Access to CF₃-benzofulvenes via palladium-catalyzed cascade arylation/Trost–Oppolzer cyclization/double-bond isomerization

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(26), P. 3551 - 3554

Published: Jan. 1, 2024

Highly stereoselective synthesis of CF 3 -benzofulvenes has been achieved through a Pd-catalyzed cascade reaction involving three consecutive transformations such as arylation, Trost–Oppolzer type Alder-ene reaction, and double bond isomerization.

Language: Английский

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Cross-conjugated vinylogous annulation of π-CF3-allyl Pd-complexes with 4-methyl-3-trifluoroacetyl-quinolones

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A hitherto unknown cross-conjugated vinylogous anionic annulation of π-CF 3 -allyl Pd-complexes with 4-methyl-3-trifluoroacetyl quinolones has been disclosed to access the diversely functionalized phenanthridones.

Language: Английский

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Synthesis of 3‐Aryl Oxindoles having Trifluoromethylated Quaternary Stereocenters via Catalyst Free Arylation

Advanced Synthesis & Catalysis, Journal Year: 2022, Volume and Issue: 365(1), P. 8 - 12

Published: Nov. 25, 2022

Abstract Herein we report the synthesis of 3‐aryl oxindoles having trifluoromethylated quaternary stereocenters through catalyst free arylation 3‐trifluoromethyl,3‐tosyloxy with anisoles. The transformation proceeds via electrophilic 3‐(trifluoromethyl)‐2 H ‐indolium intermediate (Michael acceptor), which is generated by heterolytic cleavage C‐OTs bond under metal‐free conditions in PEG‐400. developed strategy offers broad substrate scope, extending to N,N ‐dimethyl‐anilines, and thio‐anisole afford range 3‐trifluoromethyl,3‐aryl 62–91% yields. magnified image

Language: Английский

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Direct synthesis of trifluoroethylated benzofurans from silver-catalyzed annulation of trifluoromethyl propynols with phenols

Tetrahedron, Journal Year: 2022, Volume and Issue: 121, P. 132929 - 132929

Published: July 19, 2022

Language: Английский

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Expeditious synthesis of CF3-phenanthridones through a base mediated cross-conjugated vinylogous benzannulation (VBA)

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Herein, we report a mild, efficient, and rapid approach for the preparation of CF

Language: Английский

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A simple and efficient approach for the synthesis of functionalized naphtho[2,1-b]furan via an one-pot, three-component reaction between Meldrum's acid, arylglyoxals, and β-naphthol

ARKIVOC, Journal Year: 2022, Volume and Issue: 2022(9), P. 90 - 99

Published: Oct. 25, 2022

A simple and efficient method for the synthesis of 2-(2-(aryl)naphtho[2,1-b]furan-1-yl)acetic acid derivatives via an one-pot three-component reaction Meldrum's acid, arylglyoxals, β-naphthol in presence triethylamine (Et3N) is reported.The protocol avoids use expensive catalysts, chromatographic separation provides a wide range novel naphtho[2,1-b]furans excellent yields.Spectral data elemental analysis have characterized newly synthesized compounds.

Language: Английский

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Five-membered ring systems: furans and benzofurans

Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 209 - 253

Published: Jan. 1, 2023

Language: Английский

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A first example of a palladium-catalyzed allylic substitution reaction at a perfluoroalkylene-attached asymmetric carbon center with carbon, nitrogen, and oxygen nucleophiles

Journal of Fluorine Chemistry, Journal Year: 2023, Volume and Issue: 273, P. 110234 - 110234

Published: Dec. 2, 2023

Language: Английский

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