Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(5), P. 1292 - 1292
Published: April 27, 2023
Skin
cancer
is
one
of
the
most
common
types
cancer,
and
its
incidence
continues
to
increase.
It
divided
into
two
main
categories,
melanoma
non-melanoma.
Treatments
include
surgery,
radiation
therapy,
chemotherapy.
The
relatively
high
mortality
in
existing
recurrence
rates,
both
for
non-melanoma,
create
need
studying
developing
new
approaches
skin
management.
Recent
studies
have
focused
on
immunotherapy,
photodynamic
photothermal
photoimmunotherapy.
Photoimmunotherapy
has
gained
much
attention
due
excellent
potential
outcomes.
combines
advantages
and/or
therapy
with
a
systemic
immune
response,
making
it
ideal
metastatic
cancer.
This
review
critically
discusses
different
nanomaterials’
properties
mechanisms
action
photoimmunotherapy
results
obtained
field.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
35, P. 181 - 207
Published: Feb. 2, 2024
Peptide
molecules
have
design
flexibility,
self-assembly
ability,
high
biocompatibility,
good
biodegradability,
and
easy
functionalization,
which
promote
their
applications
as
versatile
biomaterials
for
tissue
engineering
biomedicine.
In
addition,
the
functionalization
of
self-assembled
peptide
nanomaterials
with
other
additive
components
enhances
stimuli-responsive
functions,
promoting
function-specific
that
induced
by
both
internal
external
stimulations.
this
review,
we
demonstrate
recent
advance
in
molecular
design,
self-assembly,
functional
tailoring,
biomedical
peptide-based
nanomaterials.
The
strategies
on
synthesis
single,
dual,
multiple
various
dimensions
are
analyzed,
regulation
active
such
metal/metal
oxide,
DNA/RNA,
polysaccharides,
photosensitizers,
2D
materials,
others
discussed.
designed
temperature-,
pH-,
ion-,
light-,
enzyme-,
ROS-responsive
abilities
drug
delivery,
bioimaging,
cancer
therapy,
gene
antibacterial,
well
wound
healing
dressing
presented
This
comprehensive
review
provides
detailed
methodologies
advanced
techniques
from
biology,
materials
science,
nanotechnology,
will
guide
inspire
level
peptides
specific
functions
applications.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(18)
Published: Feb. 28, 2022
Downregulating
programmed
cell
death
ligand
1(PD-L1)
protein
levels
in
tumor
cells
is
an
effective
way
to
achieve
immune
system
activation
for
oncology
treatment,
but
current
strategies
are
inadequate.
Here,
we
design
a
caged
peptide-AIEgen
probe
(GCP)
self-assemble
with
miR-140
forming
GCP/miR-140
nanoparticles.
After
entering
cells,
disassembles
the
presence
of
Cathepsin
B
(CB)
and
releases
GO203
peptide,
PyTPA.
Peptide
decages
highly
reductive
intracellular
environment
binds
mucin
1
(MUC1),
thereby
downregulating
expression
PD-L1.
Meanwhile,
reduces
PD-L1
by
targeting
downregulation
mRNA.
Under
action
PyTPA-mediated
photodynamic
therapy
(PDT),
tumor-associated
antigens
released,
triggering
attack
on
cells.
This
multiple
mechanism-based
strategy
deeply
activates
thus
achieves
immunotherapy.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2655 - 2655
Published: Jan. 31, 2023
Near
infrared
photoimmunotherapy
(NIR-PIT)
is
a
newly
developed
molecular
targeted
cancer
treatment,
which
selectively
kills
cells
or
immune-regulatory
and
induces
therapeutic
host
immune
responses
by
administrating
targeting
moiety
conjugated
with
IRdye700.
The
local
exposure
to
near-infrared
(NIR)
light
causes
photo-induced
ligand
release
reaction,
damage
the
target
cell,
resulting
in
immunogenic
cell
death
(ICD)
little
no
side
effect
surrounding
normal
cells.
Moreover,
NIR-PIT
can
generate
an
response
distant
metastases
inhibit
further
attack
combing
regulatory
other
treatment
modalities.
Several
recent
improvements
have
been
explored
such
as
catheter-driven
NIR
delivery,
real-time
monitoring
of
cancer,
development
new
molecule,
leading
being
considered
promising
therapy.
In
this
review,
we
discuss
progress
NIR-PIT,
their
mechanism
design
strategies
for
treatment.
Furthermore,
overall
possible
molecules
application
are
briefly
summarised.
Small Methods,
Journal Year:
2023,
Volume and Issue:
7(5)
Published: Jan. 31, 2023
Abstract
Immunogenic
cell
death
(ICD)‐induced
immunotherapy
holds
promise
for
complete
elimination
and
long‐term
protective
immune
responses
against
cancer
by
combining
direct
tumor
killing
antitumor
response.
Some
therapeutic
approaches
(such
as
hyperthermia,
photodynamic
therapy,
or
radiotherapy)
inducers
(certain
chemotherapy
drugs,
oncolytic
viruses)
have
been
devoted
to
initiating
and/or
boosting
ICD,
leading
the
activation
of
tumor‐specific
responses.
Recently,
supramolecular
assembled
bioactive
peptide
nanodrugs
employed
improve
efficacy
ICD‐induced
increasing
targeted
accumulation
well
responsive
release
ICD
inducers,
directly
inducing
high
levels
realizing
simultaneous
enhancement
response
through
function
active
itself.
Here,
authors
review
based
on
assembly,
mainly
an
intelligent
delivery
system,
a
inducer
enhancer,
induced
immunotherapy.
The
functions
diverse
peptides
used
in
construction
are
described.
design
mechanism
synergetic
effects
combined
critically
emphasized.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(8)
Published: Nov. 9, 2023
Abstract
Near‐infrared
(NIR)
light
is
well‐suited
for
the
optical
imaging
and
wireless
phototherapy
of
malignant
diseases
because
its
deep
tissue
penetration,
low
autofluorescence,
weak
scattering,
non‐invasiveness.
Rare
earth
nanoparticles
(RENPs)
are
promising
NIR‐responsive
materials,
owing
to
their
excellent
physical
chemical
properties.
The
4f
electron
subshell
lanthanides,
main
group
rare
elements,
has
rich
energy‐level
structures.
This
facilitates
broad‐spectrum
light‐to‐light
conversion
other
forms
energy,
such
as
thermal
energies.
In
addition,
abundant
loadable
modifiable
sites
on
surface
offer
favorable
conditions
functional
expansion
RENPs.
this
review,
authors
systematically
discuss
processes
mechanisms
underlying
response
RENPs
NIR
summarize
recent
advances
in
applications
imaging,
photothermal
therapy,
photodynamic
photoimmunotherapy,
optogenetics,
light‐responsive
drug
release.
Finally,
challenges
opportunities
application
under
activation
considered.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(3), P. 950 - 957
Published: Jan. 10, 2024
Sonodynamic
therapy
(SDT)
was
hampered
by
the
sonosensitizers
with
low
bioavailability,
tumor
accumulation,
and
therapeutic
efficiency.
In
situ
responsive
sonosensitizer
self-assembly
strategy
may
provide
a
promising
route
for
cancer
sonotheranositics.
Herein,
an
intelligent
sonotheranostic
peptide–purpurin
conjugate
(P18-P)
is
developed
that
can
self-assemble
into
supramolecular
structures
via
self-aggregation
triggered
rich
enzyme
cathepsin
B
(CTSB).
After
intravenous
injection,
versatile
probe
could
achieve
deep
tissue
penetration
because
of
sequence
P18-P.
More
importantly,
CTSB-triggered
strongly
prolonged
retention
time,
amplified
photoacoustic
imaging
signal
sensitive
CTSB
detection,
boosted
reactive
oxygen
species
advanced
SDT,
evoking
specific
sonotheranostics.
This
serve
as
efficient
platform
early
diagnosis
activity
effective
therapy.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 26, 2025
The
integration
of
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
offers
a
promising
strategy
for
enhancing
phototherapy
efficiency.
Herein,
we
present
dual-functional,
biocompatible
nanocomposite
system
combination
PDT/PTT
therapy.
utilizes
highly
nanoparticle
assembled
by
an
amphiphilic
short
peptide
with
the
assistance
Zn2+
as
carrier.
convertor
is
loaded
within
nanoparticle,
while
cationic
porphyrin
photosensitizer
on
surface.
water-soluble
(M8PzEOPP),
designed
eight
positive
charges,
provides
strong
electrostatic
interaction
stable
assembly
This
location-independent
effectively
maintains
optical
characteristics
both
convertor,
endowing
effective
properties.
exhibits
excellent
tumor-targeting
accumulation
behavior,
low
dark
toxicity,
robust
extracellular
biostability,
high
cell
internalization
Its
enhanced
performance
in
combinatorial
demonstrated
through
vitro
vivo
experiments.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 2043 - 2057
Published: Feb. 1, 2025
Natural
enzyme
systems
possess
extraordinary
functions
and
characteristics,
making
them
highly
appealing
for
use
in
eco-friendly
technologies
innovative
cancer
treatments.
However,
their
inherent
instability
structural
complexity
often
limit
practical
applications,
leading
to
the
exploration
of
biomolecular
nanozyme
alternatives.
Supramolecular
nanozymes,
constructed
using
self-assembly
techniques
various
non-covalent
interactions,
have
emerged
as
a
promising
solution.
Amino
acids,
peptides,
protein
motifs
offer
flexible
building
blocks
constructing
these
nanozymes.
Importantly,
well-defined
regulation
mechanisms
along
with
unique
properties
fundamental
biological
modules
living
systems-such
selectivity,
permeability,
retention,
biocompatibility-present
new
opportunities
therapy.
This
review
highlights
recent
advances
supramolecular
self-assembled
including
peroxidases,
oxidases,
catalases,
superoxide
dismutases,
other
systems,
tumor
Additionally,
it
discusses
precise
functional
modulation
through
interactions
therapeutic
applications
targeting
microenvironment.
These
studies
provide
valuable
insights
that
may
inspire
design
novel
nanozymes
enhanced
catalytic
biocompatibility,
tumor-killing
efficacy.
