Small,
Journal Year:
2023,
Volume and Issue:
19(11)
Published: Jan. 1, 2023
Abstract
The
combination
of
photodynamic
therapy
(PDT)
and
chemotherapy
(chemo‐photodynamic
therapy)
for
enhancing
cancer
therapeutic
efficiency
has
attracted
tremendous
attention
in
the
recent
years.
However,
limitations,
such
as
low
local
concentration,
non‐suitable
treatment
light
source,
uncontrollable
release
agents,
result
reduced
combined
efficacy.
This
study
considered
adenosine
triphosphate
(ATP),
which
is
highly
upregulated
tumor
cells,
a
biomarker
developed
ingenious
ATP‐activated
nanoparticles
(CDNPs)
that
are
directly
self‐assembled
from
near‐infrared
photosensitizer
(Cy‐I)
amphiphilic
Cd(II)
complex
(DPA‐Cd).
After
selective
entry
into
positively
charged
CDNPs
would
escape
lysosomes
be
disintegrated
by
high
ATP
concentration
cytoplasm.
released
Cy‐I
capable
producing
single
oxygen
(
1
O
2
)
PDT
with
808
nm
irradiation
DPA‐Cd
can
concurrently
function
chemotherapy.
Irradiation
lead
to
ablation
tumor‐bearing
mice
after
intravenous
injection
CDNPs.
carrier‐free
nanoparticle
offers
new
platform
chemo‐photodynamic
therapy.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(8), P. 1891 - 1891
Published: April 14, 2023
Porous
organic
polymers
(POPs)
have
plenteous
exciting
features
due
to
their
attractive
combination
of
microporosity
with
π-conjugation.
Nevertheless,
electrodes
based
on
pristine
forms
suffer
from
severe
poverty
electrical
conductivity,
precluding
employment
within
electrochemical
appliances.
The
conductivity
POPs
may
be
significantly
improved
and
porosity
properties
could
further
customized
by
direct
carbonization.
In
this
study,
we
successfully
prepared
a
microporous
carbon
material
(Py-PDT
POP-600)
the
carbonization
Py-PDT
POP,
which
was
designed
using
condensation
reaction
between
6,6′-(1,4-phenylene)bis(1,3,5-triazine-2,4-diamine)
(PDA-4NH2)
4,4′,4′′,4′′′-(pyrene-1,3,6,8-tetrayl)tetrabenzaldehyde
(Py-Ph-4CHO)
in
presence
dimethyl
sulfoxide
(DMSO)
as
solvent.
obtained
POP-600
high
nitrogen
content
had
surface
area
(up
314
m2
g−1),
pore
volume,
good
thermal
stability
N2
adsorption/desorption
data
thermogravimetric
analysis
(TGA).
Owing
area,
as-prepared
showed
excellent
performance
CO2
uptake
(2.7
mmol
g−1
at
298
K)
specific
capacitance
550
F
0.5
A
compared
POP
(0.24
28
g−1).
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(19), P. 3323 - 3323
Published: Sept. 24, 2022
In
recent
years,
gene
therapy
has
made
remarkable
achievements
in
tumor
treatment.
a
successfully
cancer
therapy,
smart
delivery
system
is
necessary
for
both
protecting
the
therapeutic
genes
circulation
and
enabling
high
expression
sites.
Magnetic
iron
oxide
nanoparticles
(IONPs)
have
demonstrated
their
bright
promise
highly
efficient
target
to
tissues,
partly
due
good
biocompatibility,
magnetic
responsiveness,
extensive
functional
surface
modification.
this
review,
latest
progress
targeting
introduced,
unique
properties
of
IONPs
contributing
are
summarized
with
detailed
examples.
Furthermore,
diagnosis
potentials
synergistic
treatment
capacity
highlighted.
addition,
aiming
at
potential
risks
during
process,
several
strategies
improve
efficiency
or
reduce
using
introduced
addressed.
The
applications
review
provide
general
understanding
therapy.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(3)
Published: Nov. 16, 2023
Lung
cancer
is
the
second
most
prevalent
and
leading
cause
of
cancer-related
death
worldwide.
Surgery,
chemotherapy,
molecular
targeted
therapy,
immunotherapy,
radiotherapy
are
currently
available
as
treatment
methods.
However,
drug
resistance
a
significant
factor
in
failure
lung
treatments.
Novel
therapeutics
have
been
exploited
to
address
complicated
mechanisms
advancement
nanomedicine
extremely
promising
terms
overcoming
resistance.
Nanomedicine
equipped
with
multifunctional
tunable
physiochemical
properties
alignment
tumor
genetic
profiles
can
achieve
precise,
safe,
effective
while
minimizing
or
eradicating
cancer.
Here,
this
work
reviews
discovered
for
radiotherapy,
outlines
novel
strategies
development
against
This
focuses
on
engineering
design,
customized
delivery,
current
challenges,
clinical
translation
application
resistant
Small,
Journal Year:
2023,
Volume and Issue:
19(11)
Published: Jan. 1, 2023
Abstract
The
combination
of
photodynamic
therapy
(PDT)
and
chemotherapy
(chemo‐photodynamic
therapy)
for
enhancing
cancer
therapeutic
efficiency
has
attracted
tremendous
attention
in
the
recent
years.
However,
limitations,
such
as
low
local
concentration,
non‐suitable
treatment
light
source,
uncontrollable
release
agents,
result
reduced
combined
efficacy.
This
study
considered
adenosine
triphosphate
(ATP),
which
is
highly
upregulated
tumor
cells,
a
biomarker
developed
ingenious
ATP‐activated
nanoparticles
(CDNPs)
that
are
directly
self‐assembled
from
near‐infrared
photosensitizer
(Cy‐I)
amphiphilic
Cd(II)
complex
(DPA‐Cd).
After
selective
entry
into
positively
charged
CDNPs
would
escape
lysosomes
be
disintegrated
by
high
ATP
concentration
cytoplasm.
released
Cy‐I
capable
producing
single
oxygen
(
1
O
2
)
PDT
with
808
nm
irradiation
DPA‐Cd
can
concurrently
function
chemotherapy.
Irradiation
lead
to
ablation
tumor‐bearing
mice
after
intravenous
injection
CDNPs.
carrier‐free
nanoparticle
offers
new
platform
chemo‐photodynamic
therapy.
