Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 8, 2024
Aryl
thianthrenium
salts
are
valuable
in
photocatalysis
but
traditionally
require
external
electron
donors
for
activation.
This
study
introduces
an
energy
transfer
(EnT)
strategy
the
activation
of
aryl
using
2,3,4,5,6-penta(carbazol-9-yl)benzonitrile
(5CzBN)
as
a
metal-free
photocatalyst,
eliminating
need
donors.
Utilizing
this
EnT
approach,
we
achieve
C-H
deuteration
arenes
under
visible
light
with
CDCl
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(15), P. 4318 - 4342
Published: Jan. 1, 2024
This
review
primarily
focuses
on
the
generation
of
aryl
radicals
via
an
electroreduction
strategy,
and
systematically
elaborates
synthetic
applications,
scope,
limitations
substrates.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(3), P. 569 - 569
Published: Jan. 23, 2024
Radical
reactions
in
water
or
aqueous
media
are
important
for
organic
synthesis,
realizing
high-yielding
processes
under
non-toxic
and
environmentally
friendly
conditions.
This
overview
includes
(i)
a
general
introduction
to
chemistry
media,
(ii)
synthetic
approaches
in,
on,
with
as
well
heterogeneous
phases,
(iii)
of
carbon-centered
radicals
(or
deuterium
oxide)
activated
through
coordination
various
Lewis
acids,
(iv)
photocatalysis
(v)
applications
bioinspired
by
naturally
occurring
processes.
A
wide
range
chemical
strategies
different
experimental
conditions
have
been
reviewed
that
lead
functional
group
translocation
transformation
reactions,
leading
the
preparation
complex
molecules.
These
results
reveal
how
solvent/medium/reagent
radical
has
matured
over
last
two
decades,
further
discoveries
anticipated
near
future.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(28)
Published: April 30, 2024
Abstract
The
development
of
green
and
efficient
deuteration
methods
is
great
significance
for
various
fields
such
as
organic
synthesis,
analytical
chemistry,
medicinal
chemistry.
Herein,
we
have
developed
a
dehalogenative
strategy
using
piezoelectric
materials
catalysts
in
solid‐phase
system
under
ball‐milling
conditions.
This
non‐spontaneous
reaction
induced
by
mechanical
force.
D
2
O
can
serve
both
deuterium
source
an
electron
donor
the
transformation,
eliminating
need
additional
stoichiometric
exogenous
reductants.
A
series
(hetero)aryl
iodides
be
transformed
into
deuterated
products
with
high
incorporation.
method
not
only
effectively
overcomes
existing
synthetic
challenges
but
also
used
labelling
drug
molecules
derivatives.
Bioactivity
experiments
molecule
suggest
that
D‐ipriflavone
enhances
inhibitory
effects
on
osteoclast
differentiation
BMDMs
vitro
.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(29), P. 11418 - 11427
Published: Jan. 1, 2024
An
environmentally
friendly
electroreduction
approach
is
disclosed
for
site-specific
introduction
of
deuterium
via
anti-Markovnikov
selective
deuteroarylation
alkenes
and
aryl
iodides
with
bipyridine
as
a
mediator
D
2
O
‘D’
source.
The
use
of
magnesium
and
methanol
in
the
reduction
various
functional
groups
has
been
well
established.
In
this
study,
we
present
a
reductive
deuteration
system
using
Mg/CH
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 20, 2025
The
development
of
practical
and
selective
strategies
for
deuterium
incorporation
to
construct
deuterated
molecules,
particularly
deuterium-labeled
amino
acids,
has
become
as
a
growing
focus
basic
research,
yet
it
remains
formidable
challenge.
Herein,
we
present
bioinspired
calcium-HFIP-mediated
site-selective
reductive
deutero-amination
α-oxo-carbonyl
compounds
with
amines.
Utilizing
d2-Hantzsch
ester
the
source,
this
reaction
attains
remarkable
deuteration
efficiency
(>
99%
deuteration).
It
enables
synthesis
N-α-deuterated
acid
motifs
wide
range
functionality,
evidenced
by
over
130
examples.
method
exhibits
compatibility
diverse
substrates,
such
peptides,
drug
natural
products
bearing
different
substituents.
Moreover,
application
strategy
in
DNA-tagged
acids/peptides
been
demonstrated.
This
work
offers
an
efficient
innovative
solution
chemistry
holds
substantial
potential
organic
synthesis,
medicinal
chemistry,
chemical
biology.
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(5)
Published: April 8, 2023
Abstract
Ring‐fused
polycyclic
structures
widely
exist
in
a
myriad
of
natural
products
and
pharmaceutical
molecules.
Consequently,
the
construction
such
from
readily
available
substrates
becomes
an
important
researching
topic
organic
synthesis.
Triggered
by
addition
radicals
to
(activated
or
unactivated)
double
bonds
alkenes,
subsequent
intramolecular
addition/cyclization
leads
compounds.
Following
this
procedure,
variety
functionalized
ring‐fused
were
formed.
Great
achievements
have
been
witnessed
recently.
Those
works
provided
efficient,
atom
economy,
operational
simple
approaches
toward
versatile
alkene‐based
substrates.
Here,
we
summarized
recent
on
formation
via
radical‐triggered
cascade
reactions
alkenes.
Construction
with
no
less
than
3
fused
rings
developed
during
last
decade
included
Review,
corresponding
mechanisms
also
discussed.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(2), P. 328 - 343
Published: Jan. 29, 2024
Hydrogenation
is
a
crucial
chemical
process
employed
in
myriad
of
industries,
often
facilitated
by
metals
such
as
Pd,
Pt,
and
Ni
catalysts.
Traditional
thermocatalytic
hydrogenation
usually
necessitates
high
temperature
elevated
pressure,
making
the
energy
intensive.
Electrocatalytic
offers
an
alternative
but
suffers
from
issues
competing
H
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(36)
Published: June 13, 2024
Isotopically
labeled
alkanes
play
a
crucial
role
in
organic
and
pharmaceutical
chemistry.
While
some
deuterated
methylating
agents
are
readily
available,
the
limited
accessibility
of
other
deuteroalkyl
reagents
has
hindered
synthesis
corresponding
products.
In
this
study,
we
introduce
nickel-catalyzed
system
that
facilitates
various
deuterium-labeled
through
hydrodeuteroalkylation
d2-labeled
alkyl
TT
salts
with
unactivated
alkenes.
Diverging
from
traditional
reagents,
thianthrenium
(TT)
can
effectively
selectively
deuterium
at
α
position
chains
using
D
