Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(7), P. 1595 - 1605
Published: Feb. 3, 2024
Abstract
Herein,
we
present
a
photoinduced
deconstructive
alkoxyamination
of
alkyl
alcohols
catalyzed
by
iron
salts.
This
transformation
involves
the
initiation
alkoxy
radicals
through
chlorine
radical‐induced
radical
formation,
followed
β
‐scission
and
trapping
resulting
carbon
with
2,2,6,6‐tetramethylpiperidin‐1‐yl
(TEMPO).
reaction
exhibits
broad
substrate
scope
(40
examples),
including
primary
secondary
that
are
prone
to
oxidation
combination
TEMPO
iron.
Mechanistic
investigations
have
revealed
enhanced
coordination
chloride
ion
center
inhibits
OH
process,
thereby
enabling
tolerance
alcohols.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(17), P. 9876 - 9885
Published: April 18, 2023
Herein,
we
report
a
redox-neutral
and
atom-economical
protocol
to
synthesize
valuable
alkenyl
chlorides
from
unactivated
internal
alkynes
abundant
organochlorides
via
photoredox
nickel
catalysis.
This
enables
the
site-
stereoselective
addition
of
chlorine
photoelimination-initiated
sequential
hydrochlorination/remote
C-H
functionalization.
The
is
compatible
with
wide
range
medicinally
relevant
heteroaryl,
aryl,
acid,
alkyl
for
efficiently
producing
γ-functionalized
chlorides,
exhibiting
excellent
regioselectivities
stereoselectivities.
Late-stage
modifications
synthetic
manipulations
products
preliminary
mechanistic
studies
are
also
presented.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(28), P. 5279 - 5284
Published: July 11, 2023
The
synthesis
of
tertiary
phosphines(III)
has
been
a
long-standing
challenge
in
synthetic
chemistry
because
inevitable
issues
including
harsh
conditions,
sensitive
organometallic
reagents,
and
prefunctionalized
substrates
traditional
synthesis.
Herein,
we
report
strategically
novel
C(sp3)-H
bond
phosphorylation
that
enables
the
assembly
structurally
diverse
from
industrial
phosphine(III)
sources
under
mild
photocatalytic
conditions.
merger
ligand-to-metal
charge
transfer
(LMCT)
FeCl3
with
hydrogen
atom-transfer
(HAT)
process
is
key
for
generation
alkyl
radicals
hydrocarbons.
Strikingly,
this
catalytic
system
can
be
successfully
applied
polymerization
electron-deficient
alkenes.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(18), P. 5278 - 5305
Published: Jan. 1, 2024
This
review
summarizes
the
latest
methodological
advances
in
photocatalytic
C(sp
3
)–H
functionalization,
with
a
particular
emphasis
on
formation
of
C–P,
C–B,
C–S
bonds,
etc
.,
and
some
prominent
efforts
asymmetric
C–H
functionalization.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 20, 2024
Abstract
Reforming
sustainable
3d-metal-based
visible
light
catalytic
platforms
for
inert
bulk
chemical
activation
is
highly
desirable.
Herein,
we
demonstrate
the
use
of
a
Brønsted
acid
to
unlock
robust
and
practical
iron
ligand-to-metal
charge
transfer
(LMCT)
photocatalysis
multifarious
haloalkylcarboxylates
(C
n
X
m
COO
−
,
=
F
or
Cl)
produce
C
radicals.
This
process
enables
fluoro-polyhaloalkylation
non-activated
alkenes
by
combining
easily
available
Selectfluor
as
fluorine
source.
Valuable
alkyl
fluorides
including
potential
drug
molecules
can
be
obtained
through
this
protocol.
Mechanistic
studies
indicate
that
real
light-harvesting
species
may
derive
from
in
situ-assembly
Fe
3+
H
+
acetonitrile
solvent,
which
indeed
increases
efficiency
LMCT
between
center
via
hydrogen-bond
interactions.
We
anticipate
acid-unlocked
platform
would
an
intriguing
option
execute
compounds.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(6), P. 1729 - 1735
Published: Jan. 1, 2024
An
iron-catalyzed
fragmentation
alkynylation,
alkenylation
and
alkylation
enabled
by
photoinduced
ligand-to-metal
charge
transfer
(LMCT)processis
herein
reported.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(62), P. 9424 - 9444
Published: Jan. 1, 2023
This
article
reviews
the
methodologies
available
to
achieve
C–C
bond
formation
via
photocatalytic
and
photo-electrocatalytic
direct
functionalization
of
simple
alkanes.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(6), P. 4156 - 4164
Published: March 7, 2024
Metal
impurities
can
complicate
the
identification
of
active
catalyst
species
in
transition
metal
catalysis
and
electrocatalysis,
potentially
leading
to
misleading
findings.
This
study
investigates
influence
on
photocatalysis.
Specifically,
photocatalytic
reaction
inert
alkanes
using
chlorides
without
use
an
external
photocatalyst
was
studied,
achieving
successful
C(sp
