
1,1-cycloannulation
reaction
(MCAR)
alkenes.
Starting
from
readily
available
alkenyl
amines
and
alcohols,
this
approach
allows
formation
wide
range
five-
to
seven-membered
azaheterocycles
oxaheterocycles
with
high
efficiency
good
functional
group
tolerance.
The
key
realization
is
use
4-iodophenol
or
2-iodophenol
derivatives
where
phenolic
hydroxyl
plays
critical
role
in
controlling
direction
migration
ring-size
through
quinone
methide
intermediate.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(34)
Published: June 12, 2023
We
describe
a
catalytic
cascade
sequence
involving
directed
C(sp3
)-H
activation
followed
by
β-heteroatom
elimination
to
generate
PdII
(π-alkene)
intermediate
that
then
undergoes
redox-neutral
annulation
with
an
ambiphilic
aryl
halide
access
5-
and
6-membered
(hetero)cycles.
Various
alkyl
)-oxygen,
nitrogen,
sulfur
bonds
can
be
selectively
activated,
the
proceeds
high
diastereoselectivity.
The
method
enables
modification
of
amino
acids
good
retention
enantiomeric
excess,
as
well
σ-bond
ring-opening/ring-closing
transfiguration
low-strain
heterocycles.
Despite
its
mechanistic
complexity,
employs
simple
conditions
is
operationally
straightforward
perform.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(24), P. 4320 - 4333
Published: Nov. 17, 2023
Benzofuran-
and
benzopyran-fused
polycyclic
acetals
are
found
in
a
variety
of
biologically
active
natural
products.
The
synthetic
methods
toward
this
class
heterocycles
have
fascinated
one
the
most
intensive
pursuits
total
synthesis.
Nevertheless,
stereoselective
towards
rapid
construction
such
skeletons
still
remain
challenging
for
organic
chemists.
Significant
progress
has
been
made
research
area
recent
years,
however,
literature
on
enantioselective
approaches
to
construct
these
molecules
not
fully
reviewed.
Driven
by
their
intriguing
complex
scaffolds
with
potential
usefulness,
we
compose
advances
review
covering
all
important
works
field.
We
hope
will
promote
future
area.
