Reviewing
photocatalytic
and
metal-catalyzed
disulfide
synthesis,
2021–2024,
emphasizes
efficiency,
selectivity,
sustainability
for
drug
material
science.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1683 - 1696
Published: Jan. 17, 2025
In
the
vanguard
of
sustainable
chemistry,
pursuit
efficient
pathways
for
synthesis
alkyl
bicyclo[1.1.1]pentane-heteroaryls
has
captured
attention
scientific
vanguard.
We
herein
report
a
groundbreaking
and
eco-conscious
multicomponent
coupling
reaction
that
paves
way
alkylation
heteroarylation
[1.1.1]propellane,
process
uniquely
enabled
by
photochemical
prowess
an
electron
donor–acceptor
(EDA)
complex.
This
method
is
distinguished
its
minimalist
yet
powerful
approach:
devoid
transition
metals,
additives,
photosensitizers.
Its
universality
further
exemplified
seamless
compatibility
broad
spectrum
halides
heteroarenes
under
standardized
conditions,
heralding
new
era
synthetic
versatility.
The
method's
practicality
underscored
capacity
late-stage
modification
pharmaceuticals,
offering
transformative
tool
enhancement
existing
drug
molecules.
Moreover,
facile
derivatization
synthesized
products
underscores
adaptability
potential
diverse
applications.
Our
mechanistic
studies
have
elucidated
underlying
radical-relay
pathway,
pinpointing
pivotal
role
EDA
complex
in
initiating
transformation.
discovery
not
only
enriches
our
fundamental
understanding
but
also
opens
avenues
strategic
optimization.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
In
this
study,
a
novel
approach
that
combines
photoinduced
electron
transfer
(ET)
with
hydrogen
atom
(HAT)
has
been
introduced
for
the
selective
β-C(sp3)–H
pyridination
of
carbonyl
compounds.
This
method
is
notable
its
absence
transition
metals
and
ability
to
function
under
benign
reaction
conditions,
resulting
in
range
pyridinated
derivatives
consistently
moderate
good
yields.
The
significance
technique
further
underscored
by
potential
late-stage
functionalization
pharmaceutically
significant
molecules.
Mechanistic
investigations
confirmed
proceeds
via
radical-mediated
pathway.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(33), P. 6650 - 6664
Published: Jan. 1, 2024
Titanium,
as
an
important
transition
metal,
has
garnered
extensive
attention
in
both
industry
and
academia
due
to
its
excellent
mechanical
properties,
corrosion
resistance,
unique
reactivity
organic
synthesis.
In
the
field
of
photocatalysis,
titanium-based
compounds
such
titanium
dioxide
(TiO
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(21), P. 4263 - 4273
Published: Aug. 28, 2024
Abstract
Aryl
radicals
are
important
intermediates
in
organic
synthesis.
The
generation
of
these
reactive
species
via
direct
decarboxylation
inexpensive
and
readily
available
aromatic
carboxylic
acids
is
an
attractive
goal.
However,
such
a
process
intrinsically
exhibits
high
energy
barriers
to
overcome,
which
consequence
usually
require
precious
metal
catalysis,
stoichiometric
oxidants
harsh
conditions,
suffering
from
limitations
as
poor
functional
group
tolerance
low
atom
economy.
In
recent
years,
photochemical
reactions
have
provided
new
approaches
address
this
challenge.
Three
major
strategies
been
introduced
emerging
field:
1)
one‐pot
in‐situ
activation
benzoic
generate
benzoyl
hypobromites
or
hypoiodites;
2)
the
use
specialized
photocatalysts
like
biphenyl/1,4‐dicyanobenzene
promote
through
photo‐induced
electron
transfer
charge
processes;
3)
LMCT
(Ligand‐to‐Metal
Charge
Transfer)
strategy
where
copper
iron
salts
coordinate
carboxylate
anion
upon
visible
light
excitation.
On
basis
three
strategies,
review
will
systematically
summarize
development
visible‐light‐induced
decarboxylative
functionalization
acids,
focusing
on
reaction
mechanism
substrate
scope,
discuss
their
prospects
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Exploring
new
synthetic
methods
that
harness
visible
light
represents
a
breakthrough
in
organic
synthesis.
Amides,
amines,
nitriles,
and
halides
are
essential
functional
groups
serve
as
key
building
blocks
the
synthesis
of
complex
molecules
medicinal
chemistry.
This
study
introduces
novel
intermolecular
benzylic
C–X
(C–N,
C–C,
C–Br)
bond
formation
via
photoredox
C(sp3)–H
bonds.
methodology
enables
secondary
amides,
through
reacting
substrates
with
readily
accessible
reagents
including
BocNH2,
benzamide,
acetamide,
TMSCN,
TBAB.
approach
displays
potential
being
sustainable
efficient
to
afford
amidation,
cyanation,
halogenation
products
good
yields.
Organic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
dual
catalysis
involving
both
anionic
and
cationic
species
of
an
ion-pairing
photocatalyst
is
achieved.
By
adopting
this
mode
action,
photocatalytic
hydrogen
transfer
cross-coupling
reactions
can
be
enabled
using
a
single
photocatalyst.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(15), P. 11370 - 11376
Published: Jan. 1, 2025
Herein,
we
have
developed
an
organophotocatalytic
trifluoromethylation
of
6-azauracils
using
inexpensive
Langlois
reagent
to
prepare
a
variety
trifluoromethylated
azauracil
derivatives
under
ambient
air
condition.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(19), P. 14691 - 14716
Published: Jan. 1, 2025
Transition
metal-free
benzylic
C(sp
3
)–H
activation
is
a
direct
strategy
for
forming
C–C
and
C–X
bonds.
This
review
highlights
C–H
activation/annulation
or
activation/functionalization
of
toluenes
using
non-metal
catalysts
promoters.
