International Journal of Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 8
Published: Sept. 27, 2022
A
new
method
was
developed
for
the
identification
and
determination
of
L-ergothioneine
in
cosmetics
based
on
ultraperformance
liquid
chromatography-tandem
mass
spectrometry
(UPLC-MS/MS).
The
pretreatment
method,
chromatographic
column,
conditions,
spectrometric
conditions
cosmetic
samples
were
optimized.
Methanol
chosen
as
extraction
solvent,
85%
acetonitrile
with
0.1%
FA
selected
mobile
phase,
Waters
CORTECS
UPLC
hydrophilic
interaction
chromatography
(HILIC)
column
separation.
sample
extracted
methanol
filtered,
then
separated
by
HILIC
detected
triple-quadrupole
spectrometry.
quantitation
done
under
matrix
calibration
curve
using
external
standard
method.
results
showed
good
linear
relationships
range
5–200
ng/mL,
correlation
coefficient
greater
than
0.999
samples.
limit
detection
25–50
μg/kg
50–100
μg/kg.
recoveries
spiked
ranged
from
85.3%
to
96.2%
relative
deviation
(RSD)
0.84%–2.08%
(n
=
6).
is
simple,
quick,
accurate
cosmetics,
has
great
practical
value.
Archives of Toxicology,
Journal Year:
2023,
Volume and Issue:
97(10), P. 2499 - 2574
Published: Aug. 19, 2023
Abstract
A
physiological
level
of
oxygen/nitrogen
free
radicals
and
non-radical
reactive
species
(collectively
known
as
ROS/RNS)
is
termed
oxidative
eustress
or
“good
stress”
characterized
by
low
to
mild
levels
oxidants
involved
in
the
regulation
various
biochemical
transformations
such
carboxylation,
hydroxylation,
peroxidation,
modulation
signal
transduction
pathways
Nuclear
factor-κB
(NF-κB),
Mitogen-activated
protein
kinase
(MAPK)
cascade,
phosphoinositide-3-kinase,
nuclear
factor
erythroid
2–related
2
(Nrf2)
other
processes.
Increased
ROS/RNS,
generated
from
both
endogenous
(mitochondria,
NADPH
oxidases)
and/or
exogenous
sources
(radiation,
certain
drugs,
foods,
cigarette
smoking,
pollution)
result
a
harmful
condition
stress
(“bad
stress”).
Although
it
widely
accepted,
that
many
chronic
diseases
are
multifactorial
origin,
they
share
common
denominator.
Here
we
review
importance
mechanisms
through
which
contributes
pathological
states
an
organism.
Attention
focused
on
chemistry
ROS
RNS
(e.g.
superoxide
radical,
hydrogen
peroxide,
hydroxyl
radicals,
peroxyl
nitric
oxide,
peroxynitrite),
their
role
damage
DNA,
proteins,
membrane
lipids.
Quantitative
qualitative
assessment
biomarkers
also
discussed.
Oxidative
pathology
cancer,
cardiovascular
diseases,
diabetes,
neurological
disorders
(Alzheimer’s
Parkinson’s
Down
syndrome),
psychiatric
(depression,
schizophrenia,
bipolar
disorder),
renal
disease,
lung
disease
(chronic
pulmonary
obstruction,
cancer),
aging.
The
concerted
action
antioxidants
ameliorate
effect
achieved
antioxidant
enzymes
(Superoxide
dismutases-SODs,
catalase,
glutathione
peroxidase-GPx),
small
molecular
weight
(vitamins
C
E,
flavonoids,
carotenoids,
melatonin,
ergothioneine,
others).
Perhaps
one
most
effective
vitamin
first
line
defense
against
peroxidation
promising
approach
appears
be
use
flavonoids),
showing
weak
prooxidant
properties
may
boost
cellular
systems
thus
act
preventive
anticancer
agents.
Redox
metal-based
enzyme
mimetic
compounds
potential
pharmaceutical
interventions
sirtuins
therapeutic
targets
for
age-related
anti-aging
strategies
Annual Review of Food Science and Technology,
Journal Year:
2023,
Volume and Issue:
14(1), P. 323 - 345
Published: Jan. 10, 2023
This
article
reviews
what
is
presently
known
about
the
biological
roles
of
diet-derived
compound
ergothioneine
(ET).
ET
seems
important
to
humans
because
it
rapidly
taken
up
from
diet
by
a
transporter
largely
or
completely
specific
for
ET,
and
once
retained
within
body
weeks
months.
The
various
possible
functions
in
vivo
are
explored.
Much
emphasis
has
been
placed
on
antioxidant
properties
but
although
these
well
established
vitro,
evidence
that
activity
principal
function
weak.
not
unique
this:
vitamin
C
polyphenols
such
as
flavonoids
also
By
contrast,
α-tocopherol
demonstrated
effects
humans.
Experimental Gerontology,
Journal Year:
2022,
Volume and Issue:
170, P. 111982 - 111982
Published: Oct. 14, 2022
Healthy
ageing
is
a
crucial
process
that
needs
to
be
highlighted
as
it
affects
the
quality
of
lifespan.
An
increase
in
oxidative
stress
along
with
major
factor
related
age-associated
diseases,
especially
neurodegenerative
disorders.
antioxidant-rich
diet
has
been
proven
play
significant
role
process.
Targeting
mechanisms
could
worthwhile
approach
improving
health
standards.
Ergothioneine
(EGT),
hydrophilic
compound
specific
transporter
known
OCTN1,
shown
exert
anti-ageing
properties.
In
addition
its
antioxidant
effect,
EGT
reported
have
anti-senescence,
anti-inflammatory
and
anti-neurodegenerative
This
review
aims
define
pivotal
signalling
pathways
such
insulin/insulin-like
growth
(IGF)
(IIS),
sirtuin
6
(SIRT6)
mammalian
target
rapamycin
complex
(mTOR)
pathways.
The
further
discusses
evidence
on
neurodegeneration
therapeutic
context
various
model
organisms,
providing
new
insights
into
health.
conclusion,
an
ergothioneine-rich
may
beneficial
preventing
age-related
resulting
healthy
population.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(4), P. 1648 - 1648
Published: Feb. 8, 2023
Ergothioneine,
a
sulfur-containing
micromolecular
histidine
derivative,
has
attracted
increasing
attention
from
scholars
since
it
was
confirmed
in
the
human
body.
In
body,
ergothioneine
is
transported
and
accumulated
specifically
through
OCTN-1,
especially
mitochondria
nucleus,
suggesting
that
can
target
damaged
cells
tissues
as
an
antioxidant.
It
shows
excellent
antioxidant,
anti-inflammatory
effects,
anti-aging
properties,
inhibits
melanin
production.
mega
antioxidant
may
participate
network
system
promote
reducing
glutathione
regeneration
cycle.
This
review
summarizes
studies
on
effects
of
various
free
radicals
vitro
to
date
systematically
introduces
its
biological
activities
potential
mechanisms,
mostly
dermatology.
Additionally,
application
cosmetics
briefly
summarized.
Lastly,
we
propose
some
problems
require
solutions
understand
mechanism
action
ergothioneine.
We
believe
good
prospects
food
industries,
thus
meet
needs
health
beauty
industry.
GeroScience,
Journal Year:
2024,
Volume and Issue:
46(4), P. 3889 - 3909
Published: March 6, 2024
Abstract
Healthy
aging
has
emerged
as
a
crucial
issue
with
the
increase
in
geriatric
population
worldwide.
Food-derived
sulfur-containing
amino
acid
ergothioneine
(ERGO)
is
potential
dietary
supplement,
which
exhibits
various
beneficial
effects
experimental
animals
although
preventive
of
ERGO
on
and/or
age-related
impairments
such
frailty
and
cognitive
impairment
are
unclear.
We
investigated
daily
oral
supplementation
dissolved
drinking
water
lifespan,
frailty,
male
mice
from
7
weeks
age
to
end
their
lives.
Ingestion
4
~
5
mg/kg/day
remarkably
extended
lifespan
mice.
The
longevity
effect
was
further
supported
by
life
non-frailty
spans
Caenorhabditis
elegans
presence
ERGO.
Compared
control
group,
group
showed
significantly
lower
declines
weight,
fat
mass,
average
maximum
movement
velocities
at
88
age.
This
compatible
dramatical
suppression
increments
plasma
biomarkers
(BMs)
chemokine
ligand
9,
creatinine,
symmetric
dimethylarginine,
urea,
asymmetric
quinolinic
acid,
kynurenine.
intake
also
rescued
learning
memory
ability,
might
be
associated
decline
hippocampal
neurogenesis
TDP43
protein
aggregation
promotion
microglial
shift
M2
phenotype
ingestion.
may
promote
healthy
mice,
possibly
through
multiple
biological
mechanisms.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(20), P. 4368 - 4368
Published: Oct. 18, 2022
Nutrition
has
relevant
consequences
for
human
health
and
increasing
pieces
of
evidence
indicate
that
medicinal
mushrooms
have
several
beneficial
effects.
One
the
main
issues
in
Western
countries
is
represented
by
challenges
aging
age-related
diseases,
such
as
neurodegenerative
disorders.
Among
these,
Parkinson's
disease
(PD)
affects
10
million
people
worldwide
associated
with
α-synuclein
misfolding,
also
found
other
pathologies
collectively
called
synucleinopathies.
Here,
we
show
aqueous
extracts
two
edible
mushrooms,
Grifola
frondosa
Hericium
erinaceus,
represent
a
valuable
source
β-glucans
exert
anti-aging
effects
yeast.
Their
are
mediated
through
inhibition
Ras/PKA
pathway,
increased
expression
heat
shock
proteins,
along
consistent
increase
both
mean
maximal
lifespans.
These
fungal
reduce
toxicity
heterologously
expressed
yeast
cells,
resulting
reduced
ROS
levels,
lower
membrane
localization,
protein
aggregation.
The
neuroprotective
activity
G.
extract
was
confirmed
PD
model
Drosophila
melanogaster.
Taken
together,
our
data
suggest
use
H.
erinaceus
functional
food
to
prevent
disorders,
further
supporting
neuro-healthy
properties
these
mushroom
extracts.
Protein & Cell,
Journal Year:
2023,
Volume and Issue:
15(3), P. 191 - 206
Published: Aug. 10, 2023
Abstract
Ergothioneine,
Ovothiol,
and
Selenoneine
are
sulfur/selenium-containing
histidine-derived
natural
products
widely
distributed
across
different
organisms.
They
exhibit
significant
antioxidant
properties,
making
them
as
potential
lead
compounds
for
promoting
health.
Increasing
evidence
suggests
that
Ergothioneine
is
positively
correlated
with
healthy
ageing
longevity.
The
mechanisms
underlying
Ergothioneine's
regulation
of
the
process
at
cellular
molecular
levels
beginning
to
be
understood.
In
this
review,
we
provide
an
in-depth
extensive
coverage
anti-ageing
studies
on
discuss
its
possible
intracellular
targeting
pathways.
addition,
highlight
recent
efforts
in
elucidating
biosynthetic
details
Selenoneine,
a
particular
focus
study
their
pharmacophore-forming
enzymology.
