Skin-Interfaced Wearable Sweat Sensors for Precision Medicine

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(8), P. 5049 - 5138

Published: March 27, 2023

Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward healthcare. Advances flexible electronics, materials science, electrochemistry have spurred the development of wearable sweat that enable continuous noninvasive screening analytes indicative status. Existing major challenges include: improving extraction sensing capabilities, form factor device for minimal discomfort reliable measurements when worn, understanding clinical value biomarker discovery. This review provides a comprehensive outlines state-of-the-art technologies research strive to bridge these gaps. The physiology sweat, materials, biosensing mechanisms advances, approaches induction sampling are introduced. Additionally, design considerations system-level devices, spanning from strategies prolonged efficient powering wearables, discussed. Furthermore, applications, data commercialization efforts, challenges, prospects precision medicine

Language: Английский

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High-performance piezoelectric composites via β phase programming

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 18, 2022

Polymer-ceramic piezoelectric composites, combining high piezoelectricity and mechanical flexibility, have attracted increasing interest in both academia industry. However, their activity is largely limited by intrinsically low crystallinity weak spontaneous polarization. Here, we propose a Ti3C2Tx MXene anchoring method to manipulate the intermolecular interactions within all-trans conformation of polymer matrix. Employing phase-field simulation molecular dynamics calculations, show that OH surface terminations on nanosheets offer hydrogen bonding with fluoropolymer matrix, leading dipole alignment enhanced net polarization polymer-ceramic composites. We then translated this interfacial strategy into electrospinning boost response samarium doped Pb (Mg1/3Nb2/3)O3-PbTiO3/polyvinylidene fluoride composite nanofibers 160% via inclusion. With excellent attributes, as-electrospun can be easily integrated conventional shoe insoles form foot sensor network for all-around gait patterns monitoring, walking habits identification Metatarsalgi prognosis. This work utilizes coupling mechanism as develop high-performance composites wearable electronics.

Language: Английский

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Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

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Advanced Fiber Materials for Wearable Electronics

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 5(1), P. 12 - 35

Published: Oct. 13, 2022

Abstract Fiber materials are highly desirable for wearable electronics that expected to be flexible and stretchable. Compared with rigid planar electronic devices, fiber-based provide significant advantages in terms of flexibility, stretchability breathability, they considered as the pioneers new generation soft wearables. The convergence textile science, engineering nanotechnology has made it feasible build functions on fibers maintain them during wear. Over last few years, fiber-shaped desired designability integration features have been intensively explored developed. As an indispensable part cornerstone great significance. Herein, research progress advanced fiber is reviewed, which mainly includes various material preparations, fabrication technologies representative studies different applications. Finally, key challenges future directions examined along analysis possible solutions. Graphical abstract

Language: Английский

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Piezocatalytic Techniques in Environmental Remediation

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(5)

Published: Nov. 1, 2022

Abstract As a consequence of rapid industrialization throughout the world, various environmental pollutants have begun to accumulate in water, air, and soil. This endangers ecological environment earth, remediation has become an immediate priority. Among techniques, piezocatalytic which uniquely take advantage piezoelectric effect, attracted much attention. Piezoelectric effects allow pollutant degradation directly, while also enhancing photocatalysis by reducing recombination photogenerated carriers. In this Review, we provide comprehensive summary recent developments techniques for remediation. The origin effect as well classification materials their application are systematically summarized. We analyze potential underlying mechanisms. Finally, urgent problems future development discussed.

Language: Английский

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Materials-Driven Soft Wearable Bioelectronics for Connected Healthcare

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(2), P. 455 - 553

Published: Jan. 4, 2024

In the era of Internet-of-things, many things can stay connected; however, biological systems, including those necessary for human health, remain unable to connected global Internet due lack soft conformal biosensors. The fundamental challenge lies in fact that electronics and biology are distinct incompatible, as they based on different materials via functioning principles. particular, body is curvilinear, yet typically rigid planar. Recent advances design have generated tremendous opportunities wearable bioelectronics, which may bridge gap, enabling ultimate dream healthcare anyone, anytime, anywhere. We begin with a review historical development healthcare, indicating significant trend healthcare. This followed by focal point discussion about new design, particularly low-dimensional nanomaterials. summarize material types their attributes designing bioelectronic sensors; we also cover synthesis fabrication methods, top-down, bottom-up, combined approaches. Next, discuss energy challenges progress made date. addition front-end devices, describe back-end machine learning algorithms, artificial intelligence, telecommunication, software. Afterward, integration systems been applied various testbeds real-world settings, laboratories preclinical clinical environments. Finally, narrate remaining conjunction our perspectives.

Language: Английский

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Advances in Wearable Strain Sensors Based on Electrospun Fibers

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(18)

Published: Feb. 25, 2023

Abstract Wearable strain sensors with the ability of detecting physiological activities play an important role in personalized healthcare. Electrospun fibers have become a popular building block for wearable due to their excellent mechanical properties, breathability, and light weight. In this review, structure preparation process electrospun conductive layer are systematically introduced. The impact materials structures on following discussion sensing performance optimization strategies is outlined. Furthermore, applications fiber‐based biomonitoring, motion detection, human‐machine interaction presented. Finally, challenges promising future directions community based pointed out.

Language: Английский

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Smart Textiles for Healthcare and Sustainability

ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 13301 - 13313

Published: Aug. 15, 2022

At the forefront of smart textile community, healthcare and sustainability are two crucial objectives targeted by researchers. The development such powerful devices has been driven innovative fabrications breathable, skin-conformable technologies through use functional programmable materials device structures. This Perspective focuses on current textiles available in research field, categorized into personalized healthcare, including diagnostics therapeutics, sustainability, energy harvesting conservation─personalized thermoregulation. These categories further broken down their platform structural performances. Furthermore, we give a comprehensive overview highlight few examples studies. Finally, provide an outlook these for future researchers to participate. We envision that next generation will revolutionize wearable technology sustainability.

Language: Английский

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Bioinspired MXene‐Based Piezoresistive Sensor with Two‐stage Enhancement for Motion Capture

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(18)

Published: Feb. 9, 2023

Abstract Structured piezoresistive membranes are compelling building blocks for wearable bioelectronics. However, the poor structural compressibility of conventional microstructures leads to rapid saturation detection range and low sensitivity devices, limiting their commercial applications. Herein, a bioinspired MXene‐based device is reported, which can effectively boost while broadening response by architecting intermittent villus‐like microstructures. Benefitting from two‐stage amplification effect this architecture, developed bioelectronics exhibit high 461 kPa −1 broad pressure up 311 kPa, about 20 5 times higher than that homogeneous microstructures, respectively. Cooperating with deep‐learning algorithm, designed capture complex human movements precisely identify motion recognition accuracy 99%. Evidently, architecture biomimetic strategy may pave promising avenue overcome limitation in bioelectronics, provide general way promote its large‐scale

Language: Английский

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Oxygen‐Vacancy‐Rich Piezoelectric BiO_2−x Nanosheets for Augmented Piezocatalytic, Sonothermal, and Enzymatic Therapies

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(29)

Published: April 14, 2023

Abstract Piezocatalytic therapy is a new‐emerging reactive oxygen species (ROS)‐enabled therapeutic strategy that relies on built‐in electric field and energy‐band bending of piezoelectric materials activated by ultrasound (US) irradiation. Despite becoming hot topic, material development mechanism exploration are still underway. Herein, as‐synthesized oxygen‐vacancy‐rich BiO 2− x nanosheets (NSs) demonstrate outstanding properties. Under US, piezo‐potential 0.25 V for NSs sufficient to tilt the conduction band be more negative than redox potentials O 2 / • − , /H H OH, which initiates cascade reaction ROS generation. Moreover, exhibit peroxidase oxidase‐like activities augment production, especially in ‐overexpressed tumor microenvironment. Density functional theory calculations show generated vacancies favorable adsorption increasing carrier density produce ROS. Furthermore, quick movement electrons enables an excellent sonothermal effect, example, rapid rise temperature nearly 65 °C upon US with low power (1.2 W cm −2 ) short time (96 s). Therefore, this system realizes multimode synergistic combination piezocatalytic, enzymatic, therapies, providing new direction defect engineering‐optimized therapy.

Language: Английский

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